Publications by Davide Demurtas

Related publications (30)

Rationally designed Human Cytomegalovirus gB nanoparticle vaccine with improved immunogenicity

Author summary Human cytomegalovirus (HCMV) infection is the foremost viral cause of congenital birth defects. Attempts to vaccinate against HCMV brought moderate, though not sufficient, reduction in infection. Moreover, phase II clinical trial with gB for ...

2020

A Cationic Micelle Complex Improves CD8+T Cell Responses in Vaccination Against Unmodified Protein Antigen

Jeffrey Alan Hubbell, Melody Swartz, Davide Demurtas, Vasiliki Panagiotou

Nanoscale carrier platforms promote immune responses to vaccination by facilitating delivery of vaccine components to immunologically relevant sites. The technique is particularly valuable for subunit vaccination, in which coadministration of immunostimula ...

Amer Chemical Soc2016

Santosomes as natural and efficient carriers for the improvement of phycocyanin reepithelising ability in vitro and in vivo

Davide Demurtas

New biocarriers, named santosomes, were formulated using Santolina insularis essential oil and hydrogenated phosphatidylcholine. They were modified by adding propylene glycol, a hydrophylic penetration enhancer, and loaded with phycocyanin, a protein found ...

Elsevier Science Bv2016

RAFT homo- and copolymerization of N-acryloyl-morpholine, piperidine, and azocane and their self-assembled structures

Jeffrey Alan Hubbell, Davide Demurtas, Yun Suk Jo

We present new polymeric amphiphiles derived from N-acryloyl derivatives of the cyclic secondary amines: morpholine, piperidine, and azocane polymerized by reversible addition -fragmentation transfer (RAFT) polymerization. Both homopolymerization and block ...

American Chemical Society2008

Flagellar microtubule doublet assembly in vitro reveals a regulatory role of tubulin C-terminal tails

Davide Demurtas, Paul Guichard, Virginie Hamel

Microtubule doublets (MTDs), consisting of an incomplete B-microtubule at the surface of a complete A-microtubule, provide a structural scaffold mediating intraflagellar transport and ciliary beating. Despite the fundamental role of MTDs, the molecular mec ...

American Association for the Advancement of Science2019

A Novel Method for the Encapsulation of Biomolecules into Polymersomes via Direct Hydration

Jeffrey Alan Hubbell, Davide Demurtas, Andrija Finka

One of the major engineering challenges for the implementation of block copolymer vesicles, or polymersomes, as therapeutic drug carriers is obtaining high encapsulation efficiencies for biomolecules. Here we present it novel method for encapsulation of pr ...

2009

Structural modifications of ionic liquid surfactants for improving the water dispersibility of carbon nanotubes: an experimental and theoretical study

Davide Demurtas

The 1-hexadecyl-3-vinylimidazolium bromide (hvimBr), a water-soluble long-chain imidazolium ionic liquid (IL) with surfactant properties, showed the ability to produce stable homogeneous aqueous dispersions of pristine Single-Walled Carbon Nanotubes (SWNTs ...

2011

Direct visualization of dispersed lipid bicontinuous cubic phases by cryo-electron tomography

Cécile Hébert, Paul Guichard, Raffaele Mezzenga, Davide Demurtas

Bulk and dispersed cubic liquid crystalline phases (cubosomes), present in the body and in living cell membranes, are believed to play an essential role in biological phenomena. Moreover, their biocompatibility is attractive for nutrient or drug delivery s ...

Nature Publishing Group2015

Extracellular matrix binding mixed micelles for drug delivery applications

Jeffrey Alan Hubbell, Jutta Christine Wandrey, Davide Demurtas

Received 5 January 2009 Accepted 22 March 2009 Available online 27 March 2009 Keywords: Mixed micelles Drug delivery Block copolymers Sirolimus Extracellular matrix We present the formation of collagen-binding mixed micelles and their potential suitability ...

2009

Micelles for delivery of nitric oxide

Jeffrey Alan Hubbell, Nikolaos Stergiopoulos, Davide Demurtas, Simone Cavadini, Yun Suk Jo

We designed block copolymer pro-amphiphiles and amphiphiles for providing very long-term release of nitric oxide (NO). A block copolymer of N-acryloylmorpholine (AM, as a hydrophile) and N-acryloyl-2,5-dimethylpiperazine (AZd, as a hydrophilic precursor) w ...

