Publication

A genome-to-genome analysis of associations between human genetic variation, HIV-1 sequence diversity, and viral control

Jacques Fellay, Istvan Bartha, Paul Jack Mc Laren
2013
Journal Articles

Abstract

HIV-1 sequence diversity is affected by selection pressures arising from host genomic factors. Using paired human and viral data from 1071 individuals, we ran >3000 genome-wide scans, testing for associations between host DNA polymorphisms, HIV-1 sequence variation and plasma viral load (VL), while considering human and viral population structure. We observed significant human SNP associations to a total of 48 HIV-1 amino acid variants (p

Official source

https://infoscience.epfl.ch/entities/publication/98e28b12-ac2f-469c-8787-74f49fb9c730

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A genome-to-genome analysis of associations between human genetic variation, HIV-1 sequence diversity, and viral control

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