RING1 proteins contribute to early proximal-distal specification of the forelimb bud by restricting Meis2 expression

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Here the authors show that a strong enhancer sequence can be controlled by the chromatin environment provided by a topologically associated domain (TAD) located nearby. An enhancer relocated by homologous recombination takes all the hallmarks of its new ne ...

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Hox genes encode transcription factors (TFs) that establish morphological diversity in the developing embryo. The similar DNA-binding motifs of the various HOX TFs contrast with the wide-range of HOX-dependent genetic programs. The influence of the chromat ...

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RING1 proteins contribute to early proximal-distal specification of the forelimb bud by restricting Meis2 expression

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In vitro endoderm emergence and self-organisation in the absence of extraembryonic tissues and embryonic architecture

Context-dependent enhancer function revealed by targeted inter-TAD relocation

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In vitro modeling of early mouse development

Chromatin topology and the timing of enhancer function at the HoxD locus

HOX13-dependent chromatin accessibility underlies the transition towards the digit development program

Control of Hox transcription factor concentration and cell-to-cell variability by an auto-regulatory switch

Coordinated Hoxd genes expression during embryogenesis is dependent on a strict disposition of genes and polarized regulators within the HoxD cluster

Heterogeneous combinatorial expression of Hoxd genes in single cells during limb development

Multi-axial self-organization properties of mouse embryonic stem cells into gastruloids

Probing the distribution of cortical components, including PtdIns(4,5)P2, during asymmetric division of C. elegans embryos

Integration of Shh and Fgf signaling in controlling Hox gene expression in cultured limb cells

The HoxD cluster is a dynamic and resilient TAD boundary controlling the segregation of antagonistic regulatory landscapes

From the early steps of whisker formation to its evolutionary disappearance: the (curious) case of Prdm1 and its regulation

Regulatory Switches Underlie Hoxd Gene Activation in Tetrapod Limbs

Anthrax toxin receptor 2a controls mitotic spindle positioning

A switch between topological domains underlies HoxD genes collinearity in mouse limbs

Asymmetric Cell Division in the Skin

The microenvironment patterns the pluripotent mouse epiblast through paracrine Furin and Pace4 proteolytic activities