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Sean Lewis Hill

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Related publications (41)

Page 1 of 3

NineML: the network interchange for neuroscience modeling language

Eilif Benjamin Muller, Sean Lewis Hill

The growing number of large-scale neuronal network models has created a need for standards and guidelines to ease model sharing and facilitate the replication of results across different simulators. To foster community efforts towards such standards, the I ...

2011

BigNeuron: a resource to benchmark and predict performance of algorithms for automated tracing of neurons in light microscopy datasets

Pascal Fua, Sean Lewis Hill, Jiancheng Yang, Amos Sironi, Jian Yang

BigNeuron is an open community bench-testing platform with the goal of setting open standards for accurate and fast automatic neuron tracing. We gathered a diverse set of image volumes across several species that is representative of the data obtained in m ...

Nature Publishing Group2023

The Neuron Phenotype Ontology: A FAIR Approach to Proposing and Classifying Neuronal Types

Sean Lewis Hill, Mohameth François Sy

The challenge of defining and cataloging the building blocks of the brain requires a standardized approach to naming neurons and organizing knowledge about their properties. The US Brain Initiative Cell Census Network, Human Cell Atlas, Blue Brain Project, ...

HUMANA PRESS INC2022

Effective Stimuli for Constructing Reliable Neuron Models

Henry Markram, Felix Schürmann, Sean Lewis Hill, Idan Segev

The rich dynamical nature of neurons poses major conceptual and technical challenges for unraveling their nonlinear membrane properties. Traditionally, various current waveforms have been injected at the soma to probe neuron dynamics, but the rationale for ...

2011

A Framework for Collaborative Curation of Neuroscientific Literature

Sean Lewis Hill, Christian O'Reilly, Elisabetta Iavarone

Large models of complex neuronal circuits require specifying numerous parameters, with values that often need to be extracted from the literature, a tedious and error-prone process. To help establishing shareable curated corpora of annotations, we have dev ...

Frontiers Research Foundation2017

Blue Brain Nexus: An open, secure, scalable system for knowledge graph management and data-driven science

Silvia Rosario Jimenez Tejeda, Michaël Fernand Paul Dupont, Bogdan Roman, Ian Lavriushev, Didac Montero Mendez, Wojciech Adam Wajerowicz, Kenneth William Pirman, Julien Antonin Machon, Jonathan Raël Lurie, Dhanesh Neela Mana, Natalia Stafeeva, Carolina Johanna Elisabeth Lindqvist, Henry Markram, Sean Lewis Hill, Alejandra Garcia Rojas Martinez, Huanxiang Lu, Mohameth François Sy, Anna-Kristin Kaufmann, Samuel Claude Kerrien, Alexander Désiré Ulbrich, Henry Genet, Pierre-Alexandre Fonta

Modern data-driven science often consists of iterative cycles of data discovery, acquisition, preparation, analysis, model building and validation leading to knowledge discovery as well as dissemination at scale. The unique challenges of building and simul ...

2023

Modeling the effects of midazolam on cortical and thalamic neurons

Sean Lewis Hill

Controversy exists regarding the site where anesthetics act in the brain to produce sedation and unconsciousness. Actions in the cerebral cortex and thalamus are likely, although the relative importance of each site is unclear. We used in computo modeling ...

2009

Towards a supervised classification of neocortical interneuron morphologies

Sean Lewis Hill

BackgroundThe challenge of classifying cortical interneurons is yet to be solved. Data-driven classification into established morphological types may provide insight and practical value.ResultsWe trained models using 217 high-quality morphologies of rat so ...

2018

Comments and General Discussion on “The Anatomical Problem Posed by Brain Complexity and Size: A Potential Solution”

Sean Lewis Hill, Idan Segev

This article gathers together different opinions on the current status and future directions of the study of the brain, taking as a working document the article “The anatomical problem posed by brain complexity and size: a potential solution” http://journa ...

Frontiers Research Foundation2016

Modeling the Gabaergic Action of Etomidate on the Thalamocortical System

Sean Lewis Hill

BACKGROUND: We have used a computational model of the thalamocortical system to investigate the effects of a GABAergic anesthetic (etomidate) on cerebral cortical and thalamic neuronal function. We examined the effects of phasic an tonic inhibition, as wel ...

2009

The Resource Identification Initiative: A cultural shift in publishing

Sean Lewis Hill

A central tenet in support of research reproducibility is the ability to uniquely identify research resources, i.e., reagents, tools, and materials that are used to perform experiments. However, current reporting practices for research resources are insuff ...

2015

New insights into the classification and nomenclature of cortical GABAergic interneurons

Henry Markram, Sean Lewis Hill

A systematic classification and accepted nomenclature of neuron types is much needed but is currently lacking. This article describes a possible taxononnical solution for classifying GABAergic interneurons of the cerebral cortex based on a novel, web-based ...

