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Publication

Bioluminescent compositions and uses thereof

Elena Goun, Pavlo Khodakivskyi, Aleksey Yevtodiyenko, Hacer Karatas, Manuel Simon Drefahl
2021
Patents

Abstract

Compositions and methods for non-invasively monitoring the intracellular processing of a biomolecule are provided. The compositions have a novel thio-luciferin moiety which can be conjugated to the biomolecule directly or via a linker such as disulfide bond wherein the luminescent (such as thio-luciferin) or pro-luminescent (such as thio-cyanobenzothiazoles) moiety is released upon reduction of the disulfide bond upon cytosolic internalization.

Official source

https://infoscience.epfl.ch/entities/publication/80df1ae2-dec4-435f-a00a-f274d2eff3d2

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Elena Goun, Pavlo Khodakivskyi, Aleksey Yevtodiyenko, Hacer Karatas, Manuel Simon Drefahl
2021
Patents

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/80df1ae2-dec4-435f-a00a-f274d2eff3d2

About this result

Related concepts (12)

Biomolecule

A biomolecule or biological molecule is a loosely used term for molecules present in organisms that are essential to one or more typically biological processes, such as cell division, morphogenesis, or development. Biomolecules include large macromolecules (or polyelectrolytes) such as proteins, carbohydrates, lipids, and nucleic acids, as well as small molecules such as primary metabolites, secondary metabolites and natural products. A more general name for this class of material is biological materials.

Particulate organic matter

Particulate organic matter (POM) is a fraction of total organic matter operationally defined as that which does not pass through a filter pore size that typically ranges in size from 0.053 millimeters (53 μm) to 2 millimeters. Particulate organic carbon (POC) is a closely related term often used interchangeably with POM. POC refers specifically to the mass of carbon in the particulate organic material, while POM refers to the total mass of the particulate organic matter.

Biological pump

The biological pump (or ocean carbon biological pump or marine biological carbon pump) is the ocean's biologically driven sequestration of carbon from the atmosphere and land runoff to the ocean interior and seafloor sediments. In other words, it is a biologically mediated process which results in the sequestering of carbon in the deep ocean away from the atmosphere and the land. The biological pump is the biological component of the "marine carbon pump" which contains both a physical and biological component.