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Tom Hilbert

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Related publications (65)

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Morphological assessment of cartilage and osteoarthritis in clinical practice and research: Intermediate-weighted fat-suppressed sequences and beyond

Tom Hilbert

Magnetic resonance imaging (MRI) is widely regarded as the primary modality for the morphological assessment of cartilage and all other joint tissues involved in osteoarthritis. 2D fast spin echo fat-suppressed intermediate-weighted (FSE FS IW) sequences w ...

SPRINGER2023

Normal volumetric and T1 relaxation time values at 1.5 T in segmented pediatric brain MRI using a MP2RAGE acquisition

Jean-Philippe Thiran, Tobias Kober, Bénédicte Marie Maréchal, Tom Hilbert, Gian Franco Piredda

Objectives This study introduced a tailored MP2RAGE-based brain acquisition for a comprehensive assessment of the normal maturing brain. Methods Seventy normal patients (35 girls and 35 boys) from 1 to 16 years of age were recruited within a prospective mo ...

SPRINGER2021

Clinical feasibility and validation of the accelerated T2 mapping sequence GRAPPATINI in brain imaging

Tom Hilbert

Rationale and objectives: To prospectively evaluate feasibility and robustness of an accelerated T2 mapping sequence (GRAPPATINI) in brain imaging and to assess its synthetic T2-weighted images (sT2w) in comparison with a standard T2-weighted sequence (T2 ...

CELL PRESS2023

Prospective head motion correction using FID-guided on-demand image navigators

Rolf Gruetter, Reto Meuli, Tobias Kober, Gunnar Krüger, Tom Hilbert, Bénédicte Marie Maréchal, Guillaume Bonnier, Maryna Volodimirivna Waszak, Pavel Falkovskiy

PURPOSE: We suggest a motion correction concept that employs free-induction-decay (FID) navigator signals to continuously monitor motion and to guide the acquisition of image navigators for prospective motion correction following motion detection. METHODS: ...

Wiley-Blackwell2017

Clinical implementation of accelerated T-2 mapping: Quantitative magnetic resonance imaging as a biomarker for annular tear and lumbar disc herniation

Tobias Kober, Tom Hilbert

Objectives This study evaluates GRAPPATINI, an accelerated T-2 mapping sequence combining undersampling and model-based reconstruction to facilitate the clinical implementation of T-2 mapping of the lumbar intervertebral disc. Methods Fifty-eight individua ...

SPRINGER2021

An in vivo study of the orientation-dependent and independent components of transverse relaxation rates in white matter

Tobias Kober, José Pedro Rebelo Ferreira Marques, Tom Hilbert, Diana Khabipova

Diffusion-weighted imaging (DWI) provides information that allows the estimation of white-matter (WM) fibre orientation and distribution, but it does not provide information about myelin density, fibre concentration or fibre size within each voxel. On the ...

Wiley-Blackwell2016

T2 mapping for the characterization of prostate lesions

Tom Hilbert

Purpose Purpose of this study is to evaluate the diagnostic accuracy of quantitative T2/ADC values in differentiating between PCa and lesions showing non-specific inflammatory infiltrates and atrophy, features of chronic prostatitis, as the most common his ...

SPRINGER2022

A Fetal Brain magnetic resonance Acquisition Numerical phantom (FaBiAN)

Tobias Kober, Tom Hilbert, Thomas Yu

Accurate characterization of in utero human brain maturation is critical as it involves complex and interconnected structural and functional processes that may influence health later in life. Magnetic resonance imaging is a powerful tool to investigate equ ...

Nature Portfolio2022

Differentiation between benign and malignant vertebral compression fractures using qualitative and quantitative analysis of a single fast spin echo T2-weighted Dixon sequence

Tom Hilbert

Objectives To determine and compare the qualitative and quantitative diagnostic performance of a single sagittal fast spin echo (FSE) T2-weighted Dixon sequence in differentiating benign and malignant vertebral compression fractures (VCF), using multiple r ...

SPRINGER2021

Q-Dixon and GRAPPATINI T2 Mapping Parameters: A Whole Spinal Assessment of the Relationship Between Osteoporosis and Intervertebral Disc Degeneration

Tobias Kober, Tom Hilbert

Background The relationship between osteoporosis and intervertebral disc (IVD) degeneration remains controversial. Novel quantitative Dixon (Q-Dixon) and GRAPPATINI T2 mapping techniques have shown potential for evaluating the biochemical components of the ...

