Bruno Emanuel Ferreira De Sousa Correia

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Operation of the JET tokamak with beryllium and tungsten ITER-like wall provides unique opportunity for detailed studies on dust generation: quantity, morphology, location, etc. The programme carried out in response to ITER needs for safety assessment comp ...

In the preparation for the Deuterium-Tritium campaign, JET will operate with a tritium plasma. The T + T reaction consists of two notable channels: (1) T + T -> He-4 + 2n, (2) T + T -> He-5 + n -> He-4 + 2n. The reaction channel (1) is the reaction with th ...

A theoretical model for isotopologues of beryllium monohydride, BeH, BeD and BeT, A (2)Pi to X (2)Sigma(+) visible and X (2)Sigma(+) to X (2)Sigma(+) infrared rovibronic spectra is presented. The MARVEL procedure is used to compute empirical rovibronic ene ...

Diverse antibody repertoires spanning multiple lymphoid organs (i.e., bone marrow, spleen, lymph nodes) form the foundation of protective humoral immunity. Changes in their composition across lymphoid organs are a consequence of B-cell selection and migrat ...

The first divertor was installed in the JET machine between 1992 and 1994 and was operated with carbon tiles and then beryllium tiles in 1994-5. Post-mortem studies after these first experiments demonstrated that most of the impurities deposited in the div ...

Tungsten (W) melting due to transient power loads, for example those delivered by edge localised modes (ELMs), is a major concern for next step fusion devices. A series of experiments has been performed on JET to investigate the dynamics of Type-I ELM-indu ...

This paper details progress in experimental characterisation work at JET for the long-term irradiation station, conducted as part of a project to perform activation experiments using ITER materials. The aim is to take advantage of the significant 14 MeV ne ...

Beryllium oxide (BeO) and deuteroxide (BeOxDy) have been found on the melted zone of a beryllium tile extracted from the upper dump plate of JET-ILW (2011-2012 campaign). Results have been obtained using Raman microscopy, which is sensitive to both the che ...

Molecular recognition events between proteins drive biological processes in living systems1. However, higher levels of mechanistic regulation have emerged, in which protein-protein interactions are conditioned to small molecules2, 3, 4-5. Despite recent ad ...

Anti-CRISPR (Acr) proteins are powerful tools to control CRISPR-Cas technologies. However, the available Acr repertoire is limited to naturally occurring variants. Here, we applied structure-based design on AcrIIC1, a broad-spectrum CRISPR-Cas9 inhibitor, ...

Vaccines have been one of the most successful interventions in global health. However, traditional vaccine development has proven insufficient to deal with pathogens that elude the immune system through highly variable and non-functional epitopes. Emerging ...

Protein-based therapeutics, such as monoclonal antibodies and cytokines, are important therapies for various pathophysiological conditions such as oncology, autoimmune disorders, and viral infections. However, the wide application of such protein therapeut ...

This work aims at establishing the parameter space for the existence of geodesic acoustic modes (GAMs) on JET as well as investigating their driving and damping mechanisms predicted by different theoretical models. This was achieved using an experimental d ...

The MHD response and the penetration of a deuterium shattered pellet into a JET plasma is investigated via the non-linear reduced MHD code JOREK with the neutral gas shielding (NGS) ablation model. The dominant MHD destabilizing mechanism by the injection ...

We report the first experimental observation of the depolarization of the Thomson scattering (TS) radiation, a relativistic effect expected to occur in very high T-e plasmas and never observed so far in a fusion machine. A set of unused optical fibers in t ...

A set of experiments was carried out in JET ILW (Joint European Torus with ITER-Like Wall) L-mode plasmas in order to study the effects of light impurities on core ion thermal transport. N was puffed into some discharges and its profile was measured by act ...

The First Mirror Test for ITER has been carried out in JET with mirrors exposed during: (i) the third ILW campaign (ILW-3, 2015-2016, 23.33 h plasma) and (ii) all three campaigns, i.e. ILW-1 to ILW-3: 2011-2016, 63,52 h in total. All mirrors from main cham ...

De novo design of complex protein folds using solely computational means remains a substantial challenge1. Here we use a robust deep learning pipeline to design complex folds and soluble analogues of integral membrane proteins. Unique membrane topologies, ...

Recent advances in protein-design methodology have led to a dramatic increase in reliability and scale. With these advances, dozens and even thousands of designed proteins are automatically generated and screened. Nevertheless, the success rate, particular ...

Throughout the last several decades, vaccination has been key to prevent and eradicate infectious diseases. However, many pathogens (e.g., respiratory syncytial virus [RSV], influenza, dengue, and others) have resisted vaccine development efforts, largely ...

Bruno Emanuel Ferreira De Sousa Correia

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Dust generation in tokamaks: Overview of beryllium and tungsten dust characterisation in JET with the ITER-like wall

Activation material selection for multiple foil activation detectors in JET TT campaign

Synthetic spectra of BeH, BeD and BeT for emission modeling in JET plasmas

The physiological landscape and specificity of antibody repertoires are consolidated by multiple immunizations

Material migration and fuel retention studies during the JET carbon divertor campaigns

Heat flux analysis of Type-I ELM impact on a sloped, protruding surface in the JET bulk tungsten divertor

Activation of ITER materials in JET: nuclear characterisation experiments for the long-term irradiation station

Identification of BeO and BeOxDy in melted zones of the JET Be limiter tiles: Raman study using comparison with laboratory samples

Targeting protein-ligand neosurfaces with a generalizable deep learning tool

Computational design of anti-CRISPR proteins with improved inhibition potency

Structure-based immunogen design - leading the way to the new age of precision vaccines

Rational Design of Chemically Controlled Antibodies and Protein Therapeutics

Scaling of the geodesic acoustic mode amplitude on JET

3D non-linear MHD simulation of the MHD response and density increase as a result of shattered pellet injection

First observation of the depolarization of Thomson scattering radiation by a fusion plasma

Effects of nitrogen seeding on core ion thermal transport in JET ILW L-mode plasmas

First mirror test in JET for ITER: Complete overview after three ILW campaigns

Computational design of soluble and functional membrane protein analogues

Assessing and enhancing foldability in designed proteins

Boosting subdominant neutralizing antibody responses with a computationally designed epitope-focused immunogen