Publications by Simone Astori | EPFL Graph Search

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Neuronal excitation imposes a high demand of ATP in neurons. Most of the ATP derives primarily from pyruvate-mediated oxidative phosphorylation, a process that relies on import of pyruvate into mitochondria occuring exclusively via the mitochondrial pyruva ...

The stress response facilitates survival through adaptation and is intimately related to cognitive processes. The Morris water maze task probes spatial learning and memory in rodents and glucocorticoids (i.e. corticosterone (CORT) in rats) have been sugges ...

Background: Chronic anxiety is common, disabling, and often refractory to current therapies. Mounting evidence implicates mitochondrial abnormalities in anxiety-related phenotypes. Urolithin A (UA), a gut microbiota-derived metabolite known to enhance mito ...

Background: Understanding why only a subset of trauma-exposed individuals develop posttraumatic stress disorder is critical for advancing clinical strategies. A few behavioral (deficits in fear extinction) and biological (blunted glucocorticoid levels, sma ...

Obesity is frequently associated with impairments in the social domain, and stress at puberty can lead to long-lasting changes in visceral fat deposition and in social behaviors. However, whether stress-induced changes in adipose tissue can affect fat-to-b ...

Individuals frequently differ in their behavioral and cognitive responses to stress. However, whether motivation is differently affected by acute stress in different individuals remains to be established. By exploiting natural variation in trait anxiety in ...

Silva et al. reveal distinct circuits for the extinction of remote fear memories, with the thalamic nucleus reuniens and its outputs to the basolateral amygdala taking center stage. Fear and trauma generate some of the longest-lived memories. Despite the c ...

Corticotropin-releasing hormone (CRH) is a peptide associated with stress and anxiety that acts as a potent modulator throughout the nervous system. The thalamic reticular nucleus (TRN) displays high expression of the CRH receptor 1 (CRHR1), but whether CR ...

Memories are encoded by sparse populations of neurons but how such sparsity arises remains largely unknown. We found that a neuron’s eligibility to be recruited into the memory trace depends on its epigenetic state prior to encoding. Principal neurons in t ...

Simone Astori

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Paradoxical neuronal hyperexcitability in a mouse model of mitochondrial pyruvate import deficiency

Constitutive differences in glucocorticoid responsiveness are related to divergent spatial information processing abilities

Urolithin A abolishes high anxiety and rescues the associated mitochondria-related transcriptomic signatures and synaptic function

Blunted Glucocorticoid Responsiveness to Stress Causes Behavioral and Biological Alterations That Lead to Posttraumatic Stress Disorder Vulnerability

eNAMPT actions through nucleus accumbens NAD + /SIRT1 link increased adiposity with sociability deficits programmed by peripuberty stress

Opposite effects of stress on effortful motivation in high and low anxiety are mediated by CRHR1 in the VTA

A thalamo-amygdalar circuit underlying the extinction of remote fear memories

Corticotropin-releasing hormone modulates NREM sleep consolidation through the thalamic reticular nucleus

Chromatin plasticity predetermines neuronal eligibility for memory trace formation

The brain’s go-getter circuit: Anterior cingulate cortex to nucleus accumbens and its disruption by stress