Michael Reimann

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Related publications (29)

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Assemblies, synapse clustering and network topology interact with plasticity to explain structure-function relationships of the cortical connectome

Eilif Benjamin Muller, Michael Reimann, Marwan Muhammad Ahmed Abdellah, James Gonzalo King, András Ecker, Pramod Shivaji Kumbhar, Giuseppe Chindemi, Daniela Egas Santander, James Bryden Isbister, Ioannis Magkanaris, Sirio Bolaños Puchet, Jorge Blanco Alonso

Synaptic plasticity underlies the brain’s ability to learn and adapt. While experiments in brain slices have revealed mechanisms and protocols for the induction of plasticity between pairs of neurons, how these synaptic changes are coordinated in biologica ...

2024

A connectome manipulation framework for the systematic and reproducible study of structure–function relationships through simulations

Michael Reimann, Matthias Wolf, Omar Awile, James Bryden Isbister, Christoph Pokorny, Mustafa Kerem Kurban

Synaptic connectivity at the neuronal level is characterized by highly non-random features. Hypotheses about their role can be developed by correlating structural metrics to functional features. But to prove causation, manipulations of connectivity would h ...

2024

An algorithm to predict the connectome of neural microcircuits

Henry Markram, Eilif Benjamin Muller, Srikanth Ramaswamy, Michael Reimann, James Gonzalo King

Experimentally mapping synaptic connections, in terms of the numbers and locations of their synapses and estimating connection probabilities, is still not a tractable task, even for small volumes of tissue. In fact, the six layers of the neocortex contain ...

Frontiers Research Foundation2015

Cortical reliability amid noise and chaos

Henry Markram, Eilif Benjamin Muller, Michael Reimann, James Gonzalo King, Max Christian Nolte

Typical responses of cortical neurons to identical sensory stimuli appear highly variable. It has thus been proposed that the cortex primarily uses a rate code. However, other studies have argued for spike-time coding under certain conditions. The potentia ...

Nature Research2019

Specific inhibition and disinhibition in the higher-order structure of a cortical connectome

Eilif Benjamin Muller, Michael Reimann, András Ecker, Daniela Egas Santander

Neurons are thought to act as parts of assemblies with strong internal excitatory connectivity. Conversely, inhibition is often reduced to blanket inhibition with no targeting specificity. We analyzed the structure of excitation and inhibition in the MICrO ...

Oxford University Press2024

Structural to functional synaptic conversion

Henry Markram, Felix Schürmann, Sean Lewis Hill, Eilif Benjamin Muller, Michael Reimann, James Gonzalo King

Computer-implemented methods, software, and systems for determining functional synapses from given structural touches between cells in a neuronal circuit are described. One computer-implemented method for determining functional synapses from predetermined ...

Technology Transfer Office EPFL2015

Generating and identifying functional subnetworks within structural networks

Henry Markram, Kathryn Hess Bellwald, Michael Reimann, Max Christian Nolte, Ran Levi

In one aspect, a method includes generating a functional subgraph of a network from a structural graph of the network. The structural graph comprises a set of vertices and structural connections between the vertices. Generating the functional subgraph incl ...

2018

Thalamic control of sensory processing and spindles in a biophysical somatosensory thalamoreticular circuit model of wakefulness and sleep

Henry Markram, Sean Lewis Hill, Rodrigo de Campos Perin, Michael Reimann, Marwan Muhammad Ahmed Abdellah, Werner Alfons Hilda Van Geit, Matthias Wolf, James Gonzalo King, Ying Shi, András Ecker, Rajnish Ranjan, Jean-Denis Georges Emile Courcol, Pramod Shivaji Kumbhar, Christian O'Reilly, Michael Emiel Gevaert, Fernando Joaquim Leite Pereira, Mustafa Anil Tuncel, Nadir Roman Guerrero, Elisabetta Iavarone, Mohameth François Sy, Benoît Jean-Albert Coste, Ioannis Magkanaris, Cyrille Pierre Henri Favreau, Genrich Ivaska, Anna-Kristin Kaufmann, Joni Henrikki Herttuainen, Grigori Chevtchenko, Samuel Claude Kerrien, Jayakrishnan Harikrishnavilas Raveendran Nair, Adrien Christian Fleury, Marine Laure Bertschy, Fabien Petitjean, Liviu Soltuzu, Alexander Désiré Ulbrich, Polina Litvak, Vignayanandam Ravindernath Muddapu, Patrycja Lurie

2023

Simulating Temporal Interference Stimulation

Henry Markram, Felix Schürmann, Michael Reimann, Joseph Tharayil

SPRINGER2023