Publications related to Proliferation-driven mechanical compression induces signalling centre formation during mammalian organ development

Related publications (28)

Cyclic loading of WC-Ni by FEM with a realistic 3D morphology

Daniele Mari, Lucas Eric Jacques Degeneve

A Finite Element Model produced from a real WC-10wt.%Co sample is used to study the mechanical behavior of cemented carbides in compression tests. The model is obtained by slicing the sample by Focused Ion Beam and reconstructing it. This model is used to ...

2025

The Influence of Micro- and Macrocracks on the Permeability of Granite

Marie Estelle Solange Violay

Damage zones exist around crustal faults, where micro- and macrocracks coexist and form a complex conduit network for fluid flow. The permeability of these zones can change rapidly as the crack network evolves during deformation. To investigate the relativ ...

SPRINGER WIEN2024

Strain engineering and strain measurement by spring tethers on suspended epitaxial GaN-on-Si photonic crystal devices

Romuald Houdré, Jun Wang

Suspended epitaxial gallium nitride (GaN) on silicon (Si) photonic crystal devices suffer from large residual tensile strain, especially for long waveguides, because fine structures tend to crack due to large stress. By introducing spring-like tethers, des ...

Iop Publishing Ltd2024

A novel fatigue life prediction methodology based on energy dissipation in viscoelastic materials, synergistic effects of stress level, stress ratio, and temperature

Thomas Keller, Lulu Liu, Abdolvahid Movahedirad

This work introduces a new methodology to predict the fatigue life of viscoelastic materials by considering the creep effect on fatigue behavior under the concurrent effects of stress level, stress ratio, and temperature. The model established based on the ...

2024

Frictional weakening leads to unconventional singularities during dynamic rupture propagation

Marie Estelle Solange Violay, François Xavier Thibault Passelègue, Mathias Alexandre David Lebihain, Federica Paglialunga

Earthquakes i.e. frictional ruptures, are commonly described by singular solutions of shear crack motions. These solutions assume a square root singularity order around the rupture tip and a constant shear stress value behind it, implying scale-independent ...

2024

Dataset for "Complexity of crack front geometry enhances toughness of brittle solids"

John Martin Kolinski, Chenzhuo Li, Xinyue Wei

This data package supports the publication 'Complexity of crack front geometry enhances toughness of brittle solids' by Xinyue Wei, Chenzhuo Li, Cían McCarthy, and John M. Kolinski Nature physics (2024) - https://doi.org/10.1038/s41567-024-02435-x DOI: 1 ...

Zenodo2024

Water weakening and the compressive brittle strength of carbonates: Influence of fracture toughness and static friction

Marie Estelle Solange Violay, Corentin Jean-Marie Rémi Noël, Barnaby Padraig Fryer

Water is ubiquitous within the pore space of rocks and has been shown to affect their physical and mechanical behaviour. Indeed, water can act on the rock strength via mechanical (i.e., reducing the effective stresses) or chemical effects (e.g., mineral di ...

2024

Influence of model uncertainty and long term deformations in action effects calculation in reinforced concrete structures

Xhemsi Malja

Most codes of practice adopt a semi probabilistic design approach for the dimensioning and assessment of structures. Accordingly, structural safety is ensured by performing limit state verifications using design values determined with adequately calibrated ...

EPFL2024

Characterization of the gut-bone marrow axis through bile acid signaling

Alejandro Alonso Calleja

Communication between the intestine and other organs such as the lungs, brain or bones is mediated by several metabolites, like short-chain fatty acids or bile acids, that relay information about nutritional and microbiota status. Bile acids are endogenous ...

EPFL2024

Computational fluid-structure interaction analysis of the end-to-side radio-cephalic arteriovenous fistula

Alfio Quarteroni, Fabio Marcinno

Background and Objective: In the current work, we present a descriptive fluid-structure interaction computational study of the end -to -side radio-cephalic arteriovenous fistula. This allows us to account for the different thicknesses and elastic propertie ...

