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Elena Goun

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Related publications (21)

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Cell-specific image-guided transcriptomics identifies complex injuries caused by ischemic acute kidney injury in mice

Elena Goun, Pavlo Khodakivskyi

The kidney's inherent complexity has made identifying cell-specific pathways challenging, particularly when temporally associating them with the dynamic pathophysiology of acute kidney injury (AKI). Here, we combine renal cell-specific luciferase reporter ...

Springer2019

Mitochondrial copper depletion suppresses triple-negative breast cancer in mice

Elena Goun, Arkadiy Bazhin

Depletion of mitochondrial copper, which shifts metabolism from respiration to glycolysis and reduces energy production, is known to be effective against cancer types that depend on oxidative phosphorylation. However, existing copper chelators are too toxi ...

NATURE RESEARCH2021

Prediction of Occult Lymph Node Metastasis in Head and Neck Cancer with CD31 Vessel Quantification

Elena Goun

Objective The management of occult lymph node metastasis (LNM) in head and neck squamous cell carcinoma has been a matter of controversy for decades. The vascular density within the tumor microenvironment, as an indicator of ongoing angiogenesis, could con ...

SAGE PUBLICATIONS LTD2019

Real-Time Imaging and Quantification of Peptide Uptake in Vitro and in Vivo

Elena Goun, Tamara Maric, Aleksey Yevtodiyenko, Hacer Karatas, Pier Luca D'Alessandro

Peptides constitute an important class of drugs for the treatment of multiple metabolic, ontological, and neurodegenerative diseases, and several hundred novel therapeutic peptides are currently in the preclinical and clinical stages of development. Howeve ...

AMER CHEMICAL SOC2019

A fatty-acid based probe for near-infrared fluorescence guided surgery of glioblastoma

Elena Goun, Pavlo Khodakivskyi

High-grade gliomas (HGG) are the most common and most aggressive primary tumors of the brain. Despite recent advances in neuro-oncology survival of these tumors remains around 12-15 months. The first-line of treatment is surgical resection. However, due to ...

Spie-Int Soc Optical Engineering2024

A bioluminescent-based probe for in vivo non-invasive monitoring of nicotinamide riboside uptake reveals a link between metastasis and NAD plus metabolism

Ekaterina Solodnikova, Elena Goun, Arkadiy Bazhin, Pavlo Khodakivskyi, Tamara Maric, Aleksey Yevtodiyenko, Georgy Mikhaylov

Nicotinamide riboside (NR) is a form of vitamin B3 and is one of the most studied compounds for the restoration of cellular NAD+ levels demonstrating clinical potential in many metabolic and age-related disorders. Despite its wide commercial availability a ...

ELSEVIER ADVANCED TECHNOLOGY2023

Precursor molecule for the synthesis of d-luciferin

Elena Goun, Aurélien Godinat

The present invention relates to precursor molecules for the synthesis of D-luciferin, or blocked D-luciferin and derivatives thereof, which are functionalized in different positions. Further, the use of functionalized precursor molecules for the synthesis ...

2015

A bioluminescent probe for longitudinal monitoring of mitochondrial membrane potential

Elena Goun, Riccardo Sinisi, Arkadiy Bazhin, Tamara Maric, Ghyslain Martial Alain Budin

Mitochondrial membrane potential (Delta Psi(m)) is a universal selective indicator of mitochondrial function and is known to play a central role in many human pathologies, such as diabetes mellitus, cancer and Alzheimer's and Parkinson's diseases. Here, we ...

NATURE RESEARCH2020

Bioluminescent-based imaging and quantification of glucose uptake in vivo

Elena Goun, Riccardo Sinisi, Arkadiy Bazhin, Pavlo Khodakivskyi, Tamara Maric, Aleksey Yevtodiyenko, Georgy Mikhaylov

Glucose is a major source of energy for most living organisms, and its aberrant uptake is linked to many pathological conditions. However, our understanding of disease-associated glucose flux is limited owing to the lack of robust tools. To date, positron- ...

NATURE PUBLISHING GROUP2019

In Vivo Molecular Bioluminescence Imaging: New Tools and Applications

Elena Goun, Hacer Karatas

in vivo bioluminescence imaging (BLi) is an optical molecular imaging technique used to visualize molecular and cellular processes in health and diseases and to follow the fate of cells with high sensitivity using luciferase-based gene reporters. The high ...

