Automatic Tracking of Individual Fluorescence Particles: Application to the Study of Chromosome Dynamics

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Centromere structure and function: lessons from Drosophila

Eftychia Kyriacou

The fruit fly Drosophila melanogaster serves as a powerful model organism for advancing our understanding of biological processes, not just by studying its similarities with other organisms including ourselves but also by investigating its differences to u ...

Genetics Society America2023

Dynamics of CLIMP-63 S-acylation control ER morphology

Vassily Hatzimanikatis, Françoise Gisou van der Goot Grunberg, Graham Knott, Kathryn Hess Bellwald, Luciano Andres Abriata, Laurence Gouzi Abrami, Patrick Alain Sandoz, Catherine Maclachlan, Béatrice Kunz, Sylvia Ho, Gard Spreemann, Robin Alexander Denhardt-Eriksson

A key player in the formation of endoplasmic reticulum sheets is CLIMP-63, but mechanistic details remained elusive. Here authors combined cellular experiments and mathematical modelling to show that S-acylation of CLIMP-63 regulates its function by mediat ...

Nature Portfolio2023

WarpAttack: Bypassing CFI through Compiler-Introduced Double-Fetches

Mathias Josef Payer, Flavio Toffalini, Luca Di Bartolomeo

Code-reuse attacks are dangerous threats that attracted the attention of the security community for years. These attacks aim at corrupting important control-flow transfers for taking control of a process without injecting code. Nowadays, the combinations o ...

IEEE COMPUTER SOC2023

Multivalent Peptide Ligands To Probe the Chromocenter Microenvironment in Living Cells

Beat Fierz, Pablo Rivera Fuentes, Nora Guidotti, Maxime Nicolas Mivelaz, Adam Miklos Eördögh

Chromatin is spatially organized into functional states that are defined by both the presence of specific histone post-translational modifications (PTMs) and a defined set of chromatin-associated “reader” proteins. Different models for the underlying mecha ...

2022

Simulating time-varying strong lenses

Georgios Vernardos

We present a self-consistent and versatile forward modelling software package that can produce time series and pixel-level simulations of time-varying strongly lensed systems. The time dimension, which needs to take into account different physical mechanis ...

OXFORD UNIV PRESS2022

Hardware and Software Support for RPC-Centric Server Architecture

Mark Johnathon Sutherland

Online services have become ubiquitous in technological society, the global demand for which has driven enterprises to construct gigantic datacenters that run their software. Such facilities have also recently become a substrate for third-party organizatio ...

EPFL2022

Automated Verification of Network Function Binaries

George Candea, Aikaterini Argyraki, Solal Vincenzo Pirelli

Formally verifying the correctness of software network functions (NFs) is necessary for network reliability, yet existing techniques require full source code and mandate the use of specific data structures. We describe an automated technique to verify NF b ...

USENIX Association2022

Stain-free identification of cell nuclei using tomographic phase microscopy in flow cytometry

Demetri Psaltis, Joowon Lim

The accurate identification of the three-dimensional quantitative shape of a cell nucleus is now possible without fluorescent staining by applying computational segmentation to refractive index tomograms recorded in the flow cytometry mode. ...

Nature Publishing Group2022

Metabolic regulation of cytokinesis in Schizosaccharomyces pombe

Özge Uysal Özdemir

All cells need to be able to sense their environment, and adapt their metabolism, growth and cell division appropriately. In this study, I examined the response of Schizosaccharomyces pombe to a change in the carbon source and how that affects cytokinesis. ...

EPFL2022