Publications by Wen Gao | EPFL Graph Search

Related publications (11)

Mfn1 Deficiency in the Liver Protects Against Diet-Induced Insulin Resistance and Enhances the Hypoglycemic Effect of Metformin

Carlos Canto Alvarez, Richardus Houtkooper, Patrick Descombes, Joanna Ratajczak, Catherine Maclachlan, Wen Gao

Mitochondrial function can be influenced by mitochondrial shape and connectivity with other cellular organelles through fusion and fission processes. Disturbances in mitochondrial architecture and mitochondrial fusion related genes are observed in situatio ...

American Diabetes Association2016

A lysosomal surveillance response to stress extends healthspan

Johan Auwerx, Xiaoxu Li, Yang Li, Tanes Imamura de Lima, Jia Liu, Wen Gao, Qi Wang, Amélia Lalou

Lysosomes are cytoplasmic organelles central for the degradation of macromolecules to maintain cellular homoeostasis and health. However, how lysosomal activity can be boosted to counteract ageing and ageing-related diseases remains elusive. Here we reveal ...

Springer Science and Business Media LLC2025

V-ATPase/TORC1-mediated ATFS-1 translation directs mitochondrial UPR activation in C. elegans

Johan Auwerx, Kristina Schoonjans, Felix Naef, Xiaoxu Li, Yang Li, Hao Li, Jia Liu, Yan Liu, Wen Gao, Amélia Lalou, Nagammal Neelagandan

To adapt mitochondrial function to the ever-changing intra- and extracellular environment, multiple mitochondrial stress response (MSR) pathways, including the mitochondrial unfolded protein response (UPRmt), have evolved. However, how the mitochondrial st ...

Rockefeller University Press2022

High-content phenotypic analysis of a C. elegans recombinant inbred population identifies genetic and molecular regulators of lifespan

Johan Auwerx, Laurent Mouchiroud, Maroun Bou Sleiman, Xiaoxu Li, Yang Li, Elena Katsyuba, Jean-David Horacio Morel, Wen Gao, Amélia Lalou, Jonathan Allen Sulc, Gaby El Alam

Lifespan is influenced by complex interactions between genetic and environmental factors. Studying those factors in model organisms of a single genetic background limits their translational value for humans. Here, we mapped lifespan determinants in 85 C. e ...

2024

Reduced ech-6 expression attenuates fat-induced lifespan shortening in C. elegans

Richardus Houtkooper, Yan Liu, Wen Gao

Deregulated energy homeostasis represents a hallmark of aging and results from complex gene-by-environment interactions. Here, we discovered that reducing the expression of the gene ech-6 encoding enoyl-CoA hydratase remitted fat diet-induced deleterious e ...

Nature Portfolio2022

Identifying gene function and module connections by the integration of multispecies expression compendia

Johan Auwerx, Stephan Morgenthaler, Kristina Schoonjans, Maroun Bou Sleiman, Yang Li, Elena Katsyuba, Hao Li, Fabrice David, Wen Gao, Qingyao Huang, Changmyung Oh, Daria Rukina

The functions of many eukaryotic genes are still poorly understood. Here, we developed and validated a new method, termed GeneBridge, which is based on two linked approaches to impute gene function and bridge genes with biological processes. First, Gene-Mo ...

Cold Spring Harbor Laboratory2019

Article Multi-omics analysis identifies essential regulators of mitochondrial stress response in two wild-type C. elegans strains

Johan Auwerx, Maroun Bou Sleiman, Yang Li, Wen Gao, Amélia Lalou, Gaby El Alam, Kevin Sebastiaan Hof

The mitochondrial unfolded protein response (UPRmt) is a promising pharmacological target for aging and age-related diseases. However, the integrative analysis of the impact of UPRmt activation on different signaling layers in animals with different geneti ...

CELL PRESS2022

Lysosomes mediate the mitochondrial UPR via mTORC1-dependent ATF4 phosphorylation

Johan Auwerx, Xiaoxu Li, Adrienne Joëlle Laurence Mottis, Yang Li, Wen Gao, Qi Wang

Lysosomes are central platforms for not only the degradation of macromolecules but also the integration of multiple signaling pathways. However, whether and how lysosomes mediate the mitochondrial stress response (MSR) remain largely unknown. Here, we demo ...

SPRINGERNATURE2023

Systems genetics of metabolic health in the BXD mouse genetic reference population

Johan Auwerx, Maroun Bou Sleiman, Xiaoxu Li, Jean-David Horacio Morel, Giorgia Benegiamo, Jia Liu, Wen Gao, Amélia Lalou, Alessia De Masi, Jonathan Allen Sulc, Johanne Gracia Anne Poisson

Susceptibility to metabolic syndrome (MetS) is dependent on genetics, environment, and gene-by-environment interactions, rendering the study of underlying mechanisms challenging. The majority of experiments in model organisms do not incorporate genetic var ...

2024

Distributed Video Coding: Trends and Perspectives

Frédéric Dufaux, Wen Gao

This paper surveys recent trends and perspectives in distributed video coding. More specifically, issues such as coding efficiency, error resilience, multi-view coding, scalability, and applications beyond coding are overviewed. In addition, recent contrib ...

Hindawi Publishing Corporation2009

Sex- and age-dependent genetics of longevity in a heterogeneous mouse population

Johan Auwerx, Maroun Bou Sleiman, Hao Li, Wen Gao, Giacomo Vincenzo Giorgio Von Alvensleben

American Association for the Advancement of Science2022