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Grégoire Courtine

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Related publications (146)

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Non-invasive spinal cord electrical stimulation for arm and hand function in chronic tetraplegia: a safety and efficacy trial

Grégoire Courtine, Jordan Squair

Cervical spinal cord injury (SCI) leads to permanent impairment of arm and hand functions. Here we conducted a prospective, single-arm, multicenter, open-label, non-significant risk trial that evaluated the safety and efficacy of ARCEX Therapy to improve a ...

Nature Portfolio2024

Required growth facilitators propel axon regeneration across complete spinal cord injury

Grégoire Courtine, Mark Andrew Anderson, Nicholas David James, Cheng Wang, Sabry Leonardo Barlatey, Michael V. Sofroniew

Transected axons fail to regrow across anatomically complete spinal cord injuries (SCI) in adults. Diverse molecules can partially facilitate or attenuate axon growth during development or after injury1,2,3, but efficient reversal of this regrowth failure ...

2018

Hypothalamic deep brain stimulation augments walking after spinal cord injury

Nadia Bérard, Michael Hodara, Kristina Sveistyte, Anna Leonhartsberger, Grégoire Courtine, Jocelyne Bloch, Quentin Barraud, Léonie Asboth, Robin Jonathan Demesmaeker, Claudia Kathe, Matthieu Pierre Gautier, Katia Galan, Mark Andrew Anderson, Newton Cho, Nicholas David James, Thomas Haynes Hutson, Jimmy James Ravier, Laetitia Danielle Philippine Baud, Kay Alexander Bartholdi, Achilleas Laskaratos, Camille Claire Varescon, Nicolas Hankov, Inssia Dewany, Nadine Intering, Viviana Aureli, Frédéric Norbert Merlos

A spinal cord injury (SCI) disrupts the neuronal projections from the brain to the region of the spinal cord that produces walking, leading to various degrees of paralysis. Here, we aimed to identify brain regions that steer the recovery of walking after i ...

NATURE PORTFOLIO2024

Activity-dependent spinal cord neuromodulation rapidly restores trunk and leg motor functions after complete paralysis

Dimitri Nestor Alice Van De Ville, Silvestro Micera, Grégoire Courtine, Marco Capogrosso, Jocelyne Bloch, Quentin Barraud, Nawal Noëlle Kinany, Léonie Asboth, Fabien Bertrand Paul Wagner, Robin Jonathan Demesmaeker, Salif Axel Komi, Jimmy James Ravier, Henri Charles Alexandre Lorach, Andreas Rowald, Miroslav Caban, Nathan Antoine Greiner, Carmina Andrea Galvez Solano, Sergio Daniel Hernandez, Laura Ann McCracken, Edeny Baaklini

Epidural electrical stimulation (EES) targeting the dorsal roots of lumbosacral segments restores walking in people with spinal cord injury (SCI). However, EES is delivered with multielectrode paddle leads that were originally designed to target the dorsal ...

NATURE PORTFOLIO2022

System for selective spatiotemporal stimulation of the spinal cord

Silvestro Micera, Grégoire Courtine, Marco Capogrosso, Jocelyne Bloch, Nikolaus Wenger

The present disclosure refers to systems for electrical neurostimulation of a spinal cord of a subject in need of nervous system function support. In one example, a system comprises a signal processing device configured to receive signals from the subject ...

2019

Neuromodulation/neurostimulation system for restoring a motor function and facilitating neurological recovery

Grégoire Courtine, Jocelyne Bloch, Henri Charles Alexandre Lorach

The present invention relates to a neuromodulation/neurostimulation system (100) for restoring a motor function of the upper and/or lower limbs and facilitating neurological recovery in a patient (P) with spinal cord injury (SCI) and/or other neurological ...

2024

Elezanumab, a human anti-RGMa monoclonal antibody, promotes neuroprotection, neuroplasticity, and neurorecovery following a thoracic hemicompression spinal cord injury in non-human primates

Grégoire Courtine, Quentin Barraud

Spinal cord injury (SCI) is a devastating condition characterized by loss of function, secondary to damaged spinal neurons, disrupted axonal connections, and myelin loss. Spontaneous recovery is limited, and there are no approved pharmaceutical treatments ...

2021

Methods for Functional Assessment After C7 Spinal Cord Hemisection in the Rhesus Monkey

Grégoire Courtine

Background. Reliable outcome measures are essential for preclinical modeling of spinal cord injury (SCI) in primates. Measures need to be sensitive to both increases and decreases in function in order to demonstrate potential positive or negative effects o ...

2012

Engagement of the Rat Hindlimb Motor Cortex across Natural Locomotor Behaviors

Silvestro Micera, Grégoire Courtine, Lucia Florinda Friedli Wittler, Janine Beauparlant, Jacopo Rigosa, Julie Kreider

Contrary to cats and primates, cortical contribution to hindlimb locomotor movements is not critical in rats. However, the importance of the motor cortex to regain locomotion after neurological disorders in rats suggests that cortical engagement in hindlim ...

Soc Neuroscience2016

Spatiotemporal neuromodulation therapies engaging muscle synergies improve motor control after spinal cord injury

Silvestro Micera, Stéphanie Lacour, Grégoire Courtine, Jocelyne Bloch, Marco Capogrosso, Quentin Barraud, Eduardo Martin Moraud, Ivan Rusev Minev, Léonie Asboth, Jérôme Gandar, Nikolaus Wenger, Arthur Edouard Hirsch, Pavel Musienko, Laetitia Danielle Philippine Baud, Natalia Pavlova, Julie Kreider

Electrical neuromodulation of lumbar segments improves motor control after spinal cord injury in animal models and humans. However, the physiological principles underlying the effect of this intervention remain poorly understood, which has limited the ther ...

