Maurizio Molinari

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Related publications (52)

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Unconventional roles of nonlipidated LC3 in ERAD tuning and coronavirus infection

Maurizio Molinari

Secretory and membrane proteins attain their native structure in the endoplasmic reticulum (ER). Folding-defective polypeptides are selected for degradation by processes collectively defined as ER-associated degradation (ERAD). Enhanced ERAD activity may i ...

Landes Bioscience2012

Translocon component Sec62 acts in endoplasmic reticulum turnover during stress recovery

Maurizio Molinari

The endoplasmic reticulum (ER) is a site of protein biogenesis in eukaryotic cells. Perturbing ER homeostasis activates stress programs collectively called the unfolded protein response (UPR). The UPR enhances production of ER-resident chaperones and enzym ...

Nature Publishing Group2016

ER-phagy: Eating the Factory

Maurizio Molinari

Liang et al. (2020) reports on a genome-wide screen that reveals new aspects of starvation-induced degradation of the endoplasmic reticulum. ...

2020

A novel allosteric GCase modulator prevents Tau accumulation in GBA1WT and GBA1L444P/L444P cellular models

Maurizio Molinari

A slow decline in the autophagy-lysosomal pathway is a hallmark of the normal aging brain. Yet, an acceleration of this cellular function may propel neurodegenerative events. In fact, mutations in genes associated with the autophagy-lysosomal pathway can l ...

Springer Science and Business Media LLC2025

RETRACTED: Role of the SEL1L:LC3-I Complex as an ERAD Tuning Receptor in the Mammalian ER

Maurizio Molinari

Several regulators of endoplasmic reticulum (ER)associated degradation (ERAD) have a shorter half-life compared to conventional ER chaperones. At steady state, they are selectively removed from the ER by poorly defined events collectively referred to as ER ...

2012

Control of nuclear envelope dynamics during acute ER stress by LINC complexes disassembly and selective, asymmetric autophagy of the outer nuclear membrane

Maurizio Molinari

The endoplasmic reticulum (ER) extends to the outer (ONM) and the inner (INM) nuclear membrane forming the nuclear envelope (NE) that delimits the nucleoplasm containing the cell genome. Unfolded protein responses (UPRs) and reticulophagy responses increas ...

Taylor & Francis Inc2024

Malectin Participates in a Backup Glycoprotein Quality Control Pathway in the Mammalian ER

Maurizio Molinari

Malectin is a conserved, endoplasmic reticulum (ER)-resident lectin that recognizes high mannose oligosaccharides displaying terminal glucose residues. Here we show that Malectin is an ER stress-induced protein that selectively associates with glycopolypep ...

Public Library of Science2011

RETRACTED: Autoadaptive ER-Associated Degradation Defines a Preemptive Unfolded Protein Response Pathway

Maurizio Molinari

Folding-defective proteins must be cleared efficiently from the endoplasmic reticulum (ER) to prevent perturbation of the folding environment and to maintain cellular proteostasis. Misfolded proteins engage dislocation machineries (dislocons) built around ...

Cell Press2013

A selective ER‐phagy exerts procollagen quality control via a Calnexin‐FAM134B complex

Maurizio Molinari

Autophagy is a cytosolic quality control process that recognizessubstrates through receptor-mediated mechanisms. Procollagens,the most abundant gene products in Metazoa, are synthesized inthe endoplasmic reticulum (ER), and a fraction that fails to attaint ...

2018

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Françoise Gisou van der Goot Grunberg, Li Jin, Andreas Kern, Maurizio Molinari, Jun Ren, Wei Chen, Jian Zhang, Yi Sun, Ke Liu, Yang Sun, Wei Liu, Peng Wang, Fan Zhang, Jian Wang, Li Zhang, Giuseppe Russo, Hong Zhang, Liang Xu, Jun Li, Jian Yang, Chong Liu, Ke Li

Taylor & Francis Inc2016

Role of SEC62 in ER maintenance: A link with ER stress tolerance in SEC62-overexpressing tumors?

Maurizio Molinari

Amplification of the candidate oncogene TLOC1/SEC62 in tumors correlates with reduced patient survival. The recently reported role of SEC62 as an autophagy receptor that controls endoplasmic reticulum (ER) size and function might open new scenarios for und ...

Taylor & Francis Inc2017

Deep learning approach for quantification of organelles and misfolded polypeptide delivery within degradative compartments

Maurizio Molinari

Endolysosomal compartments maintain cellular fitness by clearing dysfunctional organelles and proteins from cells. Modulation of their activity offers therapeutic opportunities. Quantification of cargo delivery to and/or accumulation within endolysosomes i ...

2020