Slow-Binding and Covalent HDAC Inhibition: A New Paradigm?

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Slow-Binding and Covalent HDAC Inhibition: A New Paradigm?

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Abstract 4588: Cell states and resistance in colorectal cancer: What can we learn from patient-derived organoids?

Nanomotion-Based Drug Sensitivity Prediction in Ovarian and Colon Cancer Cell Lines Using Machine Learning

Antibody-peptide conjugates deliver covalent inhibitors blocking oncogenic cathepsins

Distribution and diversity of classical deacylases in bacteria

Structural Basis of the Allosteric Inhibition of Human ABCG2 by Nanobodies

Translational screening platform to evaluate chemotherapy in combination with focal therapy for retinoblastoma

Simultaneous and Selective Detection of Etoposide and Methotrexate With Single Electrochemical Sensors for Therapeutic Drug Monitoring

Can Precision Electrophile Signaling Make a Meaningful and Lasting Impression in Drug Design?

Simultaneous mass spectrometry analysis of cisplatin with oligonucleotide-peptide mixtures: implications for the mechanism of action

Structures of ABCG2 under turnover conditions reveal a key step in the drug transport mechanism

Metabolic signature in nucleus accumbens for anti-depressant-like effects of acetyl-L-carnitine

The HDAC inhibitor SAHA improves depressive-like behavior of CRTC1-deficient mice: Possible relevance for treatment-resistant depression

The Molecular Basis for Dual Fatty Acid Amide Hydrolase (FAAH)/Cyclooxygenase (COX) Inhibition

Antiangiogenic and Anticancer Properties of Bifunctional Ruthenium(II)-p-Cymene Complexes: Influence of Pendant Perfluorous Chains

Structural Role of RKS Motifs in Chromatin Interactions: A Molecular Dynamics Study of HP1 Bound to a Variably Modified Histone Tail

Structurally Diverse Cyclisation Linkers Impose Different Backbone Conformations in Bicyclic Peptides