Elsevier Ireland Ltd2024

Androgen Receptor Signaling in in vivo models of Estrogen Receptor-positive Breast Cancer and Normal Breast Epithelium

Andrea Agnoletto

Steroid hormone receptors (HRs) are ligand-activated transcription factors that play a pivotal role in breast development and carcinogenesis. It is well established that estrogen receptor (ER) signaling is a major proliferative driver in estrogen receptor ...

EPFL2024

Accessible and highly observable gastrointestinal organoid model systems for studying host-pathogen interactions

Moritz Hofer

Traditional cell cultures have long been fundamental to biological research, offering an alternative to animal models burdened by ethical constraints and procedural intricacies, often lacking relevance to human physiology and disease. Moreover, their inabi ...

EPFL2024

A single-cell-based characterization of mammalian adipose stem and progenitor cell heterogeneity and function

Pernille Yde Rainer

White adipose tissue (WAT) is a cellularly heterogeneous endocrine organ that not only serves as a reservoir for storing and releasing energy but also actively participates in metabolic homeostasis. Given the current rise in obesity and its associated como ...

EPFL2023

Simple shear extrusion versus equal channel angular pressing: A comparative study on the microstructure and mechanical properties of an Mg alloy

Roland Logé, Cyril Cayron, Aryan Rezaei Rad

Two severe plastic deformation (SPD) techniques of simple shear extrusion (SSE) and equal channel angular pressing (ECAP) were employed to process an extruded Mg -6Gd -3Y -1.5Ag (wt%) alloy at 553 K for 1, 2, 4 and 6 passes. The microstructural evolutions ...

KEAI PUBLISHING LTD2023

Drained Clay-Pipe Interface Resistance at Low Normal Stresses and Elevated Temperatures

Roba Houhou

Offshore pipelines that transport hydrocarbons under high pressure and high temperature are usually thermally insulated to maintain an elevated temperature and prevent any heat loss to the surroundings. However, the temperatures at the outer-wall of the pi ...

AMER SOC CIVIL ENGINEERS2023

Nanomechanical Modeling of the Bending Response of Silicon Nanowires

Yusuf Leblebici, Zuhal Tasdemir

Understanding the mechanical behavior of silicon nanowiresis essentialfor the implementation of advanced nanoscale devices. Although bendingtests are predominantly used for this purpose, their findings shouldbe properly interpreted through modeling. Variou ...

AMER CHEMICAL SOC2023

Shear strength and shear stiffness analysis of compacted Wyoming-type bentonite

Alessio Ferrari

Wyoming-type bentonite is one of the materials to be used as part of the Engineered Barrier System (EBS) in deep geological disposal facilities for the safe disposal of spent nuclear fuel.In the KBS-3 type repository, the canisters containing the spent fue ...

ELSEVIER2023

Proposed residual stress model for hot‐rolled wide flange steel cross sections

Dimitrios Lignos, Albano António De Abreu E Presa De Castro E Sousa, Andronikos Skiadopoulos

Residual stresses in hot-rolled wide flange steel cross sections may lead to premature yielding, accelerated corrosion and brittle fracture of steel members. The above phenomena lead to a loss of a steel member's stiffness and resistance under mechanical l ...

Ernst & Sohn2023

Elastic limit tensile stress of UHPFRC: Method of determination and effect of fiber orientation

Eugen Brühwiler, Emmanuel Denarié, Jian Zhan

This paper discusses the influence of fiber orientation on elastic limit tensile stress of ultra-high performance fiber reinforced cementitious composites (UHPFRC). An original model relating elastic limit tensile stress to fiber orientation is proposed, a ...

2023

Experimental investigation of rotational behavior of pseudo-ductile adhesive angle joints exhibiting variable strain rate

Thomas Keller, Ghazaleh Eslami, Abdolvahid Movahedirad

Pseudo-ductile behavior in composite structural frames can be achieved by enabling their beam-column joints to exhibit nonlinear structural response due to progressive damage, by using pseudo-ductile adhesives. This study investigates the static behavior o ...

2023