Jacques Fellay

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Related publications (191)

Analysis of Stop-Gain and Frameshift Variants in Human Innate Immunity Genes

Amalio Telenti, Jacques Fellay, Istvan Bartha, Paul Jack Mc Laren, Ioannis Xenarios

Loss-of-function variants in innate immunity genes are associated with Mendelian disorders in the form of primary immunodeficiencies. Recent resequencing projects report that stop-gains and frameshifts are collectively prevalent in humans and could be resp ...

Public Library Science2014

GuavaH: a compendium of host genomic data in HIV biology and disease

Amalio Telenti, Jacques Fellay, Istvan Bartha, Paul Jack Mc Laren

Background: There is an ever-increasing volume of data on host genes that are modulated during HIV infection, influence disease susceptibility or carry genetic variants that impact HIV infection. We created GuavaH (Genomic Utility for Association and Viral ...

BioMed Central2014

Influence of HLA-C Expression Level on HIV Control

Jacques Fellay, Paul Jack Mc Laren

A variant upstream of human leukocyte antigen C (HLA-C) shows the most significant genome-wide effect on HIV control in European Americans and is also associated with the level of HLA-C expression. We characterized the differential cell surface expression ...

American Association for the Advancement of Science2013

Contribution of Genetic Background, Traditional Risk Factors, and HIV-Related Factors to Coronary Artery Disease Events in HIV-Positive Persons

Amalio Telenti, Jacques Fellay, Xuan Li

Background. Persons infected with human immunodeficiency virus (HIV) have increased rates of coronary artery disease (CAD). The relative contribution of genetic background, HIV-related factors, antiretroviral medications, and traditional risk factors to CA ...

Oxford University Press2013

Association Study of Common Genetic Variants and HIV-1 Acquisition in 6,300 Infected Cases and 7,200 Controls

Amalio Telenti, Jacques Fellay, Paul Jack Mc Laren

Multiple genome-wide association studies (GWAS) have been performed in HIV-1 infected individuals, identifying common genetic influences on viral control and disease course. Similarly, common genetic correlates of acquisition of HIV-1 after exposure have b ...

Public Library Science2013

A genome-to-genome analysis of associations between human genetic variation, HIV-1 sequence diversity, and viral control

Amalio Telenti, Jacques Fellay, Istvan Bartha, Paul Jack Mc Laren

HIV-1 sequence diversity is affected by selection pressures arising from host genomic factors. Using paired human and viral data from 1071 individuals, we ran >3000 genome-wide scans, testing for associations between host DNA polymorphisms, HIV-1 sequence ...

Elife Sciences Publications Ltd2013

European genetic diversity and susceptibility to pathogens

Amalio Telenti, Jacques Fellay, Paul Jack Mc Laren

Infectious diseases, both in their endemic and epidemic forms, have shaped the human genome. Ecology has also contributed to geographically constrained pressures on human populations. There are now multiple examples of population-specific genetic variants ...

2013

A genome-wide association study of resistance to HIV infection in highly exposed uninfected individuals with hemophilia A

Amalio Telenti, Jacques Fellay, Paul Jack Mc Laren

Human genetic variation contributes to differences in susceptibility to HIV-1 infection. To search for novel host resistance factors, we performed a genome-wide association study (GWAS) in hemophilia patients highly exposed to potentially contaminated fact ...

Oxford University Press2013

Privacy-Preserving Computation of Disease Risk by Using Genomic, Clinical, and Environmental Data

Jean-Pierre Hubaux, Jacques Fellay, Erman Ayday, Paul Jack Mc Laren, Jean Louis Raisaro

According to many scientists and clinicians, genomics is the "next big thing" in the field of medicine. On one hand, decreasing costs in genome sequencing has been paving the way to better preventive and personalized medicine. On the other hand, genomic da ...

2013

Genetic interplay between HLA-C and MIR148A in HIV control and Crohn disease

Jacques Fellay, Paul Jack Mc Laren

Variation in the 3' untranslated region (3'UTR) of the HLA-C locus determines binding of the microRNA Hsa-miR-148a, resulting in lower cell surface expression of alleles that bind miR-148a relative to those alleles that escape its binding. The HLA-C 3'UTR ...

National Academy of Sciences2013

Impact of Phenotype Definition on Genome-Wide Association Signals: Empirical Evaluation in Human Immunodeficiency Virus Type 1 Infection

Amalio Telenti, Jacques Fellay

Oxford University Press2011

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