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Tzu-En Lin

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Related publications (21)

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Reversible solid-oxide cell stack based power-to-x-to-power systems: Comparison of thermodynamic performance

François Maréchal, Jan Van Herle, Ligang Wang, Tzu-En Lin, Philippe Aubin, Maria del Mar Perez Fortes, Yumeng Zhang

The increasing penetration of variable renewable energies poses new challenges for grid management. The economic feasibility of grid-balancing plants may be limited by low annual operating hours if they work either only for power generation or only for pow ...

2020

Electrochemical Imaging of Cells and Tissues

Hubert Girault, Andreas Stephan Lesch, Tzu-En Lin

The technological and experimental progress in electrochemical imaging of biological specimens is discussed with a view on potential applications for skin cancer diagnostics, reproductive medicine and microbial testing. The electrochemical analysis of sing ...

2018

A Review of Evaluation, Optimization and Synthesis of Energy Systems: Methodology and Application to Thermal Power Plants

François Maréchal, Shivom Sharma, Ligang Wang, Alberto Mian, Tzu-En Lin

To reach optimal/better conceptual designs of energy systems, key design variables should be optimized/adapted with system layouts, which may contribute significantly to system improvement. Layout improvement can be proposed by combining system analysis wi ...

2018

Power-to-fuels via solid-oxide electrolyzer: Operating window and techno-economics

François Maréchal, Jan Van Herle, Stefan Diethelm, Ligang Wang, Tzu-En Lin

Power-to-fuel systems via solid-oxide electrolysis are promising for storing excess renewable electricity by efficient electrolysis of steam (or co-electrolysis of steam and CO2) into hydrogen (or syngas), which can be further converted into synthetic fuel ...

2019

Power-to-methane via co-electrolysis of H2O and CO2: The effects of pressurized operation and internal methanation

François Maréchal, Jan Van Herle, Stefan Diethelm, Ligang Wang, Tzu-En Lin

This paper presents a model-based investigation to handle the fundamental issues for the design of co-electrolysis based power-to-methane at the levels of both the stack and system: the role of CO2 in co-electrolysis, the benefits of employing pressurized ...

2019

Tape-Stripping Electrochemical Detection of Melanoma

Hubert Girault, Andreas Stephan Lesch, Horst Pick, Tzu-En Lin, Yingdi Zhu, Sorour Darvishi

A noninvasive electrochemical melanoma detection approach based on using adhesive tapes for collecting and fixing cells from a suspicious skin area and transferring the cells into a scanning electrochemical microscope (SECM) is presented. The adhesive laye ...

AMER CHEMICAL SOC2019

Electrostatic spray ionization from 384-well microtiter plates for mass spectrometry analysis based enzyme assay and drug metabolism screening

Hubert Girault, Liang Qiao, Tzu-En Lin, Elena Tobolkina, Xiaoqin Zhong

We have realized the direct ionization of samples from wells of microtiter plates under atmospheric conditions for mass spectrometry analysis without any liquid delivery system or any additional interface. The microtiter plate is a commercially available 3 ...

American Chemical Society2017

Soft Electrochemical Probes for Mapping the Distribution of Biomarkers and Injected Nanomaterials in Animal and Human Tissues

Hubert Girault, Andreas Stephan Lesch, Horst Pick, Tzu-En Lin, Yu Lu

Monitoring biomarkers and injected theranostic nanomaterials in tissues and organs plays a pivotal role in numerous medical applications ranging from cancer diagnostics to drug delivery. Scanning electrochemical microscopy has been demonstrated as a powerf ...

Wiley-Blackwell2017

MALDI Detection of Exosomes: A Potential Tool for Cancer Studies

Hubert Girault, Horst Pick, Natalia Gasilova, Tzu-En Lin, Yingdi Zhu

Matrix-assisted laser desorption ionization time-of-flight mass spectrometry is used to detect intact whole exosomes, yielding exosomal fingerprints within minutes. This rapid exosome detection approach is proposed as a potential tool for cancer studies. M ...

2019

Rapid Noninvasive Skin Monitoring by Surface Mass Recording and Data Learning

Hubert Girault, Andreas Stephan Lesch, Horst Pick, Natalia Gasilova, Tzu-En Lin, Milica Jovic, Yingdi Zhu

Skin problems are often overlooked due to a lack of robust and patient-friendly monitoring tools. Herein, we report a rapid, noninvasive, and high-throughput analytical chemical methodology, aiming at real-time monitoring of skin conditions and early detec ...

