Publications by Xile Hu | EPFL Graph Search

Chat with Graph Search

Ask any question about EPFL courses, lectures, exercises, research, news, etc. or try the example questions below.

DISCLAIMER: The Graph Chatbot is not programmed to provide explicit or categorical answers to your questions. Rather, it transforms your questions into API requests that are distributed across the various IT services officially administered by EPFL. Its purpose is solely to collect and recommend relevant references to content that you can explore to help you answer your questions.

Transmidation is an attractive method for amide synthesis. However, transamidation of secondary amides is challenging. Here, we describe a reductive transamidation method that employs readily available nitro(hetero)arenes as the nitrogen sources, zinc or m ...

The first examples of Cu-catalyzed gamma-selective allylic alkenylation using organozinc reagents are reported. (E)-Alkenylzinc iodides were prepared by Fe-catalyzed reductive coupling of terminal arylalkynes with alkyl iodides. In the presence of a copper ...

A nickel pincer complex is found to catalyze alkyl–alkyl Kumada coupling reactions of 1,3- and 1,4-substituted cyclohexyl halides and tetrahydropyrans with an excellent diastereoselectivity. The mechanistic investigation of the coupling reactions provides ...

Cross coupling of non-activated alkyl halides is a potentially transformative methodology in organic synthesis. Herein we review the recent development of nickel-catalyzed coupling of non-activated alkyl halides. The current understanding of the mechanism ...

The construction of fluorinated architectures has been a topic of interest to medicinal chemists due to their unique ability to improve the pharmacokinetic properties of bioactive compounds. However, the stereoselective synthesis of fluoro-organic compound ...

Artificial metalloenzymes (ArMs) enable the integration of abiotic cofactors within a native protein scaffold, allowing for non-natural catalytic activities. Previous ArMs, however, have primarily relied on single cofactor systems, limiting them to only on ...

Tetra-n-butylammonium (TBA) (eta(6)-biphenyl)diphenyfferrate was formed unexpectedly in the reaction of (TBA)(2)[Fe4S4Cl4] with an excess of phenyllithium. This complex belongs to a novel type of organoferrate. ...

A mononuclear iron bis(carbonyl) pyridonate complex (1), which exhibits several common structural features with the active site of the iron−sulfur cluster-free [Fe]- hydrogenase, was synthesized and characterized. Spectroscopic data of 1 suggests a 2+ oxid ...

Visible-light photoredox chlorosulfonation of alkenes and alkynes is achieved using a Cu photocatalyst. The reactions occur under mild conditions, have broad scope, and have high functional group tolerance. ...

The present invention relates to 6-diazo-5-oxo-L-norleucine prodrugs having reduced toxicity and increased tumor specificity and to their therapeutic use for treating cancer. ...

A recent study revealed the structure of the Ni-containing active site of lactate racemase. The Ni is coordinated by a SCS pincer ligand derived from a nicotinic acid mononucleotide. ...

Xile Hu

Chat with Graph Search

Nickel-Catalyzed Reductive Transamidation of Secondary Amides with Nitroarenes

gamma-Selective Allylation of (E)-Alkenylzinc Iodides Prepared by Reductive Coupling of Arylacetylenes with Alkyl Iodides

Homogeneous Reactions Limit the Efficiency of Gold Electrodes in CO2 Electroreduction

Nickel-catalyzed diastereoselective alkyl-alkyl Kumada coupling

Ni-catalyzed cross coupling of non-activated alkyl halides: a mechanistic perspective

Nickel-Catalyzed Enantio- and Diastereoselective Synthesis of Fluorine-Containing Vicinal Stereogenic Centers

Artificial Metalloenzymes with Two Catalytic Cofactors for Tandem Abiotic Transformations

A Monometallic Iron(I) Organoferrate

An Iron Carbonyl Pyridonate Complex Related to the Active Site of the [Fe]-Hydrogenase (Hmd)

Biomimetic chemistry of [Fe]-hydrogenase-from synthetic models to modified enzymes

Cu-Catalyzed Photoredox Chlorosulfonation of Alkenes and Alkynes

6-diazo-5-oxo-l-norleucine prodrugs

A Novel Nickel Pincer Complex in the Active Site of Lactate Racemase