Nature Publishing Group2013

A Component-Based Extension Framework for Large-Scale Parallel Simulations in NEURON

Henry Markram, Felix Schürmann, Sean Lewis Hill

As neuronal simulations approach larger scales with increasing levels of detail, the neurosimulator software represents only a part of a chain of tools ranging from setup, simulation, interaction with virtual environments to analysis and visualizations. Pr ...

2009

The neocortical microcircuit collaboration portal: a resource for rat somatosensory cortex

Henry Markram, Felix Schürmann, Eilif Benjamin Muller, Sean Lewis Hill, Idan Segev, Srikanth Ramaswamy, Michael Reimann, Daniel Keller, Werner Alfons Hilda Van Geit, Marwan Muhammad Ahmed Abdellah, James Gonzalo King, Lida Kanari, Julian Charles Shillcock, Ying Shi, Jean-Denis Georges Emile Courcol, Rajnish Ranjan, Juan Bautista Hernando Vieites, Stefan Eilemann, Michael Emiel Gevaert, Giuseppe Chindemi, Nicolas Antille, Jeffrey Christopher Muller, Ahmet Bilgili

We have established a multi-constraint, data-driven process to digitally reconstruct, and simulate prototypical neocortical microcircuitry, using sparse experimental data. We applied this process to reconstruct the microcircuitry of the somatosensory corte ...

Frontiers Research Foundation2015

Technology-Enabled Collaborative Care for Concurrent Diabetes and Distress Management During the COVID-19 Pandemic: Protocol for a Mixed Methods Feasibility Study

Sean Lewis Hill

Background: The COVID-19 pandemic disrupted the delivery of diabetes care and worsened mental health among many patients with type 2 diabetes (T2D). This disruption puts patients with T2D at risk for poor diabetes outcomes, especially those who experience ...

JMIR PUBLICATIONS, INC2023

Reconstruction and Simulation of Neocortical Microcircuitry

Anastasia Ailamaki, Henry Markram, Felix Schürmann, Eilif Benjamin Muller, Sean Lewis Hill, Idan Segev, Srikanth Ramaswamy, Michael Reimann, Daniel Keller, Thomas Heinis, Werner Alfons Hilda Van Geit, Rodrigo de Campos Perin, Marwan Muhammad Ahmed Abdellah, James Gonzalo King, Lida Kanari, Farhan Tauheed, Julian Charles Shillcock, Pramod Shivaji Kumbhar, Gilad Silberberg, Ying Shi, Vincent Delattre, Jean-Denis Georges Emile Courcol, Rajnish Ranjan, Juan Bautista Hernando Vieites, Stefan Eilemann, Michael Emiel Gevaert, Giuseppe Chindemi, Jean-Vincent Le Bé, Julie Meystre, Taylor Howard Newton, Max Christian Nolte, Nicolas Antille, Georges Khazen, Sébastien Lasserre, Jean Pierre Ghobril, Jeffrey Christopher Muller, Aleksandr Ovcharenko, Shruti Muralidhar, Ahmet Bilgili, Daniel Nachbaur

We present a first-draft digital reconstruction of the microcircuitry of somatosensory cortex of juvenile rat. The reconstruction uses cellular and synaptic organizing principles to algorithmically reconstruct detailed anatomy and physiology from sparse ex ...

Elsevier2015

Experimentally-constrained biophysical models of tonic and burst firing modes in thalamocortical neurons

Henry Markram, Sean Lewis Hill, Werner Alfons Hilda Van Geit, Ying Shi, Christian O'Reilly, Christian Andreas Rössert, Elisabetta Iavarone, Bas-Jan Zandt, Jane Yi

Somatosensory thalamocortical (TC) neurons from the ventrobasal (VB) thalamus are central components in the flow of sensory information between the periphery and the cerebral cortex, and participate in the dynamic regulation of thalamocortical states inclu ...

2019

A Biophysically Detailed Model of Neocortical Local Field Potentials Predicts the Critical Role of Active Membrane Currents

Henry Markram, Sean Lewis Hill, Michael Reimann, Rodrigo de Campos Perin

Brain activity generates extracellular voltage fluctuations recorded as local field potentials (LFPs). It is known that the relevant microvariables, the ionic currents across membranes, jointly generate the macrovariables, the extracellular voltage, but ne ...

Elsevier2013

Sleep improves the variability of motor performance

Sean Lewis Hill

Sleep after learning often enhances task performance, but the underlying mechanisms remain unclear. Using a well-characterized rotation learning paradigm implemented both behaviorally and in computer simulations, we compared two main hypotheses: the first, ...

2008

Large-scale extraction of brain connectivity from the neuroscientific literature

Jean-Cédric Chappelier, Sean Lewis Hill, Renaud Luc Richardet

In neuroscience, as in many other scientific domains, the primary form of knowledge dissemination is through published articles. One challenge for modern neuroinformatics is finding methods to make the knowledge from the tremendous backlog of publications ...

Oxford University Press2015