2021

A Review: Electrochemical Biosensors for Oral Cancer

Hubert Girault, Ligang Wang, Tzu-En Lin, Sorour Darvishi

Oral cancer poses a serious threat worldwide owing to its soaring case-fatality rate and its metastatic characteristics of spreading to the other parts of the body. Despite the recent breakthroughs in biomedical sciences, the detection of oral cancer at an ...

2020

In situ detection of multitarget impurities on contact lens by electrochemical scanning probe

Fang Liu, Tzu-En Lin, Yingdi Zhu

Identifying multitarget impurities on contact lenses is challenging because traditional methods such as polymerase chain reaction cannot be used on the unknown target. Other sampling methods often require expensive antibodies or dyes. Therefore, this resea ...

ELSEVIER SCIENCE SA2023

Soft probes for bio-electrochemical imaging

Tzu-En Lin

The aim of bioimaging is to visualize properties and processes of living objects or biological samples and extracts image-related information for revealing important physical structures or map the distribution of specific biomolecules in tissues for clinic ...

EPFL2017

Skin cell analysis

Hubert Girault, Andreas Stephan Lesch, Horst Pick, Milica Jovic, Tzu-En Lin, Yingdi Zhu

The present invention describes an adhesive tape stripping transfer method for quick and non-invasive diagnosis of skin diseases by MALDI-TOF mass spectrometry analysis. Cells from the epidermis layer of a suspicious skin area of a patient are collected us ...

2020

Monitoring Tyrosinase Expression in Non-metastatic and Metastatic Melanoma Tissues by Scanning Electrochemical Microscopy

Hubert Girault, Fernando Cortes Salazar, Andreas Stephan Lesch, Horst Pick, Alexandra Bondarenko, Tzu-En Lin

Although tremendous progress has been made in the diagnosis of melanoma, the identification of different stages of malignancy in a reliable way remains challenging. Current strategies rely on optical monitoring of the concentration and spatial distribution ...

Wiley-Blackwell2016

Multiple scanning electrochemical microscopy mapping of tyrosinase in micro-contact printed fruit samples on polyvinylidene fluoride membrane

Hubert Girault, Andreas Stephan Lesch, Liang Qiao, Fernando Cortes Salazar, Alexandra Bondarenko, Tzu-En Lin

Herein, we introduce three orthogonal and compatible methods for detecting tyrosinase, a key factor in fruit browning and skin disorders, with high spatial resolution by means of scanning electrochemical microscopy (SECM). All methods are performed subsequ ...

Elsevier2015

Mapping the antioxidant activity of apple peels with soft probe scanning electrochemical microscopy

Hubert Girault, Andreas Stephan Lesch, Tzu-En Lin

We present a non-invasive electrochemical strategy for mapping the antioxidant (AO) activity of apple peels, which counterbalances oxidative stress caused by various external effectors. Soft carbon microelectrodes were used for soft probe scanning electroc ...

Elsevier Science Sa2017

Microfluidic Probes for Scanning Electrochemical Microscopy

Hubert Girault, Andreas Stephan Lesch, Fernando Cortes Salazar, Alexandra Bondarenko, Tzu-En Lin

This chapter discusses the soft microfluidic scanning electrochemical microscopy (SECM) probes represent a versatile tool for supporting various investigations ranging from the electrochemical characterization of different surfaces to the local perturbatio ...

Wiley2018

Fixation and Permeabilization Approaches for Scanning Electrochemical Microscopy of Living Cells

Hubert Girault, Andreas Stephan Lesch, Horst Pick, Fernando Cortes Salazar, Alexandra Bondarenko, Tzu-En Lin, Petar Stupar

Scanning electrochemical microscopy (SECM) has been widely used for the electrochemical imaging of dynamic topographical and metabolic changes in alive adherent mammalian cells. However, extracting intracellular information by SECM is challenging, since it ...

American Chemical Society2016

Untersuchung der Tyrosinase-Expression in nicht-metastatischen und metastatischen Melanomgeweben durch elektrochemische Rastersondenmikroskopie

Hubert Girault, Horst Pick, Fernando Cortes Salazar, Andreas Stephan Lesch, Alexandra Bondarenko, Tzu-En Lin

Trotz des enormen Fortschritts, der bei der Diagnose von Melanomen erzielt wurde, bleibt die zuverlässige Erkennung der verschiedenen Malignomstadien eine Herausforderung. Derzeitige Strategien setzen auf die optische Erfassung der Konzentration und räumli ...

Wiley-Blackwell2016