Publication

Nickel-catalyzed diastereoselective alkyl-alkyl Kumada coupling

Xile Hu, Thomas Clément Di Franco, Pablo Marcelo Perez Garcia
2012
Journal Articles

Abstract

A nickel pincer complex is found to catalyze alkyl–alkyl Kumada coupling reactions of 1,3- and 1,4-substituted cyclohexyl halides and tetrahydropyrans with an excellent diastereoselectivity. The mechanistic investigation of the coupling reactions provides evidence that the activation of alkyl halides is reversible.

Official source

https://infoscience.epfl.ch/entities/publication/2f61ee1e-88e1-4832-985c-8fd32f2652ab

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Nickel-catalyzed diastereoselective alkyl-alkyl Kumada coupling

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