Publications by Giorgia Benegiamo

Related publications (13)

Safe and Orally Bioavailable Inhibitor of Serine Palmitoyltransferase Improves Age-Related Sarcopenia

Ioanna Daskalaki, Johan Auwerx, Jean-David Horacio Morel, Giorgia Benegiamo, Tanes Imamura de Lima, Sandra Rodriguez Lopez, Alessia De Masi, Johanne Gracia Anne Poisson

The accumulation of ceramides and related metabolites has emerged as a pivotal mechanism contributing to the onset of age-related diseases. However, small molecule inhibitors targeting the ceramide de novo synthesis pathway for clinical use are currently u ...

2025

Genetic and dietary modulators of the inflammatory response in the gastrointestinal tract of the BXD mouse genetic reference population

Johan Auwerx, Kristina Schoonjans, Maroun Bou Sleiman, Alessia Perino, Xiaoxu Li, Jean-David Horacio Morel, Giorgia Benegiamo, Alexis Rapin, Alexis Maximilien Bachmann, Jonathan Allen Sulc, Johanne Gracia Anne Poisson

Inflammatory gut disorders, including inflammatory bowel disease (IBD), can be impacted by dietary, environmental, and genetic factors. While the incidence of IBD is increasing worldwide, we still lack a complete understanding of the gene-by-environment in ...

2023

Genome-wide allele-specific expression in multi-tissue samples from healthy male baboons reveals the transcriptional complexity of mammals

Giorgia Benegiamo

Allele-specific expression (ASE) is pivotal in understanding the genetic underpinnings of phenotypic variation within species, differences in disease susceptibility, and responses to environmental factors. We processed 11 different tissue types collected f ...

2025

The exercise-induced long noncoding RNA CYTOR promotes fast-twitch myogenesis in aging

Johan Auwerx, Giorgia Benegiamo, Tanes Imamura de Lima, Pirkka-Pekka Untamo Laurila, Martin Rainer Wohlwend, Mario Romani

Skeletal muscle displays remarkable plasticity upon exercise and is also one of the organs most affected by aging. Despite robust evidence that aging is associated with loss of fast-twitch (type II) muscle fibers, the underlying mechanisms remain to be elu ...

2021

Asperuloside Improves Obesity and Type 2 Diabetes through Modulation of Gut Microbiota and Metabolic Signaling

Johan Auwerx, Giorgia Benegiamo

Asperuloside (ASP) is an iridoid glycoside that is extracted from Eucommia leaves. Eucommia is used in traditional Chinese medicine and has a long history of benefits on health and longevity. Here, we investigated the impact of ASP on obesity-related metab ...

2020

Sodium ferrous citrate and 5-aminolevulinic acid improve type 2 diabetes by maintaining muscle and mitochondrial health

Johan Auwerx, Jean-David Horacio Morel, Giorgia Benegiamo

ObjectiveImproving mitochondrial function is a promising strategy for intervention in type 2 diabetes mellitus. This study investigated the preventive effects of sodium ferrous citrate (SFC) and 5-aminolevulinic acid phosphate (ALA) on several metabolic dy ...

WILEY2023

Failure of metabolic checkpoint control during late-stage granulopoiesis drives neutropenia in reticular dysgenesis

Johan Auwerx, Giorgia Benegiamo, Ludger Jan Elzuë Goeminne

Cellular metabolism is highly dynamic during hematopoiesis, yet the regulatory networks that maintain metabolic homeostasis during differentiation are incompletely understood. Herein, we have studied the grave immunodeficiency syndrome reticular dysgenesis ...

2024

COX7A2L genetic variants determine cardiorespiratory fitness in mice and human

Johan Auwerx, Maroun Bou Sleiman, Pooja Jha, Giorgia Benegiamo, Ludger Jan Elzuë Goeminne, Pirkka-Pekka Untamo Laurila, Martin Rainer Wohlwend, Sandra Rodriguez Lopez

Benegiamo et al. identify genetic variants of the mitochondrial supercomplex assembly factor COX7A2L in the skeletal muscle of mice and humans that promote cardiorespiratory fitness. ...

NATURE PORTFOLIO2022

Wars1 downregulation in hepatocytes induces mitochondrial stress and disrupts metabolic homeostasis

Johan Auwerx, Kristina Schoonjans, Alessia Perino, Xiaoxu Li, Giorgia Benegiamo, Hadrien Charles Edouard Demagny, Antoine Jalil, Francesca Pontanari, Adrien Faure Garcia

Several laboratories, including ours, have employed the Slc25a47tm1c(EUCOMM)Hmgu mouse model to investigate the role of SLC25A47, a hepatocyte-specific mitochondrial carrier, in regulating hepatic metabolism and systemic physiology. In this study, we revea ...

2025

Systems genetics of metabolic health in the BXD mouse genetic reference population

Johan Auwerx, Maroun Bou Sleiman, Xiaoxu Li, Jean-David Horacio Morel, Giorgia Benegiamo, Jia Liu, Wen Gao, Amélia Lalou, Alessia De Masi, Jonathan Allen Sulc, Johanne Gracia Anne Poisson

Susceptibility to metabolic syndrome (MetS) is dependent on genetics, environment, and gene-by-environment interactions, rendering the study of underlying mechanisms challenging. The majority of experiments in model organisms do not incorporate genetic var ...

2024

The Genetic Background Shapes Disease Susceptibility And Reveals A Specific Role For Mitochondrial Dysfunction In The Progression From Nafld To Nash

Johan Auwerx, Maroun Bou Sleiman, Jean-David Horacio Morel, Giorgia Benegiamo, Jia Liu, Sandra Rodriguez Lopez, Giacomo Vincenzo Giorgio Von Alvensleben, Alexis Maximilien Bachmann

WILEY2022

The genetic background shapes the susceptibility to mitochondrial dysfunction and NASH progression

Johan Auwerx, Maroun Bou Sleiman, Jean-David Horacio Morel, Giorgia Benegiamo, Ludger Jan Elzuë Goeminne, Sandra Rodriguez Lopez, Giacomo Vincenzo Giorgio Von Alvensleben, Alexis Maximilien Bachmann

Mice from different genetic backgrounds have widely diverse responses to the same metabolic challenges. Only PWK/PhJ mice show significant mitochondrial dysfunction and progression to fibrotic NASH that resembles human NASH. The PWK/PhJ strain is a novel N ...

ROCKEFELLER UNIV PRESS2023

Gene replacement therapy provides benefit in an adult mouse model of Leigh syndrome

Johan Auwerx, Giorgia Benegiamo

Mutations in nuclear-encoded mitochondrial genes are responsible for a broad spectrum of disorders among which Leigh syndrome is the most common in infancy. No effective therapies are available for this severe disease mainly because of the limited capabili ...

2020