Publications by Jordan Squair | EPFL Graph Search

Related publications (26)

Diversity of Reactive Astrogliosis in CNS Pathology: Heterogeneity or Plasticity?

Astrocytes are essential for the development and homeostatic maintenance of the central nervous system (CNS). They are also critical players in the CNS injury response during which they undergo a process referred to as "reactive astrogliosis." Diversity in ...

2021

Neuroprosthetic baroreflex controls haemodynamics after spinal cord injury

Stéphanie Lacour, Grégoire Courtine, Marco Capogrosso, Jocelyne Bloch, Giuseppe Schiavone, Florian Dylan Fallegger, Nicolas Vachicouras, Quentin Barraud, Jordan Squair, Ileana Ozana Jelescu, Eduardo Martin Moraud, Fabien Bertrand Paul Wagner, Robin Jonathan Demesmaeker, Claudia Kathe, Matthieu Pierre Gautier, Mark Andrew Anderson, Newton Cho, Nicholas David James, Salif Axel Komi, Jimmy James Ravier, Jérôme Gandar, Andreas Rowald, Kay Alexander Bartholdi, Charlotte Marie Jacques Moerman, Achilleas Laskaratos, Laura Ann McCracken, Loïs Thomas Romain Mahe, Arnaud Bichat

Spinal cord injury (SCI) induces haemodynamic instability that threatens survival(1-3), impairs neurological recovery(4,5), increases the risk of cardiovascular disease(6,7), and reduces quality of life(8,9). Haemodynamic instability in this context is due ...

NATURE RESEARCH2021

Recovery of walking after paralysis by regenerating characterized neurons to their natural target region

Grégoire Courtine, Bernard Schneider, Jocelyne Bloch, Quentin Barraud, Jordan Squair, Claudia Kathe, Matthieu Pierre Gautier, Katia Galan, Mark Andrew Anderson, Newton Cho, Nicholas David James, Thomas Haynes Hutson, Laetitia Danielle Philippine Baud, Michael Alexander Skinnider, Achilleas Laskaratos, Marco Milano, Steven Lee Ceto, Anna Lasne

Axon regeneration can be induced across anatomically complete spinal cord injury (SCI), but robust functional restoration has been elusive. Whether restoring neurological functions requires directed regeneration of axons from specific neuronal subpopulatio ...

American Association for the Advancement of Science2023

The neurons that restore walking after paralysis

Ruijia Wang, Stéphanie Lacour, Grégoire Courtine, Jocelyne Bloch, Quentin Barraud, Jordan Squair, Léonie Asboth, Fabien Bertrand Paul Wagner, Robin Jonathan Demesmaeker, Claudia Kathe, Matthieu Pierre Gautier, Kyungjin Kim, Katia Galan, Newton Cho, Nicholas David James, Thomas Haynes Hutson, Salif Axel Komi, Laetitia Danielle Philippine Baud, Andreas Rowald, Steven Lee Ceto, Nicola Aldo Regazzi

A spinal cord injury interrupts pathways from the brain and brainstem that project to the lumbar spinal cord, leading to paralysis. Here we show that spatiotemporal epidural electrical stimulation (EES) of the lumbar spinal cord(1-3) applied during neurore ...

NATURE PORTFOLIO2022

Structured nanoscale metallic glass fibres with extreme aspect ratios

Stéphanie Lacour, Grégoire Courtine, Fabien Sorin, Vasiliki Tileli, Giuseppe Schiavone, Wei Yan, Jordan Squair, Yunpeng Qu, Dang Tùng Nguyen, Reinis Ignatans, Güven Kurtuldu, Inès Richard, Nicholas David James

Micro- and nanoscale metallic glasses offer exciting opportunities for both fundamental research and applications in healthcare, micro-engineering, optics and electronics. The scientific and technological challenges associated with the fabrication and util ...

Nature Publishing Group2020

Single cell atlas of spinal cord injury in mice reveals a pro-regenerative signature in spinocerebellar neurons

Grégoire Courtine, Jordan Squair, Claudia Kathe

After spinal cord injury, tissue distal to the lesion contains undamaged cells that could support or augment recovery. Targeting these cells requires a clearer understanding of their injury responses and capacity for repair. Here, we use single nucleus RNA ...

Nature Portfolio2022

Longitudinal interrogation of sympathetic neural circuits and hemodynamics in preclinical models

Victor Perez Puchalt, Jan Elaine Cuevas Soriano, Grégoire Courtine, Quentin Barraud, Jordan Squair, Matthieu Pierre Gautier, Loïs Thomas Romain Mahe, Rémi Bernard René Hudelle, Suje Amir

Neurological disorders, including spinal cord injury, result in hemodynamic instability due to the disruption of supraspinal projections to the sympathetic circuits located in the spinal cord. We recently developed a preclinical model that allows the ident ...

NATURE PORTFOLIO2022

Prioritization of cell types responsive to biological perturbations in single-cell data with Augur

Grégoire Courtine, Jordan Squair, Matthieu Pierre Gautier, Michael Alexander Skinnider

Advances in single-cell genomics now enable large-scale comparisons of cell states across two or more experimental conditions. Numerous statistical tools are available to identify individual genes, proteins or chromatin regions that differ between conditio ...

NATURE RESEARCH2021

A deep learning pipeline for three-dimensional brain-wide mapping of local neuronal ensembles in teravoxel light-sheet microscopy

Grégoire Courtine, Jordan Squair, Newton Cho

Teravoxel-scale, cellular-resolution images of cleared rodent brains acquired with light-sheet fluorescence microscopy have transformed the way we study the brain. Realizing the potential of this technology requires computational pipelines that generalize ...

