Engineering Stem Cell Self-organization to Build Better Organoids

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Activity-based models offer the potential of a far deeper understanding of daily mobility behaviour than trip-based models. However, activity-based models used both in research and practice have often relied on applying sequential choice models between sub ...

Adipose tissue is a key metabolic and highly-dynamic organ whose dysregulation may cause clinical conditions of concern such as obesity and lipodystrophy. Its function varies based on the anatomy, in fact, visceral adipose tissue expansion carries a greate ...

Purpose: Non-viral transfection approaches are extensively used in cancer therapy. The future of cancer therapy lies on targeted and efficient drug/gene delivery. The aim of this study was to determine the transfection yields of two commercially available ...

Background: There has been an increase in interest in emotion in engineering and science ethics education. There is also evidence that emotional content in case studies may improve students’ learning and enhance awareness, understanding, and motivation con ...

What training should engineering students receive to enable them to contribute to reducing bias, discrimination and the persistent lack of diversity in engineering? Collaboration is central to professional engineering work and, consequently, teamwork and g ...

Team projects are an integral part of the student learning experience. However, emotions can significantly affect student performance during team projects. Students use different emotion regulation strategies, such as surface-acting (emotive dissonance) an ...

It is well established that surface topography can affect cell functions. However, finding a reproducible and reliable method for regulating stem cell behavior is still under investigation. It has been shown that cell imprinted substrates contain micro- an ...

In engineering, oscillatory instabilities and resonances are often considered undesirable flow features and measures are taken to avoid them. This may include avoiding certain parametric regions or implementing control and mitigation strategies. However, t ...

White adipose tissue (WAT) is a cellularly heterogeneous endocrine organ that not only serves as a reservoir for storing and releasing energy but also actively participates in metabolic homeostasis. Given the current rise in obesity and its associated como ...

Understanding how biological matter takes its shape is instrumental to biology, bioengineering, medicine, and bioinspired engineering. Gaining information on the principles of morphogenesis could enable clinicians to correct developmental abnormalities, ev ...

Lack of incentives mainly explains why the implementation of novel methods and technologies in bridge engineering practice is generally postponed by the engineering community despite the urgent need to advance also bridge engineering to meet the objectives ...

Gastruloids are 3D structures generated from pluripotent stem cells recapitulating fundamental principles of embryonic pattern formation. Using single-cell genomic analysis, we provide a resource mapping cell states and types during gastruloid development ...

Self-renewal and differentiation of stem and progenitor cells are tightly regulated to ensure tissue homeostasis. This regulation is enabled both remotely by systemic circulating cues, such as cytokines and hormones, and locally by various niche-confined f ...

Cell-free biology is increasingly utilized for engineering biological systems, incorporating novel functionality, and circumventing many of the complications associated with cells. The central dogma describes the information flow in biology consisting of t ...

Agrobacterium tumefaciens is a plant pathogen commonly repurposed for genetic modification of crops. Despite its versatility, it remains inefficient at transferring DNA to many hosts, including to animal cells. Like many pathogens, physical contact between ...

Two fundamental properties of embryonic stem cells (ESCs) are their ability to self-renew and differentiate into all somatic cell types. Maintenance of their identity faces major challenges when transitioning through mitosis, as most DNA-binding proteins a ...

Structural engineers today are still educated mainly to design new structures. This ignores the fact that structures already exist and need to be maintained. Students are thus often ill-equipped to deal with maintenance and preservation of existing structu ...

Neurotechnology applies methods and devices to mitigate the burden of neurological and mental disorders. In particular, neural interfaces establish a long-term, seamless, symbiotic integration between implants and neural tissue. Materials play a pivotal ro ...

Engineering Stem Cell Self-organization to Build Better Organoids

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OASIS: Optimisation-based Activity Scheduling with Integrated Simultaneous choice dimensions

Cross-anatomical single-cell definition and characterization of human adipose progenitor niche

Comparative Evaluation of Lipofectamine and Dendrimer for Transfection of Short RNA Into Human T47D and MCF-10A Cell Lines

Compassion and Engineering Students’ Moral Reasoning: The Emotional Experience of Engineering Ethics Cases

Educating Engineering Students to Address Bias and Discrimination Within Their Project Teams

Emotional labor experienced in team-projects: A comparison of engineering and hospitality students

Engineered substrates incapable of induction of chondrogenic differentiation compared to the chondrocyte imprinted substrates

Self-sustained dynamics and forced resonant oscillations in flows: cross-junction jets and sloshing liquids

A single-cell-based characterization of mammalian adipose stem and progenitor cell heterogeneity and function

Development of a Robotic Microsurgeon for Embryonic Research

Making Bridges Sustainable

Multimodal characterization of murine gastruloid development

Disruption of stem cell niche-confined R-spondin 3 expression leads to impaired hematopoiesis

Biochemistry of Aminoacyl tRNA Synthetase and tRNAs and Their Engineering for Cell-Free and Synthetic Cell Applications

Engineering Agrobacterium tumefaciens Adhesion to Target Cells

Deciphering the molecular events leading to the global restoration of the chromatin landscape during mitotic exit

Engineering of Existing Structures: The Need and Place for Non-destructive Evaluation

Engineering Materials for Neurotechnology