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Bruno Emanuel Ferreira De Sousa Correia

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Related publications (178)

Page 5 of 9

The physiological landscape and specificity of antibody repertoires are consolidated by multiple immunizations

Bruno Emanuel Ferreira De Sousa Correia, Fabian Sesterhenn

Diverse antibody repertoires spanning multiple lymphoid organs (i.e., bone marrow, spleen, lymph nodes) form the foundation of protective humoral immunity. Changes in their composition across lymphoid organs are a consequence of B-cell selection and migrat ...

2024

Material migration and fuel retention studies during the JET carbon divertor campaigns

Olivier Sauter, Martinus Adela Maria Gijs, Jonathan Graves, Ambrogio Fasoli, Stefano Coda, Basil Duval, Henri Weisen, Richard Pitts, Yves Martin, Javier García Hernández, Duccio Testa, Miguel Fernández Ruiz, Nicola Vianello, Robin Humphry-Baker, Sun Hee Kim, Federico Nespoli, Patrick Blanchard, Alessandro Pau, David Pfefferlé, Davide Galassi, Jonathan Marc Philippe Faustin, Cristian Sommariva, Hamish William Patten, Samuel Lanthaler, Jan Horacek, Yann Camenen, Bruno Emanuel Ferreira De Sousa Correia, José Pedro Rebelo Ferreira Marques, Mikhail Maslov, Marco Wischmeier, Dalziel Joseph Wilson, Liang Yao, Daniel Scott Alessi, Arnout Lodewijk M Beckers, Ana Francisca Leal Silva Soares, Jonnathan Cesar Hidalgo Acosta, Antonio José Pereira de Figueiredo, Partha Dutta, Pierre-Thomas Paul Brun, Pedro Camilo de Oliveira e Silva, Alberto Hernando de Castro, Julio Rodriguez, Vlad Trifa, Li Shuai, Rebecca Hill

The first divertor was installed in the JET machine between 1992 and 1994 and was operated with carbon tiles and then beryllium tiles in 1994-5. Post-mortem studies after these first experiments demonstrated that most of the impurities deposited in the div ...

2019

Scaffolding protein functional sites using deep learning

Bruno Emanuel Ferreira De Sousa Correia, Wayne Yang Wen Wei, Karla Montserrat Castro Gilabert

The binding and catalytic functions of proteins are generally mediated by a small number of functional residues held in place by the overall protein structure. Here, we describe deep learning approaches for scaffolding such functional sites without needing ...

American Association for the Advancement of Science2022

Heat flux analysis of Type-I ELM impact on a sloped, protruding surface in the JET bulk tungsten divertor

Tungsten (W) melting due to transient power loads, for example those delivered by edge localised modes (ELMs), is a major concern for next step fusion devices. A series of experiments has been performed on JET to investigate the dynamics of Type-I ELM-indu ...

Elsevier2018

Activation of ITER materials in JET: nuclear characterisation experiments for the long-term irradiation station

This paper details progress in experimental characterisation work at JET for the long-term irradiation station, conducted as part of a project to perform activation experiments using ITER materials. The aim is to take advantage of the significant 14 MeV ne ...

IOP Publishing Ltd2018

Identification of BeO and BeOxDy in melted zones of the JET Be limiter tiles: Raman study using comparison with laboratory samples

Beryllium oxide (BeO) and deuteroxide (BeOxDy) have been found on the melted zone of a beryllium tile extracted from the upper dump plate of JET-ILW (2011-2012 campaign). Results have been obtained using Raman microscopy, which is sensitive to both the che ...

Elsevier2018

Targeting protein-ligand neosurfaces with a generalizable deep learning tool

Joseph Giuseppe Schmidt, Maddalena Elia, Yangyang Miao, Evgenia Elizarova, Bruno Emanuel Ferreira De Sousa Correia, Sebastian Maerkl, Luc Reymond, Philippe Schwaller, Pablo Gainza Cirauqui, Sandrine Madeleine Suzanne Georgeon, Leo Scheller, Anthony Marchand, Martin Pacesa, Arne Schneuing, Stephen Michael Buckley, Rebecca Manuela Neeser

Molecular recognition events between proteins drive biological processes in living systems1. However, higher levels of mechanistic regulation have emerged, in which protein-protein interactions are conditioned to small molecules2, 3, 4-5. Despite recent ad ...

NATURE PORTFOLIO2025

Structure-based immunogen design - leading the way to the new age of precision vaccines

Bruno Emanuel Ferreira De Sousa Correia, Jaume Bonet Martinez, Fabian Sesterhenn

Vaccines have been one of the most successful interventions in global health. However, traditional vaccine development has proven insufficient to deal with pathogens that elude the immune system through highly variable and non-functional epitopes. Emerging ...

2018

Computational design of anti-CRISPR proteins with improved inhibition potency

Wei Sun, Bruno Emanuel Ferreira De Sousa Correia, Sandrine Madeleine Suzanne Georgeon, Stéphane Rosset, Zander Harteveld, Andreas Scheck

Anti-CRISPR (Acr) proteins are powerful tools to control CRISPR-Cas technologies. However, the available Acr repertoire is limited to naturally occurring variants. Here, we applied structure-based design on AcrIIC1, a broad-spectrum CRISPR-Cas9 inhibitor, ...

