Publication

Bioluminescent compositions and uses thereof

Elena Goun, Pavlo Khodakivskyi, Aleksey Yevtodiyenko, Hacer Karatas, Manuel Simon Drefahl
2021
Patents

Abstract

Compositions and methods for non-invasively monitoring the intracellular processing of a biomolecule are provided. The compositions have a novel thio-luciferin moiety which can be conjugated to the biomolecule directly or via a linker such as disulfide bond wherein the luminescent (such as thio-luciferin) or pro-luminescent (such as thio-cyanobenzothiazoles) moiety is released upon reduction of the disulfide bond upon cytosolic internalization.

Official source

https://infoscience.epfl.ch/entities/publication/80df1ae2-dec4-435f-a00a-f274d2eff3d2

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