Publication

Asymmetric synthesis of the polyol subunit of the polyene macrolide antibiotic RK-397

Pierre Vogel, Sandrine Gerber, Kai Torsten Meilert
2006
Journal Articles

Abstract

A total asymmetric synthesis of the polyol subunit of the polyene macrolide antibiotic RK-397 was developed through the stereoselective functionalization of (1R,1’S,6S,6’R)-3,3’-methylenebis(cyclohept-3-ene-1,6-diol). The pathway generates a large variety of stereoisomeric intermediates and thus can be applied to the preparation of analogues of the natural antibiotic.

Official source

https://infoscience.epfl.ch/entities/publication/02fab732-cb02-4a3c-81ba-7f6098b4a5ee

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Asymmetric synthesis of the polyol subunit of the polyene macrolide antibiotic RK-397

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