Publication

Rate enhancing and rate retarding effects of methoxy substituents on arene metalation

Manfred Schlosser
1999
Journal Articles

Abstract

Competition expts. have been performed to det. the rates, relative to benzene, with which anisole, the three dimethoxybenzenes and the three trimethoxybenzenes are deprotonated by sec-butyllithium. Only the first substituent (anisole relative to benzene) has a strong effect (krelf 2800); the second one accelerates moderately at best (1,3-dimethoxybenzene relative to anisole: krelf 12). Methoxy groups being located para with respect to the metalation site or occupying a vicinal position to another methoxy substituent diminish the reactivity by up to two powers of ten (relative to anisole). These surprising findings are without precedence. [on SciFinder (R)]

Official source

https://infoscience.epfl.ch/entities/publication/1b3025ac-88a2-467e-a1d2-689a1eddcdb9

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Manfred Schlosser
1999
Journal Articles

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/1b3025ac-88a2-467e-a1d2-689a1eddcdb9

About this result

Related concepts (25)

Substituent

In organic chemistry, a substituent is one or a group of atoms that replaces (one or more) atoms, thereby becoming a moiety in the resultant (new) molecule. (in organic chemistry and biochemistry, the terms substituent and functional group, as well as side chain and pendant group, are used almost interchangeably to describe those branches from the parent structure, though certain distinctions are made in polymer chemistry. In polymers, side chains extend from the backbone structure.

Benzene

Benzene is an organic chemical compound with the molecular formula C6H6. The benzene molecule is composed of six carbon atoms joined in a planar ring with one hydrogen atom attached to each. Because it contains only carbon and hydrogen atoms, benzene is classed as a hydrocarbon. Benzene is a natural constituent of petroleum and is one of the elementary petrochemicals. Due to the cyclic continuous pi bonds between the carbon atoms, benzene is classed as an aromatic hydrocarbon.

Metal–halogen exchange

In organometallic chemistry, metal–halogen exchange is a fundamental reaction that converts an organic halide into an organometallic product. The reaction commonly involves the use of electropositive metals (Li, Na, Mg) and organochlorides, bromides, and iodides. Particularly well-developed is the use of metal–halogen exchange for the preparation of organolithium compounds. Two kinds of lithium–halogen exchange can be considered: reactions involving organolithium compounds and reactions involving lithium metal.