WILEY2022

Feasibility of accelerated T2 mapping for the preoperative assessment of endometrial carcinoma

Tobias Kober, Tom Hilbert

ObjectiveThe application value of T2 mapping in evaluating endometrial carcinoma (EMC) features remains unclear. The aim of the study was to determine the quantitative T2 values in EMC using a novel accelerated T2 mapping, and evaluate them for detection, ...

FRONTIERS MEDIA SA2023

Fast and high-resolution myelin water imaging: Accelerating multi-echo GRASE with CAIPIRINHA

Jean-Philippe Thiran, Reto Meuli, Tobias Kober, Alessandro Daducci, Tom Hilbert, Erick Jorge Canales Rodriguez, Marco Pizzolato, Gian Franco Piredda

Purpose Although several MRI methods have been explored to achievein vivomyelin quantification, imaging the whole brain in clinically acceptable times and sufficiently high resolution remains challenging. To address this problem, this work investigates the ...

Wiley2021

Brain morphometry in older adults with and without dementia using extremely rapid structural scans

Tobias Kober, Tom Hilbert

T1-weighted structural MRI is widely used to measure brain morphometry (e.g., cortical thickness and subcortical volumes). Accelerated scans as fast as one minute or less are now available but it is unclear if they are adequate for quantitative morphometry ...

ACADEMIC PRESS INC ELSEVIER SCIENCE2023

Value of MRI-T2 Mapping to Differentiate Clinically Significant Prostate Cancer

Tom Hilbert

Standardized reporting of multiparametric prostate MRI (mpMRI) is widespread and follows international standards (Pi-RADS). However, quantitative measurements from mpMRI are not widely comparable. Although T2 mapping sequences can provide repeatable quanti ...

SPRINGER2024

NovelT2Mapping for Evaluating Cervical Cancer Features by Providing QuantitativeT2Maps and Synthetic Morphologic Images: A Preliminary Study

Tobias Kober, Tom Hilbert

Background The application value of T(2)mapping in evaluating cervical cancer (CC) features remains unclear. Purpose To investigate the role of T(2)values in evaluating CC classification, grade, and lymphovascular space invasion (LVSI) in comparison to app ...

WILEY2020

SPARCQ: A new approach for fat fraction mapping using asymmetries in the phase-cycled balanced SSFP signal profile

Tobias Kober, Tom Hilbert, Katarzyna Pierzchala

Purpose: To develop SPARCQ (Signal Profile Asymmetries for Rapid Compartment Quantification), a novel approach to quantify fat fraction (FF) using asymmetries in the phase-cycled balanced SSFP (bSSFP) profile. ...

WILEY2023

Precision brain morphometry using cluster scanning

Tobias Kober, Tom Hilbert

Measurement error limits the statistical power to detect group differences and longitudinal change in structural MRI morphometric measures (e.g., hippocampal volume, prefrontal cortical thickness). Recent advances in scan acceleration enable extremely fast ...

2024

Comparison of non-parametric T2 relaxometry methods for myelin water quantification

Jean-Philippe Thiran, Tobias Kober, Alessandro Daducci, Tom Hilbert, Erick Jorge Canales Rodriguez, Nicolas Kunz, Marco Pizzolato, Gian Franco Piredda, Thomas Yu

Multi-component T2 relaxometry allows probing tissue microstructure by assessing compartment-specific T2 relaxation times and water fractions, including the myelin water fraction. Non-negative least squares (NNLS) with zero-order Tikhonov regularization is ...

2021

Tract-wise microstructural analysis informs on current and future disability in early multiple sclerosis

Jean-Philippe Thiran, Tobias Kober, Bénédicte Marie Maréchal, Tom Hilbert, Veronica Lily Ravano

Objectives Microstructural characterization of patients with multiple sclerosis (MS) has been shown to correlate better with disability compared to conventional radiological biomarkers. Quantitative MRI provides effective means to characterize micro ...

Springer Heidelberg2023

To evaluate repaired rotator cuff morphologically and quantitatively in one GRAPPATINI MRI examination

Tobias Kober, Tom Hilbert

Background: GRAPPATINI is capable of originating synthetic T2 images (T2(synth)) and T2 maps in one magnetic resonance imaging (MRI) scan. Purpose: To evaluate GRAPPATINI's performance in providing simultaneous morphological assessment of repaired rotator ...

SAGE PUBLICATIONS LTD2025