Publications by Jocelyne Bloch

Related publications (56)

Neuroprosthetic baroreflex controls haemodynamics after spinal cord injury

Stéphanie Lacour, Grégoire Courtine, Marco Capogrosso, Jocelyne Bloch, Giuseppe Schiavone, Florian Dylan Fallegger, Nicolas Vachicouras, Quentin Barraud, Jordan Squair, Ileana Ozana Jelescu, Eduardo Martin Moraud, Fabien Bertrand Paul Wagner, Robin Jonathan Demesmaeker, Claudia Kathe, Matthieu Pierre Gautier, Mark Andrew Anderson, Newton Cho, Nicholas David James, Salif Axel Komi, Jimmy James Ravier, Jérôme Gandar, Andreas Rowald, Kay Alexander Bartholdi, Charlotte Marie Jacques Moerman, Achilleas Laskaratos, Laura Ann McCracken, Loïs Thomas Romain Mahe, Arnaud Bichat

Spinal cord injury (SCI) induces haemodynamic instability that threatens survival(1-3), impairs neurological recovery(4,5), increases the risk of cardiovascular disease(6,7), and reduces quality of life(8,9). Haemodynamic instability in this context is due ...

NATURE RESEARCH2021

Recovery of walking after paralysis by regenerating characterized neurons to their natural target region

Grégoire Courtine, Bernard Schneider, Jocelyne Bloch, Quentin Barraud, Jordan Squair, Claudia Kathe, Matthieu Pierre Gautier, Katia Galan, Mark Andrew Anderson, Newton Cho, Nicholas David James, Thomas Haynes Hutson, Laetitia Danielle Philippine Baud, Michael Alexander Skinnider, Achilleas Laskaratos, Marco Milano, Steven Lee Ceto, Anna Lasne

Axon regeneration can be induced across anatomically complete spinal cord injury (SCI), but robust functional restoration has been elusive. Whether restoring neurological functions requires directed regeneration of axons from specific neuronal subpopulatio ...

American Association for the Advancement of Science2023

Neuroenergetic Response to Prolonged Cerebral Glucose Depletion after Severe Brain Injury and the Role of Lactate

Pierre Magistretti, Jocelyne Bloch

Lactate may represent a supplemental fuel for the brain. We examined cerebral lactate metabolism during prolonged brain glucose depletion (GD) in acute brain injury (ABI) patients monitored with cerebral microdialysis (CMD). Sixty episodes of GD (defined a ...

Mary Ann Liebert2015

Low-Intensity Focused Ultrasound Neuromodulation for Stroke Recovery: A Novel Deep Brain Stimulation Approach for Neurorehabilitation?

Grégoire Courtine, Friedhelm Christoph Hummel, Jocelyne Bloch, Estelle Emeline Raffin, Shiqi Sun, Mahmut Yüksel

Stroke as the leading cause of adult long-term disability and has a significant impact on patients, society and socio-economics. Non-invasive brain stimulation (NIBS) approaches such as transcranial magnetic stimulation (TMS) or transcranial electrical sti ...

Ieee-Inst Electrical Electronics Engineers Inc2023

Hypothalamic deep brain stimulation augments walking after spinal cord injury

Nadia Bérard, Michael Hodara, Kristina Sveistyte, Anna Leonhartsberger, Grégoire Courtine, Jocelyne Bloch, Quentin Barraud, Léonie Asboth, Robin Jonathan Demesmaeker, Claudia Kathe, Matthieu Pierre Gautier, Katia Galan, Mark Andrew Anderson, Newton Cho, Nicholas David James, Thomas Haynes Hutson, Jimmy James Ravier, Laetitia Danielle Philippine Baud, Kay Alexander Bartholdi, Achilleas Laskaratos, Camille Claire Varescon, Nicolas Hankov, Inssia Dewany, Nadine Intering, Viviana Aureli, Frédéric Norbert Merlos

A spinal cord injury (SCI) disrupts the neuronal projections from the brain to the region of the spinal cord that produces walking, leading to various degrees of paralysis. Here, we aimed to identify brain regions that steer the recovery of walking after i ...