Nature Publishing Group2025

Non-invasive spinal cord electrical stimulation for arm and hand function in chronic tetraplegia: a safety and efficacy trial

Grégoire Courtine, Jordan Squair

Cervical spinal cord injury (SCI) leads to permanent impairment of arm and hand functions. Here we conducted a prospective, single-arm, multicenter, open-label, non-significant risk trial that evaluated the safety and efficacy of ARCEX Therapy to improve a ...

Nature Portfolio2024

System for closed loop control of autonomic function

Grégoire Courtine, Jordan Squair

A neuromodulation system (10,110) is disclosed, especially a neurostimulation system (10,110), for treating a patient, especially for enhancing at least one autonomous function such a blood circulation and/or respiration, wherein the system comprises • - a ...

2020

Cell type prioritization in single-cell data

Grégoire Courtine, Gioele La Manno, Quentin Barraud, Jordan Squair, Claudia Kathe, Matthieu Pierre Gautier, Mark Andrew Anderson, Thomas Haynes Hutson, Michael Alexander Skinnider, Marco Milano

The cell types affected by biological perturbations in complex tissues are uncovered by single-cell analysis. ...

NATURE PUBLISHING GROUP2021

System for micturition control in a mammal with bladder disfunction

Grégoire Courtine, Jocelyne Bloch, Jordan Squair, Loïs Thomas Romain Mahe

The present invention relates to a neuromodulation/neurostimulation system (10) for stimulating at least one neuronal circuitry responsible for micturition control in a mammal with bladder disfunction, especially for bladder relaxation and/or for bladder v ...

2024

Implantable blood pressure monitor

Grégoire Courtine, Jordan Squair

An implantable blood pressure monitor has two or more elements configured to wrap at least part way around a blood vessel. Changes in pressure within the blood vessel may be sensed by detecting movements of the elements or forces applied to the elements. A ...

2021

Neuromodulation/neurostimulation system for mitigating locomotor deficits of parkinson's disease, spinal cord injury (sci), stroke and/or other neurological disorders

Grégoire Courtine, Jocelyne Bloch, Jordan Squair, Eduardo Martin Moraud, Léonie Asboth, Robin Jonathan Demesmaeker, Tomislav Milekovic, Newton Cho

The present invention relates to a combined neuromodulation and/or neurostimulation system (10) for mitigating locomotor deficits of/or neuronal disorders, especially Parkinson's disease, said system (10) comprising: - at least one Deep Brain Stimulation ( ...

2023

Confronting false discoveries in single-cell differential expression

Grégoire Courtine, Gioele La Manno, Quentin Barraud, Jordan Squair, Matthieu Pierre Gautier, Mark Andrew Anderson, Nicholas David James, Thomas Haynes Hutson, Claudia Kathe, Michael Alexander Skinnider, Rémi Bernard René Hudelle

Differential expression analysis of single-cell transcriptomics allows scientists to dissect cell-type-specific responses to biological perturbations. Here, the authors show that many commonly used methods are biased and can produce false discoveries. ...

Nature Portfolio2021

A spinal cord neuroprosthesis for locomotor deficits due to Parkinson's disease

Jean François Pierre Laurens, Auke Ijspeert, Silvestro Micera, Stéphanie Lacour, Grégoire Courtine, Marco Capogrosso, Jocelyne Bloch, Giuseppe Schiavone, Elvira Pirondini, Jordan Squair, Eduardo Martin Moraud, Léonie Asboth, Robin Jonathan Demesmaeker, Tomislav Milekovic, Jimmy James Ravier, Jean-Baptiste Mignardot, Flavio Raschella, Simon Borgognon, Alice Julie Bruel, Carmina Andrea Galvez Solano, Camille Georgette Marie Le Goff-Mignardot, Charlotte Marie Jacques Moerman, David Allenson Borton, Grégory Didier Dumont, Sergio Daniel Hernandez, Nicolò Macellari, Shiqi Sun

People with late-stage Parkinson's disease (PD) often suffer from debilitating locomotor deficits that are resistant to currently available therapies. To alleviate these deficits, we developed a neuroprosthesis operating in closed loop that targets the dor ...

Nature Portfolio2023

Natural and targeted circuit reorganization after spinal cord injury

Grégoire Courtine, Jocelyne Bloch, Quentin Barraud, Jordan Squair, Claudia Kathe, Matthieu Pierre Gautier, Mark Andrew Anderson, Thomas Haynes Hutson

The authors summarize changes in circuits after spinal cord injury and current strategies to target these circuits in order to improve recovery, but also advocate for new concepts of reorganizing circuits informed by multi-omic single-cell atlases. ...

NATURE PORTFOLIO2022

Best practices for differential accessibility analysis in single-cell epigenomics

Grégoire Courtine, Jordan Squair, Michael Alexander Skinnider

Differential accessibility (DA) analysis of single-cell epigenomics data enables the discovery of regulatory programs that establish cell type identity and steer responses to physiological and pathophysiological perturbations. While many statistical method ...

Nature Research2024

Engineering spinal cord repair

Grégoire Courtine, Jordan Squair, Matthieu Pierre Gautier, Mark Andrew Anderson, Michael V. Sofroniew

Neurological damage caused by spinal cord injury in humans has been observed for over three thousand years and impacts the lives of several hundred thousand people worldwide. Despite this prevalence and its associated consequences, there is no treatment to ...

CURRENT BIOLOGY LTD2021