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Engineering Stem Cell Self-organization to Build Better Organoids

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OASIS: Optimisation-based Activity Scheduling with Integrated Simultaneous choice dimensions

Michel Bierlaire, Timothy Michael Hillel, Janody Pougala

Activity-based models offer the potential of a far deeper understanding of daily mobility behaviour than trip-based models. However, activity-based models used both in research and practice have often relied on applying sequential choice models between sub ...

2023

Cross-anatomical single-cell definition and characterization of human adipose progenitor niche

Radiana Ferrero

Adipose tissue is a key metabolic and highly-dynamic organ whose dysregulation may cause clinical conditions of concern such as obesity and lipodystrophy. Its function varies based on the anatomy, in fact, visceral adipose tissue expansion carries a greate ...

EPFL2023

Comparative Evaluation of Lipofectamine and Dendrimer for Transfection of Short RNA Into Human T47D and MCF-10A Cell Lines

Erfan Shirzadi

Purpose: Non-viral transfection approaches are extensively used in cancer therapy. The future of cancer therapy lies on targeted and efficient drug/gene delivery. The aim of this study was to determine the transfection yields of two commercially available ...

2023

Compassion and Engineering Students’ Moral Reasoning: The Emotional Experience of Engineering Ethics Cases

Roland John Tormey, Nihat Kotluk

Background: There has been an increase in interest in emotion in engineering and science ethics education. There is also evidence that emotional content in case studies may improve students’ learning and enhance awareness, understanding, and motivation con ...

American Society for Engineering Education2023

Educating Engineering Students to Address Bias and Discrimination Within Their Project Teams

Roland John Tormey, Siara Ruth Isaac, Nihat Kotluk

What training should engineering students receive to enable them to contribute to reducing bias, discrimination and the persistent lack of diversity in engineering? Collaboration is central to professional engineering work and, consequently, teamwork and g ...

2023

Emotional labor experienced in team-projects: A comparison of engineering and hospitality students

Roland John Tormey, Nihat Kotluk

Team projects are an integral part of the student learning experience. However, emotions can significantly affect student performance during team projects. Students use different emotion regulation strategies, such as surface-acting (emotive dissonance) an ...

2023

Engineered substrates incapable of induction of chondrogenic differentiation compared to the chondrocyte imprinted substrates

Philippe Renaud, Leila Montazeri

It is well established that surface topography can affect cell functions. However, finding a reproducible and reliable method for regulating stem cell behavior is still under investigation. It has been shown that cell imprinted substrates contain micro- an ...

IOP Publishing Ltd2023

Self-sustained dynamics and forced resonant oscillations in flows: cross-junction jets and sloshing liquids

Alessandro Bongarzone

In engineering, oscillatory instabilities and resonances are often considered undesirable flow features and measures are taken to avoid them. This may include avoiding certain parametric regions or implementing control and mitigation strategies. However, t ...

EPFL2023

A single-cell-based characterization of mammalian adipose stem and progenitor cell heterogeneity and function

Pernille Yde Rainer

White adipose tissue (WAT) is a cellularly heterogeneous endocrine organ that not only serves as a reservoir for storing and releasing energy but also actively participates in metabolic homeostasis. Given the current rise in obesity and its associated como ...

EPFL2023

Development of a Robotic Microsurgeon for Embryonic Research

Ece Özelçi

Understanding how biological matter takes its shape is instrumental to biology, bioengineering, medicine, and bioinspired engineering. Gaining information on the principles of morphogenesis could enable clinicians to correct developmental abnormalities, ev ...

EPFL2023

Making Bridges Sustainable

Eugen Brühwiler

Lack of incentives mainly explains why the implementation of novel methods and technologies in bridge engineering practice is generally postponed by the engineering community despite the urgent need to advance also bridge engineering to meet the objectives ...

Taylor and Francis / CRC Press2023

Multimodal characterization of murine gastruloid development

Matthias Lütolf, Alexandre Gauthier Aurèle Mayran, Stefano Davide Vianello, Raphaël Ortiz

Gastruloids are 3D structures generated from pluripotent stem cells recapitulating fundamental principles of embryonic pattern formation. Using single-cell genomic analysis, we provide a resource mapping cell states and types during gastruloid development ...

CELL PRESS2023

Disruption of stem cell niche-confined R-spondin 3 expression leads to impaired hematopoiesis

Freddy Radtke, Ute Koch

Self-renewal and differentiation of stem and progenitor cells are tightly regulated to ensure tissue homeostasis. This regulation is enabled both remotely by systemic circulating cues, such as cytokines and hormones, and locally by various niche-confined f ...

ELSEVIER2023

Biochemistry of Aminoacyl tRNA Synthetase and tRNAs and Their Engineering for Cell-Free and Synthetic Cell Applications

Sebastian Maerkl, Ragunathan Bava Ganesh

Cell-free biology is increasingly utilized for engineering biological systems, incorporating novel functionality, and circumventing many of the complications associated with cells. The central dogma describes the information flow in biology consisting of t ...

FRONTIERS MEDIA SA2022

Engineering Agrobacterium tumefaciens Adhesion to Target Cells

Alix Kim Lan Pham, Alexandre Louis André Persat, Xavier Jean-Yves Pierrat, Zaïnebe Dhirani, Jeremy Pak Hei Wong

Agrobacterium tumefaciens is a plant pathogen commonly repurposed for genetic modification of crops. Despite its versatility, it remains inefficient at transferring DNA to many hosts, including to animal cells. Like many pathogens, physical contact between ...

AMER CHEMICAL SOC2022

Deciphering the molecular events leading to the global restoration of the chromatin landscape during mitotic exit

Silja Michelle Placzek

Two fundamental properties of embryonic stem cells (ESCs) are their ability to self-renew and differentiate into all somatic cell types. Maintenance of their identity faces major challenges when transitioning through mitosis, as most DNA-binding proteins a ...

EPFL2023

Engineering of Existing Structures: The Need and Place for Non-destructive Evaluation

Guillaume Justin Henriques, Eugen Brühwiler, Numa Joy Bertola, Thomas Schumacher

Structural engineers today are still educated mainly to design new structures. This ignores the fact that structures already exist and need to be maintained. Students are thus often ill-equipped to deal with maintenance and preservation of existing structu ...

2022

Engineering Materials for Neurotechnology

Diego Ghezzi

Neurotechnology applies methods and devices to mitigate the burden of neurological and mental disorders. In particular, neural interfaces establish a long-term, seamless, symbiotic integration between implants and neural tissue. Materials play a pivotal ro ...

WILEY-V C H VERLAG GMBH2023