Publications by Jordan Squair | EPFL Graph Search

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Astrocytes are essential for the development and homeostatic maintenance of the central nervous system (CNS). They are also critical players in the CNS injury response during which they undergo a process referred to as "reactive astrogliosis." Diversity in ...

Spinal cord injury (SCI) induces haemodynamic instability that threatens survival(1-3), impairs neurological recovery(4,5), increases the risk of cardiovascular disease(6,7), and reduces quality of life(8,9). Haemodynamic instability in this context is due ...

Axon regeneration can be induced across anatomically complete spinal cord injury (SCI), but robust functional restoration has been elusive. Whether restoring neurological functions requires directed regeneration of axons from specific neuronal subpopulatio ...

A spinal cord injury interrupts pathways from the brain and brainstem that project to the lumbar spinal cord, leading to paralysis. Here we show that spatiotemporal epidural electrical stimulation (EES) of the lumbar spinal cord(1-3) applied during neurore ...

Micro- and nanoscale metallic glasses offer exciting opportunities for both fundamental research and applications in healthcare, micro-engineering, optics and electronics. The scientific and technological challenges associated with the fabrication and util ...

Teravoxel-scale, cellular-resolution images of cleared rodent brains acquired with light-sheet fluorescence microscopy have transformed the way we study the brain. Realizing the potential of this technology requires computational pipelines that generalize ...

A neuromodulation system (10,110) is disclosed, especially a neurostimulation system (10,110), for treating a patient, especially for enhancing at least one autonomous function such a blood circulation and/or respiration, wherein the system comprises • - a ...

The cell types affected by biological perturbations in complex tissues are uncovered by single-cell analysis. ...

The present invention relates to a neuromodulation/neurostimulation system (10) for stimulating at least one neuronal circuitry responsible for micturition control in a mammal with bladder disfunction, especially for bladder relaxation and/or for bladder v ...

An implantable blood pressure monitor has two or more elements configured to wrap at least part way around a blood vessel. Changes in pressure within the blood vessel may be sensed by detecting movements of the elements or forces applied to the elements. A ...

The present invention relates to a combined neuromodulation and/or neurostimulation system (10) for mitigating locomotor deficits of/or neuronal disorders, especially Parkinson's disease, said system (10) comprising: - at least one Deep Brain Stimulation ( ...

Differential expression analysis of single-cell transcriptomics allows scientists to dissect cell-type-specific responses to biological perturbations. Here, the authors show that many commonly used methods are biased and can produce false discoveries. ...

People with late-stage Parkinson's disease (PD) often suffer from debilitating locomotor deficits that are resistant to currently available therapies. To alleviate these deficits, we developed a neuroprosthesis operating in closed loop that targets the dor ...

Differential accessibility (DA) analysis of single-cell epigenomics data enables the discovery of regulatory programs that establish cell type identity and steer responses to physiological and pathophysiological perturbations. While many statistical method ...

A system (10) for neuromodulation and/or neurostimulation, for the treatment of a mammal, at least comprising: - at least one control unit (12) configured and arranged to provide stimulation data; - at least one stimulation unit (14) configured and arrange ...

The invention provides pharmaceutical compositions, combinations and vectors, such as expression vectors, as well as use thereof in a method for central nervous system repair after neurotrauma, such as spinal cord injury (SCI) or stroke and in a method for ...

Jordan Squair

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Diversity of Reactive Astrogliosis in CNS Pathology: Heterogeneity or Plasticity?

Neuroprosthetic baroreflex controls haemodynamics after spinal cord injury

Recovery of walking after paralysis by regenerating characterized neurons to their natural target region

The neurons that restore walking after paralysis

Structured nanoscale metallic glass fibres with extreme aspect ratios

A deep learning pipeline for three-dimensional brain-wide mapping of local neuronal ensembles in teravoxel light-sheet microscopy

System for closed loop control of autonomic function

Cell type prioritization in single-cell data

System for micturition control in a mammal with bladder disfunction

Implantable blood pressure monitor

Neuromodulation/neurostimulation system for mitigating locomotor deficits of parkinson's disease, spinal cord injury (sci), stroke and/or other neurological disorders

Confronting false discoveries in single-cell differential expression

A spinal cord neuroprosthesis for locomotor deficits due to Parkinson's disease

Best practices for differential accessibility analysis in single-cell epigenomics

System and method for control of autonomic function

Transcriptional Dynamics Of Neurorehabilitation In Spinal Cord Injury At Single-Nucleus Resolution

Neurotrauma treatment

Invisible consequences of paralysis