Coral holobiont cues prime Endozoicomonas for a symbiotic lifestyle

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Approximately eight billion people are living on Earth today with more than half (55%, similar to 4.2 billion) living in cities-a proportion predicted to increase to 70% (similar to 6.6. billion) by 2050. As the human population grows, urban residents will ...

Mountain regions face a variety of natural hazards that menace infrastructure and the people living in these areas. Human activity in these areas is intensifying, making hazard analysis and risk mitigation critical. Switzerland, with its densely populated ...

Fossil coral skeletons that retain their original aragonitic mineralogy are generally considered diagenetically unaltered and reliable paleoenvironmental archives. We investigated whether oxygen isotope exchange can occur between these skeletons and ambien ...

While largely neglected over decades during which adaptive immunity captured most of the attention, innate immune mechanisms have now become central to our understanding of immunology. Innate immunity provides the first barrier to infection in vertebrates, ...

Infectious agents contribute significantly to the global burden of diseases through both acute infection and their chronic sequelae. We leveraged the UK Biobank to identify genetic loci that influence humoral immune response to multiple infections. From 45 ...

Over the past two decades, protein S-acylation (often referred to as S-palmitoylation) has emerged as an important regulator of vital signalling pathways. S-Acylation is a reversible post-translational modification that involves the attachment of a fatty a ...

Objectives The endosymbiosis with Symbiodiniaceae is key to the ecological success of reef-building corals. However, climate change is threatening to destabilize this symbiosis on a global scale. Most studies looking into the response of corals to heat str ...

The advent of immunotherapy, such as immune checkpoint blockade (ICB) and adoptive transfer of cytotoxic lymphocytes, has transformed the clinical care of cancer. However, a significant proportion of patients are resistant to immunotherapy or experience re ...

Heterochromatin loss and genetic instability enhance cancer progression by favoring clonal diversity, yet uncontrolled replicative stress leads to mitotic catastrophe and inflammatory responses that promote immune rejection. KRAB domain-containing zinc fin ...

Global climate warming is leading to more frequent and severe extreme weather events, with alpine regions like the European Alps being particularly vulnerable. This thesis explores future changes in extreme weather dynamics in the southeastern Swiss Alps a ...

Traditional cell cultures have long been fundamental to biological research, offering an alternative to animal models burdened by ethical constraints and procedural intricacies, often lacking relevance to human physiology and disease. Moreover, their inabi ...

Mycobacterium Tuberculosis is a highly effective pathogen infecting nearly a third of the world's population. An M. tuberculosis infection starts when droplets containing bacteria enter an individual's lungs. The first host cells to contact the bacteria ar ...

Reduction in snow cover, depth, onset, and duration of seasonal snow in mid-latitude regions due to climate warming has multiple global and local scale ecosystem impacts. These effects include modulations of the hydrological cycles and increases in land su ...

Smart meters, devices measuring the electricity and gas consumption of a household, are currently being deployed at a fast rate throughout the world. The data they collect are extremely useful, including in the fight against climate change. However, these ...

The oxygen isotope compositions of fossil biocalcites, such as foraminifera, bivalves, brachiopods, and belemnites have allowed for reconstructions of sea surface and deep ocean temperatures throughout the Phanerozoic and constitute the most important reco ...

The West African region, one of the largest urban agglomerations in Africa has over decades experienced rapid rate of urbanization. The urbanization processes have been associated with manifold environmental and socioeconomic challenges including inefficie ...

Inflammation stands as a dynamic and intricate biological process, promoting vital defence mechanisms against harmful stimuli, including infections and injuries, to drive pathogen clearance and healing. On one hand, these responses can manifest acutely and ...

Background Excessive inflammation, hemolysis, and accumulation of labile heme play an essential role in the pathophysiology of multi-organ dysfunction syndrome (MODS) in sepsis. Alpha1-antitrypsin (AAT), an acute phase protein with heme binding capacity, i ...

The elderly population is highly susceptible to developing respiratory diseases, including tuberculosis, a devastating disease caused by the airborne pathogen Mycobacterium tuberculosis ( M.tb ) that kills one person every 18 seconds. Once M.tb reaches the ...

Glacier-fed streams are the cold, ultra-oligotrophic, and unstable streams that are fed by glacial meltwater. Despite these extreme conditions, they harbour a diverse and abundant microbial diversity that develops into biofilms, covering the boulders and s ...

Coral holobiont cues prime Endozoicomonas for a symbiotic lifestyle

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Urban heat in global cities and the role of nature-based solutions in mitigating future climate risks

Granular Avalanche Impact on a Structure using DEM and FEM

Rapid isotopic exchange in mineralogically unaltered coral skeletons

The conceptual foundations of innate immunity: Taking stock 30 years later

A common NFKB1 variant detected through antibody analysis in UK Biobank predicts risk of infection and allergy

Mechanisms and functions of protein S-acylation

Gene expression of Pocillopora damicornis coral larvae in response to acidification and ocean warming

Exploration and modulation of mechanical cues for enhanced cancer immunotherapy

A Cluster of Evolutionarily Recent KRAB Zinc Finger Proteins Protects Cancer Cells from Replicative Stress–Induced Inflammation

Future Changes in Dynamics of Extreme Precipitation and Dry Periods in the Swiss Alps and Consequences for Hydropower Production

Accessible and highly observable gastrointestinal organoid model systems for studying host-pathogen interactions

Single-cell analysis of the interactions between Mycobacterium tuberculosis and macrophages

Effects of reduced snowpack due to climate warming on abiotic and biotic soil properties in alpine and boreal forest systems

Re-pseudonymization Strategies for Smart Meter Data Are Not Robust to Deep Learning Profiling Attacks

Diagenetic isotope exchange in biocalcites for paleoclimate reconstruction

Modelling the dynamics of urbanization for urban sustainability in West Africa

Exploring the role of cGAS-STING-mediated inflammation in age-associated neurodegeneration and antitumor immunity

Alpha1-antitrypsin improves survival in murine abdominal sepsis model by decreasing inflammation and sequestration of free heme

Human alveolar lining fl uid from the elderly promotes Mycobacterium tuberculosis intracellular growth and translocation into the cytosol of alveolar epithelial cells

The microbial genomics of glacier-fed streams: adaptations to an extreme ecosystem