Publication

The genetic background shapes the susceptibility to mitochondrial dysfunction and NASH progression

Johan Auwerx, Maroun Bou Sleiman, Giorgia Benegiamo, Jean-David Horacio Morel, Ludger Jan Elzuë Goeminne, Sandra Rodriguez Lopez, Giacomo Vincenzo Giorgio Von Alvensleben, Alexis Maximilien Bachmann
2023
Journal Articles

Abstract

Mice from different genetic backgrounds have widely diverse responses to the same metabolic challenges. Only PWK/PhJ mice show significant mitochondrial dysfunction and progression to fibrotic NASH that resembles human NASH. The PWK/PhJ strain is a novel NASH mouse model.

Official source

https://infoscience.epfl.ch/entities/publication/488c4d26-5083-4499-86fb-859df8b6ea87

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The genetic background shapes the susceptibility to mitochondrial dysfunction and NASH progression

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