Publication

Additive manufacturing of novel tubular designs using a filament-driven opensource melt electrowriting machine

Arnaud Bertsch
2024

Abstract

Over the last two decades, additive manufacturing has been gaining significant attention in tissue engineering and biofabrication research as a versatile class of manufacturing technologies. For biomedical research, high resolution 3D printing techniques, such as melt electrowriting (MEW) are of interest due to their exceptional ability to replicate fine features and complex microarchitecture of native tissues to mimic both their structure and function. 1 Most MEW happens on either flat or tubular collectors, the latter being often used to mimic blood vessels or as potential nerve guides. 2 To date, tubular scaffolds are fully closed, while we have developed a novel scaffold design which is partially opened allowing for potential application as nerve guide after patterning of gold on the inside.

Official source

https://infoscience.epfl.ch/entities/publication/07eb67fd-3095-4858-8dd2-6a6be2ce5329

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Arnaud Bertsch
2024

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/07eb67fd-3095-4858-8dd2-6a6be2ce5329

About this result

Related concepts (25)

Tissue engineering

Tissue engineering is a biomedical engineering discipline that uses a combination of cells, engineering, materials methods, and suitable biochemical and physicochemical factors to restore, maintain, improve, or replace different types of biological tissues. Tissue engineering often involves the use of cells placed on tissue scaffolds in the formation of new viable tissue for a medical purpose but is not limited to applications involving cells and tissue scaffolds.

Nerve injury

Nerve injury is an injury to nervous tissue. There is no single classification system that can describe all the many variations of nerve injuries. In 1941, Seddon introduced a classification of nerve injuries based on three main types of nerve fiber injury and whether there is continuity of the nerve. Usually, however, peripheral nerve injuries are classified in five stages, based on the extent of damage to both the nerve and the surrounding connective tissue, since supporting glial cells may be involved.

Nerve guidance conduit

A nerve guidance conduit (also referred to as an artificial nerve conduit or artificial nerve graft, as opposed to an autograft) is an artificial means of guiding axonal regrowth to facilitate nerve regeneration and is one of several clinical treatments for nerve injuries. When direct suturing of the two stumps of a severed nerve cannot be accomplished without tension, the standard clinical treatment for peripheral nerve injuries is autologous nerve grafting.

Related publications (2)

Additive manufacturing of novel tubular designs using a filament-driven opensource melt electrowriting machine

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