Home

Person

Jörg Hülsken

About
Privacy
Disclaimer

Graph Chatbot

Related publications (44)

Polycomb Complex PRC1 Preserves Intestinal Stem Cell Identity by Sustaining Wnt/beta-Catenin Transcriptional Activity

Polycomb repressive complexes (PRCs) are among the most important gatekeepers of establishing and maintaining cell identity in metazoans. PRC1, which plays a dominant role in this context, executes its functions via multiple subcomplexes, which all contrib ...

Cell Press2016

Outside-in integrin signalling regulates haematopoietic stem cell function via Periostin-Itgav axis

Jörg Hülsken, Albert Santamaria Martinez

Integrins play an important role in haematopoietic stem cell (HSC) maintenance in the bone marrow niche. Here, we demonstrate that Periostin (Postn) via interaction with Integrin-alpha v (Itgav) regulates HSC proliferation. Systemic deletion of Postn resul ...

Nature Publishing Group2016

Successful Immunotherapy of Cancer Stem Cells Requires Memory and the Adaptive Immune System of the Host

Jörg Hülsken, Nancy Thompson, Nicolas Pierre Desbaillets, Pierre Vincent Dessen, Patrick Schmidt

Nature Publishing Group2015

HOXA5 Counteracts Stem Cell Traits by Inhibiting Wnt Signaling in Colorectal Cancer

Caroline Dafflon, Jörg Hülsken, Paloma Ordonez Moran

Hierarchical organization of tissues relies on stem cells, which either self-renew or produce committed progenitors predestined for lineage differentiation. Here we identify HOXA5 as an important repressor of intestinal stem cell fate in vivo and identify ...

Elsevier2015

SPROUTY2 is a β-catenin and FOXO3a target gene indicative of poor prognosis in colon cancer

Jörg Hülsken, Anja Irmisch, Paloma Ordonez Moran

SPROUTY2 (SPRY2) is an intracellular regulator of receptor tyrosine kinase signaling involved in cell growth, differentiation and tumorigenesis. Here, we show that SPRY2 is a target gene of the Wnt/beta-catenin pathway that is abnormally activated in more ...

Nature Publishing Group2014

Periostin Regulates Murine Adult Hematopoiesis By Affecting Hematopoietic Stem Cells Directly As Well Through Bone Formation

Jörg Hülsken, Albert Santamaria Martinez

Elsevier Science Inc2014

Putting cancer stem cells in context

Jörg Hülsken, Ilaria Malanchi

Elsevier Sci Ltd2013

Interactions Between Breast Cancer Stem Cells and their Niche Govern Metastatic Colonization of the Lung

Jörg Hülsken, Ilaria Malanchi

Elsevier Sci Ltd2012

Interactions between cancer stem cells and their niche govern metastatic colonization

Jörg Hülsken, Ilaria Malanchi, Albert Santamaria Martinez, Hans-Anton Lehr

Metastatic growth in distant organs is the major cause of cancer mortality. The development of metastasis is a multistage process with several rate-limiting steps. Although dissemination of tumour cells seems to be an early and frequent event, the successf ...

2012

Neural stem cells are increased after loss of β-catenin, but neural progenitors undergo cell death

Jörg Hülsken

Neurons and glia in the central nervous system originate from neural stem and progenitor cells that reside in the ventricular zones. Here we examine the role of beta-catenin in neural stem cell (NSC) regulation in mouse embryos lacking beta-catenin specifi ...

Wiley-Blackwell2011

β-catenin represses expression of the tumour suppressor 15-prostaglandin dehydrogenase in the normal intestinal epithelium and colorectal tumour cells

Jörg Hülsken, Paloma Ordonez Moran

BACKGROUND: Cyclooxygenase-2 (COX-2) overexpression in colorectal cancer increases levels of its pro-tumorigenic product prostaglandin E2 (PGE(2)). The recently identified colorectal tumour suppressor 15-prostaglandin dehydrogenase (15-PGDH) catalyses pros ...

BMJ Publishing Group2011

Targeting extracellular matrix molecules for the treatment of cancer

Jörg Hülsken, Ilaria Malanchi

The present invention relates to an agent able to block a cancer supportive function of a fasciclin protein family member and to pharmaceutical compositions containing the same. ...

2011

SOX2 is an oncogene activated by recurrent 3q26.3 amplifications in human lung squamous cell carcinomas

Jörg Hülsken

Squamous cell carcinoma (SCC) of the lung is a frequent and aggressive cancer type. Gene amplifications, a known activating mechanism of oncogenes, target the 3q26-qter region as one of the most frequently gained/amplified genomic sites in SCC of various t ...

Public Library of Science2010

Genetic dissection of differential signaling threshold requirements for the Wnt/beta-catenin pathway in vivo

Jörg Hülsken

Contributions of null and hypomorphic alleles of Apc in mice produce both developmental and pathophysiological phenotypes. To ascribe the resulting genotype-to-phenotype relationship unambiguously to the Wnt/beta-catenin pathway, we challenged the allele c ...

Public Library of Science2010

Canonical Wnt signalling plays essential roles

Jörg Hülsken

Wiley2009

Inducibility of Drug-metabolizing Enzymes by Xenobiotics in Mice with Liver-specific Knockout of Ctnnb1

Jörg Hülsken, Massimiliano Schwarz

Basal as well as xenobiotic-induced expression of the main enzymes from phase I and phase II of drug metabolism is confined to the perivenous areas of the mammalian liver lobule. Whereas signal transduction pathways that govern xenobiotic-induced expressio ...

2009

Tissue-specific stem cells: friend or foe?

Jörg Hülsken

2009

Reciprocal requirements for EDA/EDAR/NF-kappaB and Wnt/beta- catenin signaling pathways in hair follicle induction

Jörg Hülsken, Yi Zhang

Wnt/beta-catenin and NF-kappaB signaling mechanisms provide central controls in development and disease, but how these pathways intersect is unclear. Using hair follicle induction as a model system, we show that patterning of dermal Wnt/beta-catenin signal ...

Cell Press - Elsevier2009

Cancer stem cells: never Wnt away from the niche

Jörg Hülsken, Ilaria Malanchi

PURPOSE OF REVIEW: The last years of cancer research have established the concept of cancer stem cells (CSCs) as a subpopulation of cells within a tumor entirely responsible for tumorigenesis. This has aroused expectations that targeting cancer stem cells ...

2009

T-cell development occurs in the combined absence of the canonical Wnt signal-transducers beta- and gamma-catenin

Jörg Hülsken, Ilaria Malanchi, Stéphane Duboux, Fabien Kuttler

2008

Page 2 of 3