Elsevier2017

A System for In Vivo Imaging of Hepatic Free Fatty Acid Uptake

Elena Goun, Grigory Karateev

Alterations in hepatic free fatty acid (FFA) uptake and metabolism contribute to the development of prevalent liver disorders such as hepatosteatosis. However, detecting dynamic changes in FFA uptake by the liver in live model organisms has proven difficul ...

Elsevier2017

Noninvasive imaging and quantification of bile salt hydrolase activity: From bacteria to humans

Christian Lynn Lauber, Elena Goun, Arkadiy Bazhin, Pavlo Khodakivskyi, Aleksey Yevtodiyenko

The microbiome-produced enzyme bile salt hydrolase (BSH) plays a central role in human health, but its function remains unclear due to the lack of suitable methods for measuring its activity. Here, we have developed a novel optical tool based on ultrasensi ...

AMER ASSOC ADVANCEMENT SCIENCE2021

Bioluminescence imaging of small biomolecules

Elena Goun, Aurélien Godinat, Riccardo Sinisi, Grigory Karateev, Ghyslain Martial Alain Budin, Aleksandra Konovalova, Jens Tomas Frigell

The invention relates to a technique to detect small molecules using Bioluminescence imaging (BLI) to image and quantify non-invasively, in vitro and in vivo,intracellular metabolite fluxes and which can be applied to azido-modified compounds, such as azid ...

2014

Bioluminescent compositions and uses thereof

Manuel Simon Drefahl, Elena Goun, Pavlo Khodakivskyi, Aleksey Yevtodiyenko, Hacer Karatas

Compositions and methods for non-invasively monitoring the intracellular processing of a biomolecule are provided. The compositions have a novel thio-luciferin moiety which can be conjugated to the biomolecule directly or via a linker such as disulfide bon ...

2021

Portable bioluminescent platform for in vivo monitoring of biological processes in non-transgenic animals

Elena Goun, Aurélien Godinat, Arkadiy Bazhin, Pavlo Khodakivskyi, Tamara Maric, Aleksey Yevtodiyenko, Ghyslain Martial Alain Budin

Bioluminescent imaging (BLI) is one of the most powerful and widely used preclinical imaging modalities. However, the current technology relies on the use of transgenic luciferase-expressing cells and animals and therefore can only be applied to a limited ...

Nature Research2021

Azacyanine dyes and use thereof

Elena Goun, Riccardo Sinisi, Alma Rosa Morales Morales

The application provides fluorescent dyes, which are cyanine dyes that incorporate additional aza moieties in the indolenium heterocycles and/or in the methine chains connecting them. Symmetrical and unsymmetrical chemically reactive azacyanine dyes are de ...

2019

A Universal Assay for Aminopeptidase Activity and Its Application for Dipeptidyl Peptidase-4 Drug Discovery

James William Collins, Gerardo Turcatti, Elena Goun, Marc Chambon, Arkadiy Bazhin, Jonathan Patrice Vesin, Julien Bortoli Chapalay

Aminopeptidases, such as dipeptidyl peptidase 4 (DPP-4, CD26), are potent therapeutic targets for pharmacological interventions because they play key roles in many important pathological pathways. To analyze amino-peptidase activity in vitro (including hig ...

AMER CHEMICAL SOC2019

Measurement of Long-Chain Fatty Acid Uptake into Adipocytes

Elena Goun, Grigory Karateev

The ability of white and brown adipose tissue to efficiently take up long-chain fatty acids is key to their physiological functions in energy storage and thermogenesis, respectively. Several approaches have been taken to determine uptake rates by cultured ...

Elsevier Academic Press Inc2014

Azacyanine dyes and use thereof

Elena Goun, Riccardo Sinisi, Alma Rosa Morales Morales

2019

Portable bioluminescence systems and methods for in vivo monitoring of molecular and metabolic events in animals

Elena Goun, Aurélien Godinat, Aleksey Yevtodiyenko

A system for monitoring biological processes in vivo is provided. The system comprises an implantable luciferase biosensor comprising luciferase in a biocompatible matrix and a caged luciferin probe. The caged luciferin probe can be administered to a livin ...

2018