Home

Person

Philip Pattison

This person is no longer with EPFL

About
Privacy
Disclaimer

Graph Chatbot

Related publications (86)

Nonenzymic polycyclisation of analogues of oxidosqualene with a preformed C-ring

Philip Pattison

Some nonenzymic epoxide-initiated polyolefin cyclisations are reported. The presented molecules are partially constrained analogues of (3S)-oxidosqualene, the natural substrate to many important cyclase enzymes. These model compounds feature a preformed C- ...

2008

Photoluminescent Microporous Lanthanide Silicate AV-21 Frameworks

Philip Pattison

The hydrothermal synthesis and structural characterization of the lanthanide silicate system [Na6Ln2Si12O30x H2O] (Ln=La3+, Sm3+, Eu3+, Gd3+, and Tb3+), named AV-21, has been reported. Structural elucidation of the Sm3+ analogue (isomorphous with the Eu3+, ...

2008

Metergoline II: structure solution from powder diffraction data with preferred orientation and from microcrystal

Philip Pattison

Metergoline is a dopamine agonist and serotonin antagonist used both in human and veterinary medicine. In addition to the previously known crystalline form, a new polymorph, which crystallizes from aqueous solution, was found. Since it was initially imposs ...

2008

Multimodal Distribution of Quantum Confinement in Ripened CdSe Nanocrystals

Majed Chergui, Awos Al Salman, Philip Pattison

We present three different prepn. methods for CdSe colloidal nanoparticles that, when carried out into the Ostwald ripening regime, lead to the development of complex spectral patterns resulting from the overlap of several distinct components corresponding ...

2008

KSm(MoO4)2, an incommensurately modulated and partially disordered scheelite-like structure

Gervais Chapuis, Alla Arakcheeva, Philip Pattison

The incommensurately modulated scheelite-like KSm(MoO4)2 structure has been refined in the monoclinic superspace group I2/b(ab0)00 by the Rietveld method on the basis of synchrotron radiation powder diffraction data. The systematic broadening of satellite ...

2008

Molecular envelopes derived from protein powder diffraction Molecular envelopes derived from protein powder diffraction data

Philip Pattison, Sebastian Basso

The preparation of single crystals suitable for X-ray analysis is frequently the most difﬁcult step in structural studies of proteins.With the aid of two examples, it is shown that de novo solution of the crystallographic phase problem can be achieved at l ...

2008

The low-temperature structure of nopinone

Philip Pattison

6,6-dimethylbicyclo[3.1.1]heptan-2-one, (1R)-(+)-nopinone, is a liquid at room temperature. It solidifies below 260 K to form an orientationally disordered body-centred cubic phase (a = 7.644 Å at 255 K), which transforms to an ordered structure below 240 ...

2008

Using X-ray absorption spectra to monitor specific radiation damage to anomalously scattering atoms in macromolecular crystallography

Marc Fleurant, Philip Pattison

Radiation damage in macromolecular crystals is not suppressed even at 90 K. This is particularly true for covalent bonds involving an anomalous scatterer (such as bromine) at the `peak wavelength'. It is shown that a series of absorption spectra recorded o ...

2007

Powder diffraction studies on proteins: An overview of data collection approaches

Philip Pattison

Following the seminal work of Von Dreele, high quality powder X-ray diffraction studies on proteins are being established as a valuable complementary technique to single-crystal measurements. Several studies using a variety of experiments approaches have b ...

2007

Polymorphism in N-Salicylideneaniline Reconsidered

Gervais Chapuis, Kurt Schenk, Philip Pattison

2007

New insight into the pectolite – serandite series: a single crystal diffraction study of Na(Ca1.73Mn0.27)[HSi3O9] at 293 and 100 K

Gervais Chapuis, Alla Arakcheeva, Philip Pattison

2007

Crystal and Electronic Structures of Magnesium(II), Copper(II), and Mixed Magnesium(II)−Copper(II) Complexes of the Quinoline Half of Styrylquinoline-Type HIV-1 Integrase Inhibitors

Philip Pattison

A new target in AIDS therapy development is HIV-1 integrase (IN). It was proven that HIV-1 IN required divalent metal cations to achieve phosphodiester bond cleavage of DNA. Accordingly, all newly investigated potent IN inhibitors contain chemical fragment ...

2007

A Polymorph Lost and Found: The High-Temperature Crystal Structure of Pentacene

Philip Pattison

Wiley2007

Polarization-dependence of anomalous scattering in brominated DNA and RNA molecules, and importance of crystal orientation in single- and multiple-wavelength anomalous diffraction phasing

Marc Fleurant, Philip Pattison

In this paper the anisotropy of anomalous scattering at the Br K-absorption edge in brominated nucleotides is investigated, and it is shown that this effect can give rise to a marked directional dependence of the anomalous signal strength in X-ray diffract ...

2007

Experimental and theoretical characterization of the Zn-Zn bond in [Zn2([eta]5-C5Me5)2]

Philip Pattison

The experimental electron density obtained from a multipole refinement of the synchrotron X-ray data for the title complex, together with theoretical ab initio calculations of the electron density at the molecular geometry obtained from neutron diffraction ...

2007

Thermal decomposition of AlH3 studied by in situ synchrotron X-ray diffraction and thermal desorption spectroscopy

Philip Pattison

The thermal decomposition of alane was investigated by application of synchrotron X-ray diffraction (SR-XRD) and thermal desorption spectroscopy (TDS). Two polymorphs were studied, α- and γ-AlH3. Activation energies, anisotropic volume expansions, and phas ...

2007

Exploiting X-ray induced anisotropic lattice changes to improve intensity extraction in protein powder diffraction: Application to heavy atom detection

Marc Fleurant, Philip Pattison, Annasara Dahlström

X-ray induced anisotropic variations of cell parameters in porcine pancreatic elastase (PPE) were used in a multi-Pawley refinement in order to improve the deconvolution of overlapping peaks occurring in the high-angle region of the powder pattern. The ben ...

2007

A structural investigation of the four phases of 7-oxabicyclo[2.2.1]heptane

Philip Pattison

Powder synchrotron X-ray diffraction studies confirm that 7-oxabicyclo[2.2.1]heptane, (oxanorbornane), forms three solid phases on cooling and four on warming, as previously indicated by spectroscopic and DSC meas urements. The two highest temperature phas ...

2007

Structure of 1,4,10,19,25,41-C70(CF3)6, isomer with unique arrangement of addends

Philip Pattison

A novel isomer of C70(CF3)6 has been isolated by HPLC from a mixture prepared by trifluoromethylation of C70 with CF3COOAg. The X-ray structure revealed an unprecedented arrangement of CF3 groups forming a p3mp ribbon. This result provides additional evide ...

2006

Pressure-Induced Chemical Decomposition and Structural Changes of Boric Acid

Philip Pattison, Vladimir Dmitriev

A combined synchrotron X-ray diffraction, Raman scattering, and infrared spectroscopy study of the pressure-induced changes in H3BO3 to 10 GPa revealed a new high-pressure phase transition between 1 and 2 GPa followed by chemical decomposition into cubic H ...

2006

Page 4 of 5