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Darstellung und Abwandlung von Chlorfluorcyclopropanen : Ein gezielter Zugang zu Fluorallylalkoholen

Manfred Schlosser
1975
Journal Articles

Abstract

Cycloaddn. of ClFC.bul. to olefins RR1C:CHR2 (R = alkyl or substituted alkyl, e.g., Et, ClCH2, AcOCH2CH2CH2; R1 = H, Me, Et; R2 = H, Me) gave 1-chloro-1-fluorocyclopropanes; these were acetolyzed to RR1C:CFCHR2OAc, which were hydrolyzed to RR1C:CFCHR2OH. The convenience and efficiency of the cycloaddn. reaction, which takes place in a 2-phase system even in the presence of base-sensitive substituents, makes the process attractive for prepg. 2-fluoroallylic alcs. [on SciFinder (R)]

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Manfred Schlosser
1975
Journal Articles

Abstract

Official source

Related concepts (27)

Alkyl group

In organic chemistry, an alkyl group is an alkane missing one hydrogen. The term alkyl is intentionally unspecific to include many possible substitutions. An acyclic alkyl has the general formula of . A cycloalkyl group is derived from a cycloalkane by removal of a hydrogen atom from a ring and has the general formula . Typically an alkyl is a part of a larger molecule. In structural formulae, the symbol R is used to designate a generic (unspecified) alkyl group. The smallest alkyl group is methyl, with the formula .

Substitution reaction

A substitution reaction (also known as single displacement reaction or single substitution reaction) is a chemical reaction during which one functional group in a chemical compound is replaced by another functional group. Substitution reactions are of prime importance in organic chemistry. Substitution reactions in organic chemistry are classified either as electrophilic or nucleophilic depending upon the reagent involved, whether a reactive intermediate involved in the reaction is a carbocation, a carbanion or a free radical, and whether the substrate is aliphatic or aromatic.

Nucleophilic substitution

In chemistry, a nucleophilic substitution is a class of chemical reactions in which an electron-rich chemical species (known as a nucleophile) replaces a functional group within another electron-deficient molecule (known as the electrophile). The molecule that contains the electrophile and the leaving functional group is called the substrate.R. A. Rossi, R. H. de Rossi, Aromatic Substitution by the SRN1 Mechanism, ACS Monograph Series No. 178, American Chemical Society, 1983. .

Related publications (19)

Darstellung und Abwandlung von Chlorfluorcyclopropanen : Ein gezielter Zugang zu Fluorallylalkoholen

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