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David Lyndon Emsley

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Related publications (178)

Molecular bases of D76N beta-2 microglobulin pathologic aggregation propensity

David Lyndon Emsley

Springer2017

Determining the Surface Structure of Silicated Alumina Catalysts via Isotopic Enrichment and Dynamic Nuclear Polarization Surface-Enhanced NMR Spectroscopy

David Lyndon Emsley, Brennan James Walder, Jasmine Viger-Gravel

Isotopic enrichment of Si-29 and DNP-enhanced NMR spectroscopy are combined to determine the detailed surface structure of a silicated alumina catalyst. The significant sensitivity enhancement provided by DNP is vital to the acquisition of multinuclear and ...

American Chemical Society2017

Transportable hyperpolarized metabolites

Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet, Jonas Milani, Basile Vuichoud, David Benjamin Roger Antoine Gajan, Xiao Ji, David Lyndon Emsley, Aaron James Rossini

Nuclear spin hyperpolarization of C-13-labelled metabolites by dissolution dynamic nuclear polarization can enhance the NMR signals of metabolites by several orders of magnitude, which has enabled in vivo metabolic imaging by MRI. However, because of the s ...

Nature Publishing Group2017

The structure and binding mode of citrate in the stabilization of gold nanoparticles

David Benjamin Roger Antoine Gajan, David Lyndon Emsley, Jasmine Viger-Gravel

Elucidating the binding mode of carboxylate-containing ligands to gold nanoparticles (AuNPs) is crucial to understand their stabilizing role. A detailed picture of the three-dimensional structure and coordination modes of citrate, acetate, succinate and gl ...

Nature Publishing Group2017

The Atomic-Level Structure of Cementitious Calcium Silicate Hydrate

Paul Bowen, Karen Scrivener, Aslam Kunhi Mohamed, Abhishek Kumar, David Lyndon Emsley, Aaron James Rossini, Albert Hofstetter, Bhuvanesh Srinivasan, Brennan James Walder

Efforts to tune the bulk physical properties of concrete are hindered by a lack of knowledge related to the atomic-level structure and growth of calcium silicate hydrate phases, which form about 50-60% by volume of cement paste. Here we describe the first ...

2017

Solvent suppression in DNP enhanced solid state NMR

David Lyndon Emsley, Aaron James Rossini, Jayasubba Reddy Yarava

We show how DNP enhanced solid-state NMR spectra can be dramatically simplified by suppression of solvent signals. This is achieved by (i) exploiting the paramagnetic relaxation enhancement of solvent signals relative to materials substrates, or (ii) by us ...

Academic Press Inc - Elsevier Science2017

Frozen Acrylamide Gels as Dynamic Nuclear Polarization Matrices

David Benjamin Roger Antoine Gajan, David Lyndon Emsley, Jasmine Viger-Gravel, Pierrick Berruyer

Aqueous acrylamide gels can be used to provide dynamic nuclear polarization (DNP) NMR signal enhancements of around 200 at 9.4 T and 100 K. The enhancements are shown to increase with crosslinker concentration and low concentrations of the AMUPol biradical ...

Wiley-VCH Verlag GmbH2017

Structured and porous materials particularly suitable as polarizing agents in dissolution dynamic nuclear polarization

Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet, David Benjamin Roger Antoine Gajan, David Lyndon Emsley, David Baudouin

The present invention concerns materials consisting in a porous and structured network, this network being at least in part formed by Si atoms, or Si atoms and metal atoms, linked to each other by oxy bridges, comprising organic molecules which include at ...

2016

Transportable long-lived hyperpolarized samples

Geoffrey Bodenhausen, Sami Jannin, David Lyndon Emsley

A method for the preparation of a hyperpolarized solution of molecules comprises the steps: 1) suspending or coating of a micro-particulate matrix, which is comprising or consisting of the molecules, with a glass-forming solution or suspension comprising a ...

2016

Structure of viral nucleocapsid by solid-state NMR at 100 kHz magic-angle spinning

David Lyndon Emsley

Wiley-Blackwell2016

Rational design of dinitroxide biradicals for efficient cross-effect dynamic nuclear polarization

Dominik Józef Kubicki, David Lyndon Emsley, Aaron James Rossini

A series of 37 dinitroxide biradicals have been prepared and their performance studied as polarizing agents in cross-effect DNP NMR experiments at 9.4 T and 100 K in 1,1,2,2-tetrachloroethane (TCE). We observe that in this regime the DNP performance is str ...

2016

Microwave-gated dynamic nuclear polarization

Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet, Xiao Ji, Arthur César Pinon, David Lyndon Emsley, Mathieu Baudin

Dissolution dynamic nuclear polarization (D-DNP) has become a method of choice to enhance signals in nuclear magnetic resonance (NMR). Recently, we have proposed to combine cross-polarization (CP) with D-DNP to provide high polarization P(C-13) in short bu ...

Royal Society of Chemistry2016

Polymorphs of Theophylline Characterized by DNP Enhanced Solid-State NMR

David Benjamin Roger Antoine Gajan, Arthur César Pinon, David Lyndon Emsley, Aaron James Rossini

We show how dynamic nuclear polarization (DNP) enhanced solid-state NMR spectroscopy can be used to characterize polymorphs and solvates of organic solids. We applied DNP to three polymorphs and one hydrated form of the asthma drug molecule theophylline. F ...

American Chemical Society2015

Sensitivity and resolution of proton detected spectra of a deuterated protein at 40 and 60 kHz magic-angle-spinning

David Lyndon Emsley

The use of small rotors capable of very fast magic-angle spinning (MAS) in conjunction with proton dilution by perdeuteration and partial reprotonation at exchangeable sites has enabled the acquisition of resolved, proton detected, solid-state NMR spectra ...

Springer Verlag2015

Direct observation of hierarchical protein dynamics

David Lyndon Emsley

One of the fundamental challenges of physical biology is to understand the relationship between protein dynamics and function. At physiological temperatures, functional motions arise from the complex interplay of thermal motions of proteins and their envir ...

American Association for the Advancement of Science2015

Hybrid polarizing solids for pure hyperpolarized liquids through dissolution dynamic nuclear polarization

Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet, Jonas Milani, Basile Vuichoud, David Benjamin Roger Antoine Gajan, David Lyndon Emsley

Hyperpolarization of substrates for magnetic resonance spectroscopy (MRS) and imaging (MRI) by dissolution dynamic nuclear polarization (D-DNP) usually involves saturating the ESR transitions of polarizing agents (PAs; e.g., persistent radicals embedded in ...

National Academy of Sciences2014

Amplifying Dynamic Nuclear Polarization of Frozen Solutions by Incorporating Dielectric Particles

Dominik Józef Kubicki, David Lyndon Emsley, Aaron James Rossini

There is currently great interest in understanding the limits on NMR signal enhancements provided by dynamic nuclear polarization (DNP), and in particular if the theoretical maximum enhancements can be achieved. We show that over a 2-fold improvement in cr ...

American Chemical Society2014

Dynamic nuclear polarization of quadrupolar nuclei using cross polarization from protons: surface-enhanced aluminium-27 NMR

Geoffrey Bodenhausen, Pascal Miéville, Marc Anthony Caporini, Diego Carnevale, David Benjamin Roger Antoine Gajan, David Lyndon Emsley, Aaron James Rossini, Moreno Lelli

The surface of gamma-alumina nanoparticles can be characterized by dynamic nuclear polarization (DNP) surface-enhanced NMR of Al-27. DNP is combined with cross-polarization and MQ-MAS to determine local symmetries of Al-27 sites at the surface. ...

Royal Society of Chemistry2012

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