Alexandre Louis André Persat

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Bacterial gut commensals experience a biologically and physically complex mucosal environment. While many chemical factors mediate the composition and structure of these microbial communities, less is known about the role of mechanics. Here, we demonstrate ...

The opportunistic pathogen Pseudomonas aeruginosa explores surfaces using twitching motility powered by retractile extracellu-lar filaments called type IV pili (T4P). Single cells twitch by sequen-tial T4P extension, attachment, and retraction. How single ...

In vitro models mimicking in-patient conditions have the potential to yield exciting opportunities for antibiotic research and revitalize future antibiotic discovery and development. ...

Alexandre Louis André Persat

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Fluid flow structures gut microbiota biofilm communities by distributing public goods

Mechanotaxis directs Pseudomonas aeruginosa twitching motility

Revitalizing antibiotic discovery and development through in vitro modelling of in-patient conditions

Bacterial Mechanosensing with Type IV Pili