Publications by Ralf Mekle | EPFL Graph Search

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Recently, the spin-echo full-intensity acquired localized (SPECIAL) spectroscopy technique was proposed to unite the advantages of short TEs on the order of milliseconds (ms) with full sensitivity and applied to in vivo rat brain. In the present study, SPE ...

Short-TE MRS has been proposed recently as a method for the in vivo detection and quantification of gamma-aminobutyric acid (GABA) in the human brain at 3 T. In this study, we investigated the accuracy and reproducibility of short-TE MRS measurements of GA ...

Proton MR spectra of the brain, especially those measured at short and intermediate echo times, contain signals from mobile macromolecules (MM). A description of the main MM is provided in this consensus paper. These broad peaks of MM underlie the narrower ...

Schizophrenia pathophysiology implies both abnormal redox control and dysconnectivity of the prefrontal cortex, partly related to oligodendrocyte and myelin impairments. As oligodendrocytes are highly vulnerable to altered redox state, we investigated the ...

BACKGROUND: Oxidative stress and glutathione (GSH) metabolism dysregulation has been implicated in the pathophysiology of schizophrenia. GAG-trinucleotide repeat (TNR) polymorphisms in the glutamate-cysteine ligase catalytic gene (GCLC), the rate-limiting ...

Magnetic resonance spectroscopy is a powerful, non-invasive, quantitative imaging technique that allows for the measurement of brain metabolites that has demonstrated utility in diagnosing and characterizing a broad range of neurological diseases. Its impa ...

Magnetic resonance spectroscopy (MRS) allows measurement of neurotransmitter concentrations within a region of interest in the brain. Inter-individual variation in MRS-measured GABA levels have been related to variation in task performance in a number of r ...

Purpose: To measure the proton density (PD), the T1 and T2 relaxation time, and magnetization transfer (MT) effects in human median nerve at 3 T and to compare them with the corresponding values in muscle. ...

The double spin-echo point resolved spectroscopy sequence (PRESS) is a widely used method and standard in clinical MR spectroscopy. Existence of important J-modulations at constant echo times, depending on the temporal delays between the rf-pulses, have be ...

PURPOSE: To investigate magnetization transfer (MT) effects as a new source of contrast for imaging and tracking of peripheral foot nerves. MATERIALS AND METHODS: Two sets of 3D spoiled gradient-echo images acquired with and without a saturation pulse were ...

Eddy currents induced by switching of magnetic field gradients can lead to distortions in short echo-time spectroscopy or diffusion weighted imaging. In small bore magnets, such as human head-only systems, minimization of eddy current effects is more deman ...

To determine whether glycine can be measured at 7 T in human brain with H-1 magnetic resonance spectroscopy (MRS). ...

The purpose of this study was to evaluate a new polymer-based and magnetic resonance (MR) imaging-compatible guide wire for its application in MR-guided endovascular interventions, particularly for interventional peripheral MR angiography in swine experime ...

Objective To evaluate a transverse electromagnetic (TEM), a circularly polarized (CP) (birdcage), and a 12-channel phased array head coil at the clinical field strength of B (0) = 3T in terms of signal-to-noise ratio (SNR), signal homogeneity, and maps of ...

Introduction: Magnetic resonance imaging (MRI) is an excellent imaging modality for soft tissues. Magnetization transfer (MT) imaging is an MRI technique that is sensitive to the bound protons of macromolecules and therefore can aid in the assessment of ne ...

After the landmark studies reporting changes in the cerebral metabolic rate of glucose (CMR(Glc) ) in excess of those in oxygen (CMR(O2) ) during physiological stimulation, several studies have examined the fate of the extra carbon taken up by the brain, r ...

Ralf Mekle

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MR Spectroscopy of the Human Brain With Enhanced Signal Intensity at Ultrashort Echo Times on a Clinical Platform at 3T and 7T

Unedited in vivo detection and quantification of gamma-aminobutyric acid in the occipital cortex using short-TE MRS at 3 T

Contribution of macromolecules to brain H-1 MR spectra: Experts' consensus recommendations

Glutathione deficit impairs myelin maturation: relevance for white matter integrity in schizophrenia patients

Genetic Polymorphism Associated Prefrontal Glutathione and Its Coupling With Brain Glutamate and Peripheral Redox Status in Early Psychosis

Harmonization of multi-scanner in vivo magnetic resonance spectroscopy: ENIGMA consortium task group considerations

Relationship between physiological measures of excitability and levels of glutamate and GABA in the human motor cortex

NMR Properties of Human Median Nerve at 3 T: Proton Density, T1, T2, and Magnetization Transfer

Echo-time independent signal modulations for strongly coupled systems in triple echo localization schemes: An extension of S-PRESS editing

Magnetization transfer-based 3D visualization of foot peripheral nerves

Eddy current effects on a clinical 7T-68 cm bore scanner

In vivo measurement of glycine with short echo-time H-1 MRS in human brain at 7 T

Genetic Association with Prefrontal Glutathione Deficit: A 3T 1H MRS Study in Early Psychosis

Initial In Vivo Studies with a Polymer-based MR-compatible Guide Wire

Comparison of three commercially available radio frequency coils for human brain imaging at 3 Tesla

Magnetic resonance imaging of peripheral nerves: Differences in magnetization transfer

High-Quality MR Spectroscopy of the Human Brain with Full Signal Intensity at Echo Times Below 6 ms on a Clinical Platform at 3T and 7T

Net increase of lactate and glutamate concentration in activated human visual cortex detected with magnetic resonance spectroscopy at 7 tesla

Glutathione Deficit Affects White Matter Integrity in Prefrontal Cortex and Impairs Brain Connectivity in Schizophrenia