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Didier Trono

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Related publications (149)

Lentiviral vectors, two decades later

Didier Trono

American Association for the Advancement of Science2016

A Large-Scale Functional Screen to Identify Epigenetic Repressors of Retrotransposon Expression

Didier Trono, Helen Mary Rowe, Gabriela Ecco

Deposition of epigenetic marks is an important layer of the transcriptional control of retrotransposons, especially during early embryogenesis. Krüppel-associated box domain zinc finger proteins (KRAB-ZFPs) are one of the largest families of transcription ...

2016

Molecular Criteria for Defining the Naive Human Pluripotent State

Didier Trono, Julien Léonard Duc, Marc Samuel Friedli, Alexandra Iouranova, Michaël Imbeault, Evaristo Jose Planet Letschert, Julien Paul André Pontis, Haoyi Wang

Recent studies have aimed to convert cultured human pluripotent cells to a naive state, but it remains unclear to what extent the resulting cells recapitulate in vivo naive pluripotency. Here we propose a set of molecular criteria for evaluating the naive ...

Cell Press2016

Methods for purging isolated organs and cells from latent human cytomegalovirus

Didier Trono, Benjamin Rauwel

The present invention relates to a method for purging ex vivo isolated organs or isolated cells from latent human cytomegalovirus (HCMV). The invention further relates to a compound for use in a method for treating HCMV infection. ...

2015

Release of human cytomegalovirus from latency by a KAP1/TRIM28 phosphorylation switch

Didier Trono, Isabelle Barde, Adamantia Kapopoulou, Benjamin Rauwel, Marco Cassano, Suk Min Jang

Human cytomegalovirus (HCMV) is a highly prevalent pathogen that induces life-long infections notably through the establishment of latency in hematopoietic stem cells (HSC). Bouts of reactivation are normally controlled by the immune system, but can be fat ...

2015

A KAP1 phosphorylation switch controls MyoD function during skeletal muscle differentiation

Didier Trono, Marco Cassano, Suk Min Jang, Evaristo Jose Planet Letschert

The transcriptional activator MyoD serves as a master controller of myogenesis. Often in partnership with Mef2 (myocyte enhancer factor 2), MyoD binds to the promoters of hundreds of muscle genes in proliferating myoblasts yet activates these targets only ...

Cold Spring Harbor Lab Press, Publications Dept2015

Dual-Regulated Lentiviral Vector for Gene Therapy of X-Linked Chronic Granulomatous Disease

Didier Trono

Nature Publishing Group2015

Dual-regulated lentiviral vector for gene therapy of x-linked chronic granulomatous disease

Didier Trono, Pierre Rossi

Mary Ann Liebert, Inc2015

Potential Of Induced Pluripotent Stem Cells For The Treatment Of Crigler-Najjar Liver Disease

Didier Trono, Marc Samuel Friedli, Sandra Eloise Kjeldsen

Elsevier Science Bv2015

As Time Goes by: KRABs Evolve to KAP Endogenous Retroelements

Didier Trono, Michaël Imbeault

Retroelements, constituting about 50% of the human genome, both contribute to its evolution and threaten its integrity and are thus silenced during development. Jacobs et al. (2014) identify sequence-specific KRAB-ZNF proteins that repress subsets of L1 an ...

Cell Press - Elsevier2014

Transposable elements and their epigenetic control mechanisms are key regulators of transcriptional networks in pluripotent stem cells

Didier Trono

Mary Ann Liebert, Inc2014

Modulation of mitophagy and use thereof

Didier Trono, Isabelle Barde

The present invention relates to an agent or composition comprising at least one of: (i) a micro-RNA targeting a mitophagy-associated gene or a variant thereof, (ii) a vector comprising a nucleic acid encoding said micro-RNA or variant thereof, (iii) an in ...

2014

Dual-Regulated Lentiviral Vector for Gene Therapy of X-Linked Chronic Granulomatous Disease

Didier Trono

Nature Publishing Group2014

Loss of transcriptional control over endogenous retroelements during reprogramming to pluripotency

Didier Trono, Priscilla Turelli, Bastien Mangeat, Helen Mary Rowe, Marc Samuel Friedli, Adamantia Kapopoulou, Gabriela Ecco, Benjamin Rauwel, Carmen Maria Unzu Ezquerro, Evaristo Jose Planet Letschert

Endogenous retroelements (EREs) account for about half of the mouse or human genome, and their potential as insertional mutagens and transcriptional perturbators is suppressed by early embryonic epigenetic silencing. Here, we asked how ERE control is maint ...

Cold Spring Harbor Lab Press, Publications Dept2014

Identification of the transcription factor ZEB1 as a central component of the adipogenic gene regulatory network

Gilles Udin, Didier Trono, Andrea Corsinotti, Bart Deplancke, Sunil Kumar Raghav, Sebastian Martin Waszak, Petra Catalina Schwalie

Adipose tissue is a key determinant of whole body metabolism and energy homeostasis. Unraveling the regulatory mechanisms underlying adipogenesis is therefore highly relevant from a biomedical perspective. Our current understanding of fat cell differentiat ...

Elife Sciences Publications Ltd2014

Dual-Regulated Lentiviral Vector for Gene Therapy of X-linked Chronic Granulomatous Disease

Didier Trono, Pierre Rossi

Mary Ann Liebert, Inc2014

Control of mitophagie by microRNAs - A key step of erythropoiesis

Didier Trono, Isabelle Barde, Sonia Verp, Andrea Corsinotti, Jiri Vanicek, Sandra Eloise Kjeldsen, Adamantia Kapopoulou, Ray Marcel Marin Florez, Benjamin Rauwel

Edp Sciences S A2014

A KRAB/KAP1-miRNA Cascade Regulates Erythropoiesis Through Stage-Specific Control of Mitophagy

Didier Trono, Isabelle Barde, Sonia Verp, Andrea Corsinotti, Jiri Vanicek, Sandra Eloise Kjeldsen, Adamantia Kapopoulou, Ray Marcel Marin Florez, Benjamin Rauwel

During hematopoiesis, lineage- and stage-specific transcription factors work in concert with chromatin modifiers to direct the differentiation of all blood cells. Here, we explored the role of KRAB-containing zinc finger proteins (KRAB-ZFPs) and their cofa ...

American Association for the Advancement of Science2013

Peripuberty stress leads to abnormal aggression, altered amygdala and orbitofrontal reactivity and increased prefrontal MAOA gene expression

Pierre Magistretti, Maria del Carmen Sandi Perez, Maria Isabel Cordero Campana, Didier Trono, Anna Claire Groner, Cristina Marquez Vega, Guillaume Poirier

Although adverse early life experiences have been found to increase lifetime risk to develop violent behaviors, the neurobiological mechanisms underlying these long-term effects remain unclear. We present a novel animal model for pathological aggression in ...

Nature Publishing Group2013

De novo DNA methylation of endogenous retroviruses is shaped by KRