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Jocelyne Bloch

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Related publications (57)

Natural and targeted circuit reorganization after spinal cord injury

Grégoire Courtine, Quentin Barraud, Mark Andrew Anderson, Jocelyne Bloch, Claudia Kathe, Jordan Squair, Matthieu Pierre Gautier, Thomas Haynes Hutson

The authors summarize changes in circuits after spinal cord injury and current strategies to target these circuits in order to improve recovery, but also advocate for new concepts of reorganizing circuits informed by multi-omic single-cell atlases. ...

NATURE PORTFOLIO2022

Implanted System for Orthostatic Hypotension in Multiple-System Atrophy

Léonie Asboth, Maxime Berney, Grégoire Courtine, Nicolas Hankov, Robin Jonathan Demesmaeker, Jocelyne Bloch, Sergio Daniel Hernandez, Jordan Squair, Grégory Didier Dumont, Suje Amir

Orthostatic hypotension is a cardinal feature of multiple-system atrophy. The upright posture provokes syncopal episodes that prevent patients from standing and walking for more than brief periods. We implanted a system to restore regulation of blood press ...

MASSACHUSETTS MEDICAL SOC2022

Brain-spine interfaces to reverse paralysis

Grégoire Courtine, Jocelyne Bloch, Henri Charles Alexandre Lorach

OXFORD UNIV PRESS2022

Epidural electrical stimulation of the cervical dorsal roots restores voluntary upper limb control in paralyzed monkeys

Tomislav Milekovic, Giuseppe Schiavone, Florian Dylan Fallegger, Stéphanie Lacour, Grégoire Courtine, Quentin Barraud, Katia Galan, Jocelyne Bloch, Nicholas David James

Regaining arm control is a top priority for people with paralysis. Unfortunately, the complexity of the neural mechanisms underlying arm control has limited the effectiveness of neurotechnology approaches. Here, we exploited the neural function of survivin ...

NATURE PORTFOLIO2022

Principles of gait encoding in the subthalamic nucleus of people with Parkinson's disease

Grégoire Courtine, Eduardo Martin Moraud, Jocelyne Bloch, Jimmy James Ravier, Carmina Andrea Galvez Solano

Disruption of subthalamic nucleus dynamics in Parkinson's disease leads to impairments during walking. Here, we aimed to uncover the principles through which the subthalamic nucleus encodes functional and dysfunctional walking in people with Parkinson's di ...

AMER ASSOC ADVANCEMENT SCIENCE2022

Activity-dependent spinal cord neuromodulation rapidly restores trunk and leg motor functions after complete paralysis

Dimitri Nestor Alice Van De Ville, Léonie Asboth, Nawal Noëlle Kinany, Salif Axel Komi, Silvestro Micera, Grégoire Courtine, Miroslav Caban, Quentin Barraud, Marco Capogrosso, Fabien Bertrand Paul Wagner, Robin Jonathan Demesmaeker, Andreas Rowald, Nathan Antoine Greiner, Jocelyne Bloch, Sergio Daniel Hernandez, Laura Ann McCracken, Henri Charles Alexandre Lorach, Edeny Baaklini, Jimmy James Ravier, Carmina Andrea Galvez Solano

Epidural electrical stimulation (EES) targeting the dorsal roots of lumbosacral segments restores walking in people with spinal cord injury (SCI). However, EES is delivered with multielectrode paddle leads that were originally designed to target the dorsal ...

NATURE PORTFOLIO2022

The neurons that restore walking after paralysis

Léonie Asboth, Salif Axel Komi, Stéphanie Lacour, Grégoire Courtine, Quentin Barraud, Laetitia Danielle Philippine Baud, Katia Galan, Fabien Bertrand Paul Wagner, Robin Jonathan Demesmaeker, Andreas Rowald, Newton Cho, Jocelyne Bloch, Claudia Kathe, Nicholas David James, Jordan Squair, Matthieu Pierre Gautier, Kyungjin Kim, Thomas Haynes Hutson, Steven Lee Ceto

A spinal cord injury interrupts pathways from the brain and brainstem that project to the lumbar spinal cord, leading to paralysis. Here we show that spatiotemporal epidural electrical stimulation (EES) of the lumbar spinal cord(1-3) applied during neurore ...

NATURE PORTFOLIO2022

Hyperpolarized C-13-glucose magnetic resonance highlights reduced aerobic glycolysis in vivo in infiltrative glioblastoma

Arnaud Comment, Bernard Lanz, Rolf Gruetter, Cristina Ramona Cudalbu, Mor-Miri Mishkovsky, Jocelyne Bloch

Glioblastoma (GBM) is the most aggressive brain tumor type in adults. GBM is heterogeneous, with a compact core lesion surrounded by an invasive tumor front. This front is highly relevant for tumor recurrence but is generally non-detectable using standard ...

Nature Research2021

Neuroprosthetic baroreflex controls haemodynamics after spinal cord injury

Jérôme Gandar, Giuseppe Schiavone, Nicolas Vachicouras, Florian Dylan Fallegger, Salif Axel Komi, Stéphanie Lacour, Arnaud Bichat, Grégoire Courtine, Quentin Barraud, Kay Alexander Bartholdi, Eduardo Martin Moraud, Marco Capogrosso, Mark Andrew Anderson, Fabien Bertrand Paul Wagner, Robin Jonathan Demesmaeker, Ileana Ozana Jelescu, Andreas Rowald, Newton Cho, Jocelyne Bloch, Claudia Kathe, Nicholas David James, Jordan Squair, Laura Ann McCracken, Matthieu Pierre Gautier, Loïs Thomas Romain Mahe, Jimmy James Ravier

Spinal cord injury (SCI) induces haemodynamic instability that threatens survival(1-3), impairs neurological recovery(4,5), increases the risk of cardiovascular disease(6,7), and reduces quality of life(8,9). Haemodynamic instability in this context is due ...

NATURE RESEARCH2021

Soft, Implantable Bioelectronic Interfaces for Translational Research

Sébastien Jiguet, Giuseppe Schiavone, Nicolas Vachicouras, Florian Dylan Fallegger, Stéphanie Lacour, Grégoire Courtine, Marco Capogrosso, Evgenia Vladimirova Roussinova, Ivan Furfaro, Andreas Rowald, Beatrice Barra, Simon Borgognon, Jocelyne Bloch, Xiaoyang Kang, Ismael Seanez Gonzalez

The convergence of materials science, electronics, and biology, namely bioelectronic interfaces, leads novel and precise communication with biological tissue, particularly with the nervous system. However, the translation of lab‐based innovation toward cli ...

Wiley2020

Cortical Projection From the Premotor or Primary Motor Cortex to the Subthalamic Nucleus in Intact and Parkinsonian Adult Macaque Monkeys: A Pilot Tracing Study

Simon Pierre Jean Badoud, Simon Borgognon, Jocelyne Bloch

Besides the main cortical inputs to the basal ganglia, via the corticostriatal projection, there is another input via the corticosubthalamic projection (CSTP), terminating in the subthalamic nucleus (STN). The present study investigated and compared the CS ...

FRONTIERS MEDIA SA2020

Automatic clustering of spinal reflexes evoked by epidural electrical stimulation of the cervical spinal cord in non-human primates

Giuseppe Schiavone, Stéphanie Lacour, Grégoire Courtine, Marco Capogrosso, Sara Conti, Beatrice Barra, Katie Zhi Zhuang, Jocelyne Bloch

Epidural electrical stimulation of the spinal cord elicits motor responses by recruiting large sensory afferents in the posterior roots. Divergence of excitatory inputs provided by these fibers generates a variety of shapes, latencies and amplitudes in the ...

2019

System for selective spatiotemporal stimulation of the spinal cord

Silvestro Micera, Grégoire Courtine, Nikolaus Wenger, Marco Capogrosso, Jocelyne Bloch

The present disclosure refers to systems for electrical neurostimulation of a spinal cord of a subject in need of nervous system function support. In one example, a system comprises a signal processing device configured to receive signals from the subject ...

2019

Hypertonic Lactate to Improve Cerebral Perfusion and Glucose Availability After Acute Brain Injury

Pierre Magistretti, Jocelyne Bloch

Objectives: Lactate promotes cerebral blood flow and is an efficient substrate for the brain, particularly at times of glucose shortage. Hypertonic lactate is neuroprotective after experimental brain injury; however, human data are limited. ...

LIPPINCOTT WILLIAMS & WILKINS2018

Configuration of electrical spinal cord stimulation through real-time processing of gait kinematics

Tomislav Milekovic, Jérôme Gandar, Grégoire Courtine, Nikolaus Wenger, Eduardo Martin Moraud, Pavel Musienko, Marco Capogrosso, Natalia Pavlova, Fabien Bertrand Paul Wagner, Polina Shkorbatova, Jocelyne Bloch

Epidural electrical stimulation (EES) of the spinal cord and real-time processing of gait kinematics are powerful methods for the study of locomotion and the improvement of motor control after injury or in neurological disorders. Here, we describe equipmen ...

2018

Selective Recruitment of Arm Motoneurons in Nonhuman Primates Using Epidural Electrical Stimulation of the Cervical Spinal Cord

Giuseppe Schiavone, Camille Roux, Stéphanie Lacour, Grégoire Courtine, Marco Capogrosso, Beatrice Barra, Jocelyne Bloch

Recovery of reaching and grasping ability is the priority for people with cervical spinal cord injury (SCI). Epidural electrical stimulation (EES) has shown promising results in improving motor control after SCI in various animal models and in humans. Nota ...

2018

Electrical spinal cord stimulation must preserve proprioception to enable locomotion in humans with spinal cord injury

Camille Georgette Marie Le Goff-Mignardot, Silvestro Micera, Grégoire Courtine, Emanuele Formento, Marco Capogrosso, Jean-Baptiste Mignardot, Fabien Bertrand Paul Wagner, Andreas Rowald, Karen Minassian, Jocelyne Bloch

Epidural electrical stimulation (EES) of the spinal cord restores locomotion in animal models of spinal cord injury but is less effective in humans. Here we hypothesized that this interspecies discrepancy is due to interference between EES and propriocepti ...

2018

Long-term functionality of a soft electrode array for epidural spinal cord stimulation in a minipig model

Giuseppe Schiavone, Nicolas Vachicouras, Florian Dylan Fallegger, Stéphanie Lacour, Grégoire Courtine, Marco Capogrosso, Fabien Bertrand Paul Wagner, Beatrice Barra, Jocelyne Bloch, Xiaoyang Kang

Long-term biointegration of man-made neural interfaces is influenced by the mechanical properties of the implant materials. Substantial experimental work currently aims at replacing conventional hard implant materials with soft alternatives that can favour ...

IEEE2018

Differential contributions of subthalamic beta rhythms and 1/f broadband activity to motor symptoms in Parkinson’s disease

Ricardo Andres Chavarriaga Lozano, José del Rocio Millán Ruiz, Stéphanie Martin, Robert Leeb, Inaki Asier Iturrate Gil, Aleksander Sobolewski, Jocelyne Bloch

Excessive beta oscillatory activity in the subthalamic nucleus (STN) is linked to Parkinson’s Disease (PD) motor symptoms. However, previous works have been inconsistent regarding the functional role of beta activity in untreated Parkinsonian states, quest ...

2018

Targeted neurotechnology restores walking in humans with spinal cord injury

Vincent Delattre, Camille Georgette Marie Le Goff-Mignardot, Salif Axel Komi, Elvira Pirondini, Roman Heimgartner, Grégoire Courtine, Miroslav Caban, Joachim von Zitzewitz, Marco Capogrosso, Jean-Baptiste Mignardot, Fabien Bertrand Paul Wagner, Robin Jonathan Demesmaeker, Andreas Rowald, Karen Minassian, Esra Neufeld, Jocelyne Bloch, Ismael Seanez Gonzalez, Hendrik Lambert, Anne Marie Lucienne Watrin, Perrine Seguin, Laura Ann McCracken, Molywan Vat, Edoardo Paoles

2018

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