2009

Cryogenic electron tomography to determine thermodynamic quantities for nanoparticle dispersions

Francesco Stellacci, Quy Ong Khac, Paulo Henrique Jacob Silva, Davide Demurtas, Xufeng Xu, Francesca Olgiati, Anna Murello, Ting Mao

Here we present a method to extract thermodynamic quantities for nanoparticle dispersions in solvents. The method is based on the study of tomograms obtained from cryogenic electron tomography (cryoET). The approach is demonstrated for gold nanoparticles ( ...

Royal Society of Chemistry2022

Cooperative kinking at distant sites in mechanically stressed DNA

Julien Dorier, Davide Demurtas, Guillaume Witz

In cells, DNA is routinely subjected to significant levels of bending and twisting. In some cases, such as under physiological levels of supercoiling, DNA can be so highly strained, that it transitions into non-canonical structural conformations that are c ...

Oxford University Press2011

Crystalline Oligo(ethylene sulfide) Domains Define Highly Stable Supramolecular Block Copolymer Assemblies

Jeffrey Alan Hubbell, Davide Demurtas, Edward Allen Phelps

With proper control over copolymer design and solvation conditions, self-assembled materials display impressive morphological variety that encompasses nanoscale colloids as well as bulk three-dimensional architectures. Here we take advantage of both hydrop ...

Amer Chemical Soc2015

Novel features of centriole polarity and cartwheel stacking revealed by cryo-tomography

Pierre Gönczy, Paul Guichard, Davide Demurtas, Sergey Nazarov, Georgios Hatzopoulos, Alexandra Bezler, Veronika Nemcíková Villímová

Centrioles are polarized microtubule-based organelles that seed the formation of cilia, and which assemble from a cartwheel containing stacked ring oligomers ofSAS-6 proteins. A cryo-tomography map of centrioles from the termite flagellateTrichonymphaspp. ...

2020

Primary human and rat beta cells release the intracellular autoantigens GAD65, IA-2 and proinsulin in exosomes together with cytokine-induced enhancers of immunity

Jeffrey Alan Hubbell, Melody Swartz, Michele De Palma, Davide Demurtas, Romain Hamelin, Sachiko Hirosue, Chiara Cianciaruso, Edward Allen Phelps, Steinunn Baekkeskov Hanahan

The target autoantigens in several organ-specific autoimmune diseases, including type 1 diabetes (T1D), are intracellular membrane proteins, whose initial encounter with the immune system is poorly understood. Here we propose a new model for how these prot ...

American Diabetes Association2017

PEG-b-PPS diblock copolymer aggregates for hydrophobic drug solubilization and release: Cyclosporin A as an example

Jeffrey Alan Hubbell, Davide Demurtas

Micelles formed from amphiphilic block copolymers have been explored in recent years as carriers for hydrophobic drugs. In an aqueous environment, the hydrophobic blocks form the core of the micelle, which can host lipophilic drugs, while the hydrophilic b ...

2008

Molecular screening of cancer-derived exosomes by surface plasmon resonance spectroscopy

Horst Arthur Vogel, Niels Erik Lion, Michel Prudent, Davide Demurtas, Romain Wyss, Luigino Grasso

We report on a generic method to detect and iden- tify the molecular profile of exosomes either derived from cultured cell lines or isolated from biofluids. Exosomes are nanovesicles shed by cells into their microenvironment and carry the molecular identit ...

Springer Heidelberg2015

Molecular and Dimensional Profiling of Highly Purified Extracellular Vesicles by Fluorescence Fluctuation Spectroscopy

Horst Arthur Vogel, Davide Demurtas, Romain Wyss, Luigino Grasso, Camille Wolf, Hans Wolfgang Grosse

Cells secrete extracellular vesicles (EVs) into their microenvironment that act as mediators of intercellulard communication under physiological conditions and in this context also actively participate in spreading various diseases. Large efforts are curre ...

Amer Chemical Soc2014

Faceted phospholipid vesicles tailored for the delivery of Santolina insularis essential oil to the skin

Davide Demurtas

The aim of this work was to formulate Santolina insularis essential oil-loaded nanocarriers, namely Penetration Enhancer containing Vesicles (PEVs), evaluate the physico-chemical features and stability, and gain insights into their ability to deliver the o ...

Elsevier Science Bv2015

Low-Temperature Preparation of Tailored Carbon Nanostructures in Water

Anna Fontcuberta i Morral, Holger Frauenrath, Vincent Laporte, Davide Demurtas, Raffaele Mezzenga, Bernt Ketterer, Tobias Hoheisel, Martin Fritzsche

The development of low-temperature carbonization procedures promises to provide novel nanostructured carbon materials that are of high current interest in materials science and technology. Here, we report a "wet-chemical" carbonization method that utilizes ...

American Chemical Society2012