Nature Publishing Group2016

A neurorobotic platform for locomotor prosthetic development in rats and mice

Grégoire Courtine, Joachim von Zitzewitz, Léonie Asboth, Nicolas Francis Fumeaux, Laetitia Danielle Philippine Baud

Objectives. We aimed to develop a robotic interface capable of providing finely-tuned, multidirectional trunk assistance adjusted in real-time during unconstrained locomotion in rats and mice. Approach. We interfaced a large-scale robotic structure actuate ...

Institute of Physics2016

The neurons that restore walking after paralysis

Ruijia Wang, Stéphanie Lacour, Grégoire Courtine, Jocelyne Bloch, Quentin Barraud, Jordan Squair, Léonie Asboth, Fabien Bertrand Paul Wagner, Robin Jonathan Demesmaeker, Claudia Kathe, Matthieu Pierre Gautier, Kyungjin Kim, Katia Galan, Newton Cho, Nicholas David James, Thomas Haynes Hutson, Salif Axel Komi, Laetitia Danielle Philippine Baud, Andreas Rowald, Steven Lee Ceto, Nicola Aldo Regazzi

A spinal cord injury interrupts pathways from the brain and brainstem that project to the lumbar spinal cord, leading to paralysis. Here we show that spatiotemporal epidural electrical stimulation (EES) of the lumbar spinal cord(1-3) applied during neurore ...

NATURE PORTFOLIO2022

A Computational Framework for the Design of Spinal Neuroprostheses

Silvestro Micera, Grégoire Courtine, Jocelyne Bloch, Marco Capogrosso

Severe Spinal Cord Injury (SCI) alters the communication between supra-spinal centers and the sensorimotor networks coordinating limb movements, which are usually located below the injury. Epidural electrical stimulation of lumbar segments has shown the ab ...

Springer International Publishing Ag2017

A neuromechanics solution for adjustable robot compliance and accuracy

Auke Ijspeert, Grégoire Courtine, Alice Julie Bruel

Robots have to adjust their motor behavior to changing environments and variable task requirements to successfully operate in the real world and physically interact with humans. Thus, robotics strives to enable a broad spectrum of adjustable motor behavior ...

AMER ASSOC ADVANCEMENT SCIENCE2025

Intrafascicular peripheral nerve stimulation produces fine functional hand movements in primates

Ilaria Scarpato, Silvestro Micera, Grégoire Courtine, Sophie Marie Marthe Wurth, Simon Borgognon, Marion Aimée Geneviève Badi-Dubois, Evgenia Vladimirova Roussinova

Restoring dexterous hand control is critical for people with paralysis. Approaches based on surface or intramuscular stimulation provide limited finger control, generate insufficient force to recover functional movements, and require numerous electrodes. H ...

AMER ASSOC ADVANCEMENT SCIENCE2021

Animal Models of Neurologic Disorders: A Nonhuman Primate Model of Spinal Cord Injury

Grégoire Courtine

Primates are an important and unique animal resource. We have developed a nonhuman primate model of spinal cord injury (SCI) to expand our knowledge of normal primate motor function, to assess the impact of disease and injury on sensory and motor function, ...

2012

Configuration of electrical spinal cord stimulation through real-time processing of gait kinematics

Grégoire Courtine, Jocelyne Bloch, Marco Capogrosso, Pavel Musienko, Eduardo Martin Moraud, Nikolaus Wenger, Fabien Bertrand Paul Wagner, Tomislav Milekovic, Jérôme Gandar, Natalia Pavlova

Epidural electrical stimulation (EES) of the spinal cord and real-time processing of gait kinematics are powerful methods for the study of locomotion and the improvement of motor control after injury or in neurological disorders. Here, we describe equipmen ...

Nature Publishing Group2018

Versatile robotic interface to evaluate, enable and train locomotion and balance after neuromotor disorders

Grégoire Courtine, Pavel Musienko, Lucia Florinda Friedli Wittler

Central nervous system (CNS) disorders distinctly impair locomotor pattern generation and balance, but technical limitations prevent independent assessment and rehabilitation of these subfunctions. Here we introduce a versatile robotic interface to evaluat ...

Nature Publishing Group2012

A multidirectional gravity-assist algorithm that enhances locomotor control in patients with stroke or spinal cord injury

Auke Ijspeert, Grégoire Courtine, Jocelyne Bloch, Marco Capogrosso, Joachim von Zitzewitz, Nicolas Francis Fumeaux, Jean-Baptiste Mignardot, Jessica Lanini, Selin Anil

Gait recovery after neurological disorders requires remastering the interplay between body mechanics and gravitational forces. Despite the importance of gravity-dependent gait interactions and active participation for promoting this learning, these essenti ...

Amer Assoc Advancement Science2017

Structured nanoscale metallic glass fibres with extreme aspect ratios

Stéphanie Lacour, Grégoire Courtine, Fabien Sorin, Vasiliki Tileli, Giuseppe Schiavone, Wei Yan, Jordan Squair, Yunpeng Qu, Dang Tùng Nguyen, Reinis Ignatans, Güven Kurtuldu, Inès Richard, Nicholas David James

Micro- and nanoscale metallic glasses offer exciting opportunities for both fundamental research and applications in healthcare, micro-engineering, optics and electronics. The scientific and technological challenges associated with the fabrication and util ...

Nature Publishing Group2020