NATURE PORTFOLIO2024

A brain-spine interface alleviating gait deficits after spinal cord injury in primates

Silvestro Micera, Grégoire Courtine, Jocelyne Bloch, Marco Capogrosso, Quentin Barraud, Eduardo Martin Moraud, Fabien Bertrand Paul Wagner, Jérôme Gandar, Jean-Baptiste Mignardot, Tomislav Milekovic, David Allenson Borton, Elodie Rey

Spinal cord injury disrupts the communication between the brain and the spinal circuits that orchestrate movement. To bypass the lesion, brain-computer interfaces(1-3) have directly linked cortical activity to electrical stimulation of muscles, and have th ...

Nature Publishing Group2016

Activity-dependent spinal cord neuromodulation rapidly restores trunk and leg motor functions after complete paralysis

Dimitri Nestor Alice Van De Ville, Silvestro Micera, Grégoire Courtine, Marco Capogrosso, Jocelyne Bloch, Quentin Barraud, Nawal Noëlle Kinany, Léonie Asboth, Fabien Bertrand Paul Wagner, Robin Jonathan Demesmaeker, Salif Axel Komi, Jimmy James Ravier, Henri Charles Alexandre Lorach, Andreas Rowald, Miroslav Caban, Nathan Antoine Greiner, Carmina Andrea Galvez Solano, Sergio Daniel Hernandez, Laura Ann McCracken, Edeny Baaklini

Epidural electrical stimulation (EES) targeting the dorsal roots of lumbosacral segments restores walking in people with spinal cord injury (SCI). However, EES is delivered with multielectrode paddle leads that were originally designed to target the dorsal ...

NATURE PORTFOLIO2022

Spatiotemporal neuromodulation therapies engaging muscle synergies improve motor control after spinal cord injury

Silvestro Micera, Stéphanie Lacour, Grégoire Courtine, Jocelyne Bloch, Marco Capogrosso, Quentin Barraud, Eduardo Martin Moraud, Ivan Rusev Minev, Léonie Asboth, Jérôme Gandar, Nikolaus Wenger, Arthur Edouard Hirsch, Pavel Musienko, Laetitia Danielle Philippine Baud, Natalia Pavlova, Julie Kreider

Electrical neuromodulation of lumbar segments improves motor control after spinal cord injury in animal models and humans. However, the physiological principles underlying the effect of this intervention remain poorly understood, which has limited the ther ...

Nature Publishing Group2016

Hypertonic Lactate to Improve Cerebral Perfusion and Glucose Availability After Acute Brain Injury

Pierre Magistretti, Jocelyne Bloch

Objectives: Lactate promotes cerebral blood flow and is an efficient substrate for the brain, particularly at times of glucose shortage. Hypertonic lactate is neuroprotective after experimental brain injury; however, human data are limited. ...

LIPPINCOTT WILLIAMS & WILKINS2018

Automatic target validation based on neuroscientific literature mining for tractography

Jean-Cédric Chappelier, Jocelyne Bloch, Sean Lewis Hill, Renaud Luc Richardet

Target identification for tractography studies requires solid anatomical knowledge validated by an extensive literature review across species for each seed structure to be studied. Manual literature review to identify targets for a given seed region is ted ...

Frontiers Research Foundation2015

System for selective spatiotemporal stimulation of the spinal cord

Silvestro Micera, Grégoire Courtine, Marco Capogrosso, Jocelyne Bloch, Nikolaus Wenger

The present disclosure refers to systems for electrical neurostimulation of a spinal cord of a subject in need of nervous system function support. In one example, a system comprises a signal processing device configured to receive signals from the subject ...

2019

Neuromodulation/neurostimulation system for restoring a motor function and facilitating neurological recovery

Grégoire Courtine, Jocelyne Bloch, Henri Charles Alexandre Lorach

The present invention relates to a neuromodulation/neurostimulation system (100) for restoring a motor function of the upper and/or lower limbs and facilitating neurological recovery in a patient (P) with spinal cord injury (SCI) and/or other neurological ...

2024

The neurons that restore walking after paralysis

Ruijia Wang, Stéphanie Lacour, Grégoire Courtine, Jocelyne Bloch, Quentin Barraud, Jordan Squair, Léonie Asboth, Fabien Bertrand Paul Wagner, Robin Jonathan Demesmaeker, Claudia Kathe, Matthieu Pierre Gautier, Kyungjin Kim, Katia Galan, Newton Cho, Nicholas David James, Thomas Haynes Hutson, Salif Axel Komi, Laetitia Danielle Philippine Baud, Andreas Rowald, Steven Lee Ceto, Nicola Aldo Regazzi

A spinal cord injury interrupts pathways from the brain and brainstem that project to the lumbar spinal cord, leading to paralysis. Here we show that spatiotemporal epidural electrical stimulation (EES) of the lumbar spinal cord(1-3) applied during neurore ...