NATURE PUBLISHING GROUP2020

3D non-linear MHD simulation of the MHD response and density increase as a result of shattered pellet injection

The MHD response and the penetration of a deuterium shattered pellet into a JET plasma is investigated via the non-linear reduced MHD code JOREK with the neutral gas shielding (NGS) ablation model. The dominant MHD destabilizing mechanism by the injection ...

IOP Publishing Ltd2018

Rational Design of Chemically Controlled Antibodies and Protein Therapeutics

Bruno Emanuel Ferreira De Sousa Correia, Li Tang, Pablo Gainza Cirauqui, Sandrine Madeleine Suzanne Georgeon, Stéphane Rosset, Leo Scheller, Anthony Marchand, Sailan Shui, Lucia Bonati

Protein-based therapeutics, such as monoclonal antibodies and cytokines, are important therapies for various pathophysiological conditions such as oncology, autoimmune disorders, and viral infections. However, the wide application of such protein therapeut ...

2023

Scaling of the geodesic acoustic mode amplitude on JET

This work aims at establishing the parameter space for the existence of geodesic acoustic modes (GAMs) on JET as well as investigating their driving and damping mechanisms predicted by different theoretical models. This was achieved using an experimental d ...

2018

First observation of the depolarization of Thomson scattering radiation by a fusion plasma

We report the first experimental observation of the depolarization of the Thomson scattering (TS) radiation, a relativistic effect expected to occur in very high T-e plasmas and never observed so far in a fusion machine. A set of unused optical fibers in t ...

IOP Publishing Ltd2018

Effects of nitrogen seeding on core ion thermal transport in JET ILW L-mode plasmas

A set of experiments was carried out in JET ILW (Joint European Torus with ITER-Like Wall) L-mode plasmas in order to study the effects of light impurities on core ion thermal transport. N was puffed into some discharges and its profile was measured by act ...

IOP Publishing Ltd2018

First mirror test in JET for ITER: Complete overview after three ILW campaigns

Olivier Sauter, Martinus Adela Maria Gijs, Ambrogio Fasoli, Stefano Coda, Basil Duval, Henri Weisen, Richard Pitts, Yves Martin, Javier García Hernández, Duccio Testa, Miguel Fernández Ruiz, Nicola Vianello, Robin Humphry-Baker, Sun Hee Kim, Patrick Blanchard, Alessandro Pau, Davide Galassi, Cristian Sommariva, Jan Horacek, Yann Camenen, Bruno Emanuel Ferreira De Sousa Correia, Jonathan Graves, José Pedro Rebelo Ferreira Marques, Mikhail Maslov, Marco Wischmeier, Dalziel Joseph Wilson, Liang Yao, Daniel Scott Alessi, Arnout Lodewijk M Beckers, Ana Francisca Leal Silva Soares, Jonnathan Cesar Hidalgo Acosta, Antonio José Pereira de Figueiredo, Partha Dutta, Pierre-Thomas Paul Brun, Pedro Camilo de Oliveira e Silva, Alberto Hernando de Castro, Julio Rodriguez, Vlad Trifa, Li Shuai, Rebecca Hill, Federico Nespoli, Hamish William Patten, Samuel Lanthaler, David Pfefferlé, Jonathan Marc Philippe Faustin

The First Mirror Test for ITER has been carried out in JET with mirrors exposed during: (i) the third ILW campaign (ILW-3, 2015-2016, 23.33 h plasma) and (ii) all three campaigns, i.e. ILW-1 to ILW-3: 2011-2016, 63,52 h in total. All mirrors from main cham ...

Elsevier2019

Computational design of soluble and functional membrane protein analogues

Christian Schellhaas, Lars Jeremy Dornfeld, Nicolas Manuel Goldbach, Bruno Emanuel Ferreira De Sousa Correia, Sandrine Madeleine Suzanne Georgeon, Stéphane Rosset, Casper Alexander Goverde, Martin Pacesa

De novo design of complex protein folds using solely computational means remains a substantial challenge1. Here we use a robust deep learning pipeline to design complex folds and soluble analogues of integral membrane proteins. Unique membrane topologies, ...

2024

Voices of biotech research

Bruno Emanuel Ferreira De Sousa Correia, Jacob Thomas Thorn

NATURE RESEARCH2021

Assessing and enhancing foldability in designed proteins

Bruno Emanuel Ferreira De Sousa Correia, Stéphane Rosset, Che Yang

Recent advances in protein-design methodology have led to a dramatic increase in reliability and scale. With these advances, dozens and even thousands of designed proteins are automatically generated and screened. Nevertheless, the success rate, particular ...

WILEY2022

Boosting subdominant neutralizing antibody responses with a computationally designed epitope-focused immunogen

Bruno Emanuel Ferreira De Sousa Correia, Jaume Bonet Martinez, Pablo Gainza Cirauqui, Fabian Sesterhenn, Stéphane Rosset, Che Yang, Patricia Corthésy Henrioud, Sabrina Susan Vollers

Throughout the last several decades, vaccination has been key to prevent and eradicate infectious diseases. However, many pathogens (e.g., respiratory syncytial virus [RSV], influenza, dengue, and others) have resisted vaccine development efforts, largely ...

2019

Proof of principle for epitope-focused vaccine design

Bruno Emanuel Ferreira De Sousa Correia

Wiley-Blackwell2015