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Grégoire Courtine

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Related publications (146)

Page 6 of 8

Neuromodulation/neurostimulation system for controlling a respiratory function

Grégoire Courtine, Jocelyne Bloch, Léonie Asboth, Robin Jonathan Demesmaeker, Vincent Delattre, Miroslav Caban, Nicolas Hankov

The present invention relates to a neuromodulation/neurostimulation system for supporting and/or controlling a function of t he respiratory system of a patient, said function comprising a plurality of phases each involving one or more muscles. The system c ...

2024

Single cell atlas of spinal cord injury in mice reveals a pro-regenerative signature in spinocerebellar neurons

Grégoire Courtine, Jordan Squair, Claudia Kathe

After spinal cord injury, tissue distal to the lesion contains undamaged cells that could support or augment recovery. Targeting these cells requires a clearer understanding of their injury responses and capacity for repair. Here, we use single nucleus RNA ...

Nature Portfolio2022

Electronic Dura Mater Meddling in the Central Nervous System

Stéphanie Lacour, Grégoire Courtine, Jocelyne Bloch

IMPORTANCE A growing number of neurologic treatments rely on neural implants capable of delivering electrical and chemical stimulation to targeted regions of the central nervous system for extended periods. OBJECTIVE To assess the potential of a novel clas ...

Amer Medical Assoc2017

Electrical spinal cord stimulation must preserve proprioception to enable locomotion in humans with spinal cord injury

Silvestro Micera, Grégoire Courtine, Jocelyne Bloch, Marco Capogrosso, Fabien Bertrand Paul Wagner, Karen Minassian, Emanuele Formento, Jean-Baptiste Mignardot, Andreas Rowald, Camille Georgette Marie Le Goff-Mignardot

Epidural electrical stimulation (EES) of the spinal cord restores locomotion in animal models of spinal cord injury but is less effective in humans. Here we hypothesized that this interspecies discrepancy is due to interference between EES and propriocepti ...

2018

Brain–machine interface: closer to therapeutic reality?

Silvestro Micera, José del Rocio Millán Ruiz, Grégoire Courtine, John Francis Di Giovanna

Elsevier Science Inc2013

Natural and targeted circuit reorganization after spinal cord injury

Grégoire Courtine, Jocelyne Bloch, Quentin Barraud, Jordan Squair, Claudia Kathe, Matthieu Pierre Gautier, Mark Andrew Anderson, Thomas Haynes Hutson

The authors summarize changes in circuits after spinal cord injury and current strategies to target these circuits in order to improve recovery, but also advocate for new concepts of reorganizing circuits informed by multi-omic single-cell atlases. ...

NATURE PORTFOLIO2022

System for planning and/or providing neuromodulation

Grégoire Courtine, Marco Capogrosso, Fabien Bertrand Paul Wagner, Vincent Delattre, Karen Minassian

The present invention relates to systems and methods for planning and/or providing neuromodulation One example system includesa stimulation related basic data storage module for storing stimulation related basic data,a stimulation related response data sto ...

2021

Best practices for differential accessibility analysis in single-cell epigenomics

Grégoire Courtine, Jordan Squair, Michael Alexander Skinnider

Differential accessibility (DA) analysis of single-cell epigenomics data enables the discovery of regulatory programs that establish cell type identity and steer responses to physiological and pathophysiological perturbations. While many statistical method ...

Nature Research2024

Optogenetic Interrogation of Circuits Following Neurotrauma

Grégoire Courtine, Steven Lee Ceto

Biological and engineering strategies for neural repair and recovery from neurotrauma continue to emerge at a rapid pace. Until recently, studies of the impact of neurotrauma and repair strategies on the reorganization of the central nervous system have fo ...

FRONTIERS MEDIA SA2021

Low-Dimensional Motor Cortex Dynamics Preserve Kinematics Information During Unconstrained Locomotion in Nonhuman Primates (vol

Grégoire Courtine, David Allenson Borton

FRONTIERS MEDIA SA2020

Domains Of Neural Control Of Walking In Human Spinal Cord Injury

Grégoire Courtine

Mary Ann Liebert, Inc2014

Engineering spinal cord repair

Grégoire Courtine, Jordan Squair, Matthieu Pierre Gautier, Mark Andrew Anderson, Michael V. Sofroniew

Neurological damage caused by spinal cord injury in humans has been observed for over three thousand years and impacts the lives of several hundred thousand people worldwide. Despite this prevalence and its associated consequences, there is no treatment to ...

CURRENT BIOLOGY LTD2021

Ultralong, complexly structured micro- and nanoscale metallic glasses and fibers

Grégoire Courtine, Fabien Sorin, Wei Yan, Inès Richard

The present invention and its embodiments propose a simple, unique, and scalable method for producing extremely long, highly uniform, and well-ordered micro- and nanoscale metallic glasses via thermal drawing the method comprising at least the steps of pre ...

2020

A spinal neuroprosthesis against locomotor deficits in Parkinson's disease

Grégoire Courtine, Jocelyne Bloch

Edp Sciences S A2024

A system for providing neuromodulation, especially neurostimulation

Grégoire Courtine, Marco Capogrosso, Katie Zhi Zhuang

A system (10) for providing neuromodulation, especially neurostimulation, comprising - at least one neuromodulator (12) for neuromodulation of the cervical spinal cord, - at least one dorsal neuromodulation array (14) for providing neuromodulation to the c ...

2020

Apparatus comprising a support system for a user and its operation in a gravity-assist mode

Grégoire Courtine, Jean-Baptiste Mignardot, Joachim von Zitzewitz, Camille Georgette Marie Le Goff-Mignardot

The present application relates to devices and systems for rehabilitation of the locomotor system, for example limbs. In particular, the present application discloses an apparatus, more in particular a robotic platform capable of optimizing gravity-depende ...

2018

A Computational Model for Epidural Electrical Stimulation of Spinal Sensorimotor Circuits

Silvestro Micera, Grégoire Courtine, Marco Capogrosso, Stanisa Raspopovic, Nikolaus Wenger, Pavel Musienko, Janine Beauparlant

Epidural electrical stimulation (EES) of lumbosacral segments can restore a range of movements after spinal cord injury. However, the mechanisms and neural structures through which EES facilitates movement execution remain unclear. Here, we designed a comp ...

Society for Neuroscience2013

Automatic clustering of spinal reflexes evoked by epidural electrical stimulation of the cervical spinal cord in non-human primates

Katie Zhi Zhuang, Stéphanie Lacour, Grégoire Courtine, Marco Capogrosso, Jocelyne Bloch, Giuseppe Schiavone

Epidural electrical stimulation of the spinal cord elicits motor responses by recruiting large sensory afferents in the posterior roots. Divergence of excitatory inputs provided by these fibers generates a variety of shapes, latencies and amplitudes in the ...

2019

System and method for control of autonomic function

Grégoire Courtine, Jordan Squair

A system (10) for neuromodulation and/or neurostimulation, for the treatment of a mammal, at least comprising: - at least one control unit (12) configured and arranged to provide stimulation data; - at least one stimulation unit (14) configured and arrange ...

2020

Defining Ecological Strategies in Neuroprosthetics

Grégoire Courtine, Jocelyne Bloch

Neurological disorders disrupt the equilibrium within the brain and spinal cord ecosystems. Ecology reuses, recycles, and reduces to help maintain the balance across ecosystems. Likewise, neuroprosthetics can help the brain help itself with ecoprosthetic d ...

Elsevier2015