NATURE PORTFOLIO2022

Cerebral metabolic effects of exogenous lactate supplementation on the injured human brain

Pierre Magistretti, Reto Meuli, Jocelyne Bloch

Experimental evidence suggests that lactate is neuroprotective after acute brain injury; however, data in humans are lacking. We examined whether exogenous lactate supplementation improves cerebral energy metabolism in humans with traumatic brain injury (T ...

Springer Verlag2014

MGMT methylation analysis of glioblastoma on the Infinium methylation BeadChip identifies two distinct CpG regions associated with gene silencing and outcome, yielding a prediction model for comparisons across datasets, tumor grades, and CIMP-status

Jocelyne Bloch, Mauro Delorenzi

The methylation status of the O-6-methylguanine-DNA methyltransferase (MGMT) gene is an important predictive biomarker for benefit from alkylating agent therapy in glioblastoma. Recent studies in anaplastic glioma suggest a prognostic value for MGMT methyl ...

Springer-Verlag2012

Selective Recruitment of Arm Motoneurons in Nonhuman Primates Using Epidural Electrical Stimulation of the Cervical Spinal Cord

Stéphanie Lacour, Grégoire Courtine, Marco Capogrosso, Jocelyne Bloch, Giuseppe Schiavone

Recovery of reaching and grasping ability is the priority for people with cervical spinal cord injury (SCI). Epidural electrical stimulation (EES) has shown promising results in improving motor control after SCI in various animal models and in humans. Nota ...

2018

Configuration of electrical spinal cord stimulation through real-time processing of gait kinematics

Grégoire Courtine, Jocelyne Bloch, Marco Capogrosso, Pavel Musienko, Eduardo Martin Moraud, Nikolaus Wenger, Fabien Bertrand Paul Wagner, Tomislav Milekovic, Jérôme Gandar, Natalia Pavlova

Epidural electrical stimulation (EES) of the spinal cord and real-time processing of gait kinematics are powerful methods for the study of locomotion and the improvement of motor control after injury or in neurological disorders. Here, we describe equipmen ...

Nature Publishing Group2018

Electrical spinal cord stimulation must preserve proprioception to enable locomotion in humans with spinal cord injury

Silvestro Micera, Grégoire Courtine, Jocelyne Bloch, Marco Capogrosso, Fabien Bertrand Paul Wagner, Karen Minassian, Emanuele Formento, Jean-Baptiste Mignardot, Andreas Rowald, Camille Georgette Marie Le Goff-Mignardot

Epidural electrical stimulation (EES) of the spinal cord restores locomotion in animal models of spinal cord injury but is less effective in humans. Here we hypothesized that this interspecies discrepancy is due to interference between EES and propriocepti ...

2018

High-resolution prosthetic hearing with a soft auditory brainstem implant in macaques

Stéphanie Lacour, Jocelyne Bloch, Florian Dylan Fallegger, Ivan Furfaro, Alix Esther Anne Trouillet, Florent-Valéry Coen, Emilie Cornelia Maria Revol, Laurine Kolly

Individuals with compromised cochlear nerves are ineligible for cochlear implants and instead rely on auditory brainstem implants (ABIs). Most users of ABIs experience sound awareness, which aids in lip reading, yet not speech intelligibility. Here we engi ...

2025

Augmenting rehabilitation robotics with spinal cord neuromodulation: A proof of concept

Margaux Roulet, Francesco Acquati, Cathal John Harte, Auke Ijspeert, Grégoire Courtine, Jocelyne Bloch, Léonie Asboth, Fabien Bertrand Paul Wagner, Robin Jonathan Demesmaeker, Salif Axel Komi, Jimmy James Ravier, Henri Charles Alexandre Lorach, Miroslav Caban, Camille Claire Varescon, Nicolas Hankov, Edeny Baaklini, Nadine Intering, Frédéric Norbert Merlos

Rehabilitation robotics aims to promote activity-dependent reorganization of the nervous system. However, people with paralysis cannot generate sufficient activity during robot-assisted rehabilitation and, consequently, do not benefit from these therapies. ...

AMER ASSOC ADVANCEMENT SCIENCE2025