Publications by Ghérici Hassaïne

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Pentameric ligand-gated ion channels (LGICs) play an important role in fast synaptic signal transduction. Binding of agonists to the beta-sheet-structured extracellular domain opens an ion channel in the transmembrane alpha-helical region of the LGIC. How ...

The function of membrane proteins is best understood if their structure in the lipid membrane is known. Here, we determined the structure of the mouse serotonin 5-HT3 receptor inserted in lipid bilayers to a resolution of 12 Å without stabilizing antibodie ...

Scaffold-based protein libraries are designed to be both diverse and rich in functional/folded proteins. However, introducing an extended diversity while preserving stability of the initial scaffold remains a challenge. Here we developed an original approa ...

Cellular signaling is classically investigated by measuring optical or electrical properties of single or populations of living cells. Here we show that ligand binding to cell surface receptors and subsequent activation of signaling cascades can be monitor ...

Ghérici Hassaïne

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Thermal Unfolding of a Mammalian Pentameric Ligand-gated Ion Channel Proceeds at Consecutive, Distinct Steps

The Structure of the Mouse Serotonin 5-HT3 Receptor in Lipid Vesicles

Design of an artificial phage-display library based on a new scaffold improved for average stability of the randomized proteins

Downscaling the Analysis of Complex Transmembrane Signaling Cascades to Closed Attoliter Volumes

A Zeptoliter Volume Meter for Analysis of Single Protein Molecules