Alexandre Gauthier Aurèle Mayran

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The current pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected most of the world in a profound way. As an indirect consequence, the general public has been put into direct contact with the research process, almost ...

Understanding the interplay between cell fate specification and morphogenetic changes remains a challenge in developmental biology. Gastruloids, stem cell models of postimplantation mammalian development, provide a platform to address this question. Here, ...

Mammalian tail length is controlled by several genetic determinants, among which are Hox13 genes, whose function is to terminate the body axis. Accordingly, the precise timing in the transcriptional activation of these genes may impact upon body length. Un ...

Self-organization, such as the emergence of a pattern from a homogenous state, is a fascinating property of biological systems. Early limb bud outgrowth and patterning in mice are controlled by a robust and self-regulatory signaling system, and initiation ...

Hox genes encode transcription factors (TFs) that establish morphological diversity in the developing embryo. The similar DNA-binding motifs of the various HOX TFs contrast with the wide-range of HOX-dependent genetic programs. The influence of the chromat ...

Temporal activation of Hox genes in mouse pseudo-embryos in vitro initiates at the anterior part of the cluster and is accompanied by asymmetric loading of cohesin. Posterior CTCF sites then successively act as transient insulators, regulating the timed tr ...

Gastruloids are 3D structures generated from pluripotent stem cells recapitulating fundamental principles of embryonic pattern formation. Using single-cell genomic analysis, we provide a resource mapping cell states and types during gastruloid development ...

Alexandre Gauthier Aurèle Mayran

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Transgenic Model Systems Have Revolutionized the Study of Disease

Size-dependent temporal decoupling of morphogenesis and transcriptional programs in pseudoembryos

CTCF-dependent insulation of Hoxb13 and the heterochronic control of tail length

WNT signaling coordinately controls mouse limb bud outgrowth and establishment of the digit-interdigit pattern

HOX13-dependent chromatin accessibility underlies the transition towards the digit development program

Sequential and directional insulation by conserved CTCF sites underlies the Hox timer in stembryos

Multimodal characterization of murine gastruloid development