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Felix Schürmann

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Related publications (82)

Page 4 of 5

Models of neocortical layer 5b pyramidal cells capturing a wide range of dendritic and perisomatic active properties

Henry Markram, Felix Schürmann, Sean Lewis Hill, Idan Segev

The thick-tufted layer 5b pyramidal cell extends its dendritic tree to all six layers of the mammalian neocortex and serves as a major building block for the cortical column. L5b pyramidal cells have been the subject of extensive experimental and modeling ...

2011

EBRAINS Live Papers-Interactive Resource Sheets for Computational Studies in Neuroscience

Felix Schürmann

We present here an online platform for sharing resources underlying publications in neuroscience. It enables authors to easily upload and distribute digital resources, such as data, code, and notebooks, in a structured and systematic way. Interactivity is ...

HUMANA PRESS INC2022

The Scientific Case for Brain Simulations

Felix Schürmann

A key element of the European Union's Human Brain Project (HBP) and other large-scale brain research projects is the simulation of large-scale model networks of neurons. Here, we argue why such simulations will likely be indispensable for bridging the scal ...

CELL PRESS2019

A neuron membrane mesh representation for visualization of electrophysiological simulations

Henry Markram, Felix Schürmann, Sean Lewis Hill, Juan Bautista Hernando Vieites, Sébastien Lasserre

We present a process to automatically generate three-dimensional mesh representations of the complex, arborized cell membrane surface of cortical neurons (the principal information processing cells of the brain) from nonuniform morphological measurements. ...

Institute of Electrical and Electronics Engineers2012

Polynomial Evaluation on Superscalar Architecture, Applied to the Elementary Function e(x)

Felix Schürmann, Fabien Jonathan Delalondre, Francesco Cremonesi, Timothée Ewart

The evaluation of small degree polynomials is critical for the computation of elementary functions. It has been extensively studied and is well documented. In this article, we evaluate existing methods for polynomial evaluation on superscalar architecture. ...

2020

ARC: An Open Web-Platform for Request/Supply Matching for a Prioritized and Controlled COVID-19 Response

Pavlo Getta, Henry Markram, Felix Schürmann, Jean-Denis Georges Emile Courcol

In 2020 the world was hit by the COVID-19 pandemic putting entire governments and civil societies in crisis mode. Around the globe unprecedented shortages of equipment and qualified personnel were reported in hospitals and diagnostic laboratories. When a c ...

FRONTIERS MEDIA SA2021

Generating High Fidelity Surface Meshes of Neocortical Neurons using Skin Modifiers

Felix Schürmann, Marwan Muhammad Ahmed Abdellah, Juan Bautista Hernando Vieites, Cyrille Pierre Henri Favreau, Samuel Lieven D. Lapere

We present the results of exploring the capabilities of skinning modifiers to generate high fidelity polygonal surface meshes of neurons from their morphological skeletons that are segmented from optical microscopy slides. Our algorithm is implemented in B ...

2019

A Hierarchical Structure of Cortical Interneuron Electrical Diversity Revealed by Automated Statistical Analysis

Henry Markram, Felix Schürmann, Sean Lewis Hill, Idan Segev

Although the diversity of cortical interneuron electrical properties is well recognized, the number of distinct electrical types (e-types) is still a matter of debate. Recently, descriptions of interneuron variability were standardized by multiple laborato ...

Oxford University Press2013

BluePyOpt: Leveraging Open Source Software and Cloud Infrastructure to Optimise Model Parameters in Neuroscience

Henry Markram, Felix Schürmann, Eilif Benjamin Muller, Idan Segev, Werner Alfons Hilda Van Geit, Jean-Denis Georges Emile Courcol, Giuseppe Chindemi, Michael Emiel Gevaert

At many scales in neuroscience, appropriate mathematical models take the form of complex dynamical systems. Parametrising such models to conform to the multitude of available experimental constraints is a global nonlinear optimisation problem with a comple ...

Frontiers Research Foundation2016

Performance evaluation of the IBM POWER8 architecture to support computational neuroscientific application using morphologically detailed neurons

Felix Schürmann

A part of large-scale future supercomputing architectures will rely on a combination of IBM POWER9 and Nvidia GPU processors. In order to anticipate software design, implementation and optimization decisions and optimally prepare scientific applications ta ...

Association for Computing Machinery2015

OCTOPUS: Efficient Query Execution on Dynamic Mesh Datasets

Anastasia Ailamaki, Henry Markram, Felix Schürmann, Thomas Heinis, Farhan Tauheed

Scientists in many disciplines use spatial mesh models to study physical phenomena. Simulating natural phenomena by changing meshes over time helps to understand and predict future behavior of the phenomena. The higher the precision of the mesh models, the ...

2014

Toward Biophysical Mechanisms of Neocortical Computation after 50 Years of Barrel Cortex Research

Graham Knott, Carl Petersen, Felix Schürmann

2021

Caries Detection with Near-Infrared Transillumination Using Deep Learning

Henry Markram, Felix Schürmann, Taylor Howard Newton, Francesco Casalegno

Dental caries is the most prevalent chronic condition worldwide. Early detection can significantly improve treatment outcomes and reduce the need for invasive procedures. Recently, near-infrared transillumination (TI) imaging has been shown to be effective ...

2019

Physically-based in silico light sheet microscopy for visualizing fluorescent brain models

Henry Markram, Felix Schürmann, Marwan Muhammad Ahmed Abdellah, Stefan Eilemann, Ahmet Bilgili

We present a physically-based computational model of the light sheet fluorescence microscope (LSFM). Based on Monte Carlo ray tracing and geometric optics, our method simulates the operational aspects and image formation process of the LSFM. This simulated ...

BioMed Central2015

Evaluating automated parameter constraining procedures of neuron models by experimental and surrogate data

Henry Markram, Felix Schürmann, Sean Lewis Hill, Idan Segev

Neuron models, in particular conductance-based compartmental models, often have numerous parameters that cannot be directly determined experimentally and must be constrained by an optimization procedure. A common practice in evaluating the utility of such ...

2008

Accelerating Range Queries For Brain Simulations

Henry Markram, Anastasia Ailamaki, Felix Schürmann, Thomas Heinis, Farhan Tauheed

Neuroscientists increasingly use computational tools to build and simulate models of the brain. The amounts of data involved in these simulations are immense and the importance of their efficient management is primordial. One particular problem in analyzin ...

2012

Neuromapp: A Mini-application Framework to Improve Neural Simulators

Felix Schürmann, Judit Planas Carbonell, Fabien Jonathan Delalondre, Francesco Cremonesi, Timothée Ewart

The increasing complexity and heterogeneity of extreme scale systems makes the optimization of large scale scientific applications particularly challenging. Efficiently leveraging these complex systems requires a great deal of technical expertise and a con ...

Springer International Publishing2017

Accelerating Data Analysis in Simulation Neuroscience with Big Data Technologies

Felix Schürmann, Judit Planas Carbonell, Fabien Jonathan Delalondre

Important progress in computational sciences has been made possible recently thanks to the increasing computing power of high performance systems. Following this trend, larger scientific studies, like brain tissue simulations, will continue to grow in the ...

Springer International Publishing2018

Reconstruction and simulation of neocortical microcircuitry

Henry Markram, Felix Schürmann, Sean Lewis Hill, Eilif Benjamin Muller

Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for reconstructing and simulating neocortical microcircuitry. In one aspect, a method includes providing a model of neural tissue, the model including differ ...

2018

Special issue on quantitative neuron modeling

Wulfram Gerstner, Felix Schürmann, Renaud Jolivet

Springer Verlag2008