Inner ear cellular imaging through scattering bone

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Three-dimensional fabrication of sub-micron optical waveguides in PDMS and other polymer materials

Optical waveguides are one of the most important photonic components. They are indispensable tools in many of todayâ s technologies because of their capacity of guiding light. In particular, compact, low loss, flexible polymer optical waveguides are cruci ...

EPFL2021

Contactless Optical Packaging Concept for Laser to Fiber Coupling

Yves Bellouard, Saood Ibni Nazir

A novel method for the laser to fiber coupling is presented in which coarse alignment is achieved through micromachined v-grooves and mirrors in a fused silica substrate. Furthermore, fine repositioning is done in a noncontact manner by using a femtosecond ...

2021

A tunable femtosecond fiber laser source for multiphoton emission microscopy

Pierre-Marc Jean Marie Dansette

Second harmonic generation microscopy is used to image interfaces or non-centrosymmetric structures and molecules. Two-photon fluorescence microscopy can image molecules within cells without using markers. Thus those technics have lead to advances in our u ...

EPFL2021

Efficient viral transduction in mouse inner ear hair cells with utricle injection and AAV9-PHP.B

Bernard Schneider, Paola Andrea Solanes Vega

Viral delivery of exogenous coding sequences into the inner ear has the potential for therapeutic benefit for patients suffering genetic or acquired hearing loss. To devise improved strategies for viral delivery, we investigated two injection techniques, r ...

2020

Dissecting self-voice perception: From bone conduction to robotically-induced self-other voice misattribution in healthy listeners

Pavo Orepic

Inspired by the prominent theory suggesting that auditory-verbal hallucinations (AVH) - the sensation of hearing voices without present speakers - arise as misattribution of inner speech towards external agents, my thesis revolved around self-voice percept ...

EPFL2020

Human Cochlear Nucleus on 7 Tesla Diffusion Tensor Imaging: Insights Into Micro-anatomy and Function for Auditory Brainstem Implant Surgery

Nicolas Vachicouras

Objective:The cochlear nucleus (CN) is the target of the auditory brainstem implant (ABI). Most ABI candidates have Neurofibromatosis Type 2 (NF2) and distorted brainstem anatomy from bilateral vestibular schwannomas. The CN is difficult to characterize as ...

LIPPINCOTT WILLIAMS & WILKINS2020

Aliasing mitigation in optical microscopy of dynamic biological samples by use of temporally modulated color illumination and a standard RGB camera

Michael Stefan Daniel Liebling, Christian Jaques

Significance: Despite recent developments in microscopy, temporal aliasing can arise when imaging dynamic samples. Modern sampling frameworks, such as generalized sampling, mitigate aliasing but require measurement of temporally overlapping and potentially ...

SPIE Society of Photo-optical Instrumentation Engineers2020

Smaller, Faster & Lighter KNN Graph Constructions

Rachid Guerraoui, Anne-Marie Kermarrec, Olivier Ruas

We propose GoldFinger, a new compact and fast-to-compute binary representation of datasets to approximate Jaccard’s index. We illustrate the effectiveness of GoldFinger on the emblematic big data problem of K-Nearest-Neighbor (KNN) graph construction and s ...

2020

Fundamentals and perspectives of ultrafast photoferroic recording

Anna Pogrebna

The ability to switch ferroics (ferro-, ferri-, antiferromagnets, ferroelectrics, multiferroics) between two stable bit states is one of the keystones of modern data storage technology. Due to many new ideas, originating from fundamental research during th ...

2020

Graph-based regularization of inverse problems in imaging

Mattia Rossi

As of today, the extension of the human visual capabilities to machines remains both a cornerstone and an open challenge in the attempt to develop intelligent systems. On the one hand, the development of more and more sophisticated imaging devices, capable ...

EPFL2020

Generating optical pulses via a soliton state of an optical microresonator coupled with a chip based semiconductor laser

Tobias Kippenberg, Hairun Guo, Arslan Sajid Raja

A light pulse source (100), being adapted for generating repetitive optical pulses (1), comprises a continuous wave cw laser device (10) being arranged for providing cw laser light (2), an optical waveguide (20) being optically coupled with the cw laser de ...

2020

Biomedical optical techniques for intracochlear cellular imaging

Marilisa Romito

Imaging the inner ear microanatomy is of great importance for the assessment of the state of the cells responsible for sound detection. Hearing disorders are mainly due to a malfunction of the cochlea, the bone containing the cells inside the inner ear. Un ...

EPFL2019

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