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Maroun Bou Sleiman

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Related publications (31)

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The Drosophila gut response to infection : a systems approach

Maroun Bou Sleiman

Genetic, physiological, and biochemical studies have successfully ascribed functions to genes in diverse processes. However, the majority of our knowledge in biology is qualitative in nature and is usually based on classical screens, where large effects on ...

EPFL2016

The Gene-Regulatory Footprint of Aging Highlights Conserved Central Regulators

Johan Auwerx, Richardus Houtkooper, Maroun Bou Sleiman, Xu Wang, Pooja Jha

Many genes and pathways have been linked to aging, yet our understanding of underlying molecular mechanisms is still lacking. Here, we measure changes in the transcriptome, histone modifications, and DNA methylome in three metabolic tissues of adult and ag ...

2020

Article Multi-omics analysis identifies essential regulators of mitochondrial stress response in two wild-type C. elegans strains

Johan Auwerx, Maroun Bou Sleiman, Kevin Sebastiaan Hof, Yang Li, Gaby El Alam, Wen Gao, Amélia Lalou

The mitochondrial unfolded protein response (UPRmt) is a promising pharmacological target for aging and age-related diseases. However, the integrative analysis of the impact of UPRmt activation on different signaling layers in animals with different geneti ...

CELL PRESS2022

Systems genetics of metabolic health in the BXD mouse genetic reference population

Jonathan Allen Sulc, Johan Auwerx, Maroun Bou Sleiman, Giorgia Benegiamo, Wen Gao, Jean-David Horacio Morel, Xiaoxu Li, Alessia De Masi, Amélia Lalou, Jia Liu, Johanne Gracia Anne Poisson

Susceptibility to metabolic syndrome (MetS) is dependent on genetics, environment, and gene-by-environment interactions, rendering the study of underlying mechanisms challenging. The majority of experiments in model organisms do not incorporate genetic var ...

2024

ACMSD INHIBITION REDUCES HEPATIC INFLAMMATION AND FIBROSIS IN A MURINE THERMONEUTRALITY MODEL OF NASH

Johan Auwerx, Richardus Houtkooper, Krisztian Homicsko, Maroun Bou Sleiman, Xiaoxu Li, Sandra Rodriguez Lopez, Jia Liu, Keno Strotjohann

Lippincott Williams & Wilkins2023

The Genetic Background Shapes Disease Susceptibility And Reveals A Specific Role For Mitochondrial Dysfunction In The Progression From Nafld To Nash

Johan Auwerx, Alexis Maximilien Bachmann, Maroun Bou Sleiman, Giacomo Vincenzo Giorgio Von Alvensleben, Giorgia Benegiamo, Jean-David Horacio Morel, Sandra Rodriguez Lopez, Jia Liu

WILEY2022

The genetic background shapes the susceptibility to mitochondrial dysfunction and NASH progression

Johan Auwerx, Alexis Maximilien Bachmann, Maroun Bou Sleiman, Giacomo Vincenzo Giorgio Von Alvensleben, Giorgia Benegiamo, Jean-David Horacio Morel, Ludger Jan Elzuë Goeminne, Sandra Rodriguez Lopez

Mice from different genetic backgrounds have widely diverse responses to the same metabolic challenges. Only PWK/PhJ mice show significant mitochondrial dysfunction and progression to fibrotic NASH that resembles human NASH. The PWK/PhJ strain is a novel N ...

ROCKEFELLER UNIV PRESS2023

Mitochondrial matrix protein LETMD1 maintains thermogenic capacity of brown adipose tissue in male mice

Johan Auwerx, Maroun Bou Sleiman, Jun Yong Kim, Xiaoxu Li

Brown adipose tissue (BAT) has abundant mitochondria with the unique capability of generating heat via uncoupled respiration. Here, Park et al. identify LETMD1 as a mitochondrial matrix protein enriched in brown adipose tissue (BAT) and reveal a crucial ro ...

Nature Portfolio2023

An Integrated Systems Genetics and Omics Toolkit to Probe Gene Function

Stephan Morgenthaler, Kristina Schoonjans, Johan Auwerx, Maroun Bou Sleiman, Hongbo Zhang, Daria Rukina, Karim Laurent Gariani, Xu Wang, Tao Lin, Peiling Luan, Hao Li, Vincenzo Sorrentino, Qingyao Huang, Naveed Ziari

2018

Sex- and age-dependent genetics of longevity in a heterogeneous mouse population

Johan Auwerx, Maroun Bou Sleiman, Giacomo Vincenzo Giorgio Von Alvensleben, Hao Li, Wen Gao

American Association for the Advancement of Science2022

INHIBITING SARM1 IS MORE EFFICACIOUS THAN NICOTINAMIDE RIBOSIDE SUPPLEMENTATION FOR THE TREATMENT OF A MOUSE MODEL WITH NAFLD/NASH

Johan Auwerx, Richardus Houtkooper, Krisztian Homicsko, Maroun Bou Sleiman, Xiaoxu Li, Sandra Rodriguez Lopez, Jia Liu, Keno Strotjohann

Lippincott Williams & Wilkins2023