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Niran Maharjan

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Niran Maharjan

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Differential role of C-terminal truncations on alpha-synuclein pathology and Lewy body formation

The process of Lewy body formation, rather than simply α-synuclein fibrillization, is one of the major drivers of neurodegeneration

Seeding the aggregation of TDP-43 requires post-fibrillization proteolytic cleavage