Publications by Eduardo Martin Moraud

Related publications (26)

Advantages of soft subdural implants for the delivery of electrochemical neuromodulation therapies to the spinal cord

Stéphanie Lacour, Grégoire Courtine, Marco Capogrosso, Pavel Musienko, Eduardo Martin Moraud, Ivan Rusev Minev, Nikolaus Wenger, Jérôme Gandar, Nathan Antoine Greiner

Objective. We recently developed soft neural interfaces enabling the delivery of electrical and chemical stimulation to the spinal cord. These stimulations restored locomotion in animal models of paralysis. Soft interfaces can be placed either below or abo ...

2018

Exercise and gait/movement analyses in treatment and diagnosis of Parkinson's Disease

Eduardo Martin Moraud

Cardinal motor symptoms in Parkinson's disease (PD) include bradykinesia, rest tremor and/or rigidity. This symptomatology can additionally encompass abnormal gait, balance and postural patterns at advanced stages of the disease. Besides pharmacological an ...

2023

Inhaling xenon ameliorates l -dopa-induced dyskinesia in experimental parkinsonism

Grégoire Courtine, Eduardo Martin Moraud, Tomislav Milekovic, Shiqi Sun

Parkinson's disease motor symptoms are treated with levodopa, but long‐term treatment leads to disabling dyskinesia. Altered synaptic transmission and maladaptive plasticity of corticostriatal glutamatergic projections play a critical role in the pathophys ...

2018

Neuroprosthetic baroreflex controls haemodynamics after spinal cord injury

Stéphanie Lacour, Grégoire Courtine, Marco Capogrosso, Jocelyne Bloch, Giuseppe Schiavone, Florian Dylan Fallegger, Nicolas Vachicouras, Quentin Barraud, Jordan Squair, Ileana Ozana Jelescu, Eduardo Martin Moraud, Fabien Bertrand Paul Wagner, Robin Jonathan Demesmaeker, Claudia Kathe, Matthieu Pierre Gautier, Mark Andrew Anderson, Newton Cho, Nicholas David James, Salif Axel Komi, Jimmy James Ravier, Jérôme Gandar, Andreas Rowald, Kay Alexander Bartholdi, Charlotte Marie Jacques Moerman, Achilleas Laskaratos, Laura Ann McCracken, Loïs Thomas Romain Mahe, Arnaud Bichat

Spinal cord injury (SCI) induces haemodynamic instability that threatens survival(1-3), impairs neurological recovery(4,5), increases the risk of cardiovascular disease(6,7), and reduces quality of life(8,9). Haemodynamic instability in this context is due ...

NATURE RESEARCH2021

A brain-spine interface alleviating gait deficits after spinal cord injury in primates

Silvestro Micera, Grégoire Courtine, Jocelyne Bloch, Marco Capogrosso, Quentin Barraud, Eduardo Martin Moraud, Fabien Bertrand Paul Wagner, Jérôme Gandar, Jean-Baptiste Mignardot, Tomislav Milekovic, David Allenson Borton, Elodie Rey

Spinal cord injury disrupts the communication between the brain and the spinal circuits that orchestrate movement. To bypass the lesion, brain-computer interfaces(1-3) have directly linked cortical activity to electrical stimulation of muscles, and have th ...

Nature Publishing Group2016

Spatiotemporal neuromodulation therapies engaging muscle synergies improve motor control after spinal cord injury

Silvestro Micera, Stéphanie Lacour, Grégoire Courtine, Jocelyne Bloch, Marco Capogrosso, Quentin Barraud, Eduardo Martin Moraud, Ivan Rusev Minev, Léonie Asboth, Jérôme Gandar, Nikolaus Wenger, Arthur Edouard Hirsch, Pavel Musienko, Laetitia Danielle Philippine Baud, Natalia Pavlova, Julie Kreider

Electrical neuromodulation of lumbar segments improves motor control after spinal cord injury in animal models and humans. However, the physiological principles underlying the effect of this intervention remain poorly understood, which has limited the ther ...

Nature Publishing Group2016

Toward a Unified Gait Freeze Index: a Standardized Benchmark for Clinical and Regulatory Evaluations

Paula Sanchez Lopez, Eduardo Martin Moraud

Freezing of Gait (FOG) is a disabling motor symptom that affects a majority of individuals with advanced Parkinson's disease, severely limiting mobility, independence, and quality of life. Automatic methods for detecting FOG using the freeze index (FI) hav ...

FRONTIERS MEDIA SA2025

Corticospinal neuroprostheses to restore locomotion after spinal cord injury

Silvestro Micera, José del Rocio Millán Ruiz, Stéphanie Lacour, Grégoire Courtine, Eduardo Martin Moraud, Ivan Rusev Minev, Nikolaus Wenger, Pavel Musienko, Marco Bonizzato, Janine Beauparlant, David Allenson Borton

In this conceptual review, we highlight our strategy for, and progress in the development of corticospinal neuroprostheses for restoring locomotor functions and promoting neural repair after thoracic spinal cord injury in experimental animal models. We spe ...

Elsevier2014

Configuration of electrical spinal cord stimulation through real-time processing of gait kinematics

Grégoire Courtine, Jocelyne Bloch, Marco Capogrosso, Pavel Musienko, Eduardo Martin Moraud, Nikolaus Wenger, Fabien Bertrand Paul Wagner, Tomislav Milekovic, Jérôme Gandar, Natalia Pavlova

Epidural electrical stimulation (EES) of the spinal cord and real-time processing of gait kinematics are powerful methods for the study of locomotion and the improvement of motor control after injury or in neurological disorders. Here, we describe equipmen ...

Nature Publishing Group2018

Rehabilitative Soft Exoskeleton for Rodents

Silvestro Micera, Grégoire Courtine, Jamie Paik, Eduardo Martin Moraud, Sophie Marie Marthe Wurth, Laetitia Danielle Philippine Baud, Joachim von Zitzewitz, Juan Manuel Florez Marin

Robotic exoskeletons provide programmable, consistent and controllable active therapeutic assistance to patients with neurological disorders. Here we introduce a prototype and preliminary experimental evaluation of a rehabilitative gait exoskeleton that en ...

Institute of Electrical and Electronics Engineers2016

Adaptive, personalized closed-loop therapy for Parkinson's disease: biochemical, neurophysiological, and wearable sensing systems

Eduardo Martin Moraud

Introduction Motor complication management is one of the main unmet needs in Parkinson's disease patients. Areas covered Among the most promising emerging approaches for handling motor complications in Parkinson's disease, adaptive deep brain stimulation s ...

TAYLOR & FRANCIS LTD2021

System to deliver adaptive epidural and/or subdural electrical spinal cord stimulation to facilitate and restore locomotion after a neuromotor impairment

Silvestro Micera, Grégoire Courtine, Eduardo Martin Moraud, Nikolaus Wenger, Marco Bonizzato

The present disclosure provides a closed-loop system for real-time control of epidural and/or subdural electrical stimulation comprising means for applying to a subject neuromodulation with adjustable stimulation parameters, said means being operatively co ...

2018

Closed-loop neuromodulation of spinal sensorimotor circuits controls refined locomotion after complete spinal cord injury

Silvestro Micera, Grégoire Courtine, Stanisa Raspopovic, Eduardo Martin Moraud, Nikolaus Wenger, Marco Bonizzato, Pavel Musienko, John Francis Di Giovanna

Neuromodulation of spinal sensorimotor circuits improves motor control in animal models and humans with spinal cord injury. With common neuromodulation devices, electrical stimulation parameters are tuned manually and remain constant during movement. We de ...

American Association for the Advancement of Science2014

A real-time platform for studying the modulatory capacity of epidural stimulation after spinal cord injury

Silvestro Micera, Grégoire Courtine, Eduardo Martin Moraud, Jérôme Gandar, Nikolaus Wenger, Pavel Musienko

Epidural electrical stimulation (EES) showed promises to improve standing and walking after neurological disorders. To date, EES has been delivered continuously, although time-dependent stimulations would likely be more efficient to activate specific subse ...

Ieee2013

Neuroprosthetic technologies to augment the impact of neurorehabilitation after spinal cord injury

Silvestro Micera, Grégoire Courtine, Jocelyne Bloch, Eduardo Martin Moraud, Joachim von Zitzewitz, Nicolas Francis Fumeaux, Marco Capogrosso, Fabien Bertrand Paul Wagner, Jean-Baptiste Mignardot

Spinal cord injury leads to a range of disabilities, including limitations in locomotor activity, that seriously diminish the patients’ autonomy and quality of life. Electrochemical neuromodulation therapies, robot-assisted rehabilitation and willpower-bas ...

2015

Biomaterials. Electronic dura mater for long-term multimodal neural interfaces

Silvestro Micera, Stéphanie Lacour, Grégoire Courtine, Marco Capogrosso, Nicolas Vachicouras, Quentin Barraud, Eduardo Martin Moraud, Ivan Rusev Minev, Léonie Asboth, Tomislav Milekovic, Nikolaus Wenger, Arthur Edouard Hirsch, Pavel Musienko, Jérôme Gandar, Natalia Pavlova

The mechanical mismatch between soft neural tissues and stiff neural implants hinders the long-term performance of implantable neuroprostheses. Here, we designed and fabricated soft neural implants with the shape and elasticity of dura mater, the protectiv ...

American Association for the Advancement of Science2015

Controlling Clinical States Governed by Different Temporal Dynamics With Closed-Loop Deep Brain Stimulation: A Principled Framework

Eduardo Martin Moraud

Closed-loop strategies for deep brain stimulation (DBS) are paving the way for improving the efficacy of existing neuromodulation therapies across neurological disorders. Unlike continuous DBS, closed-loop DBS approaches (cl-DBS) optimize the delivery of s ...

FRONTIERS MEDIA SA2021

Neuromodulation/neurostimulation system for mitigating locomotor deficits of parkinson's disease, spinal cord injury (sci), stroke and/or other neurological disorders

Grégoire Courtine, Jocelyne Bloch, Jordan Squair, Eduardo Martin Moraud, Léonie Asboth, Robin Jonathan Demesmaeker, Tomislav Milekovic, Newton Cho

The present invention relates to a combined neuromodulation and/or neurostimulation system (10) for mitigating locomotor deficits of/or neuronal disorders, especially Parkinson's disease, said system (10) comprising: - at least one Deep Brain Stimulation ( ...

2023

Two-phase calibration of a neuroprosthetic system

Grégoire Courtine, Marco Capogrosso, Eduardo Martin Moraud, Fabien Bertrand Paul Wagner, Tomislav Milekovic, Jérôme Gandar

Methods and systems are provided for triggering electrical stimulation of a spinal cord during execution of a motor event. In one example, a method comprises monitoring motor cortex activity while execution of a desired motor movement is attempted during a ...

2018

Actigraphy Enables Home Screening of Rapid Eye Movement Behavior Disorder in Parkinson's Disease

Eduardo Martin Moraud

Objectives Rapid eye movement sleep behavior disorder (RBD) is a potentially harmful, often overlooked sleep disorder affecting up to 70% of Parkinson's disease patients. Current diagnosis relies on nocturnal video-polysomnography, which is an expensive an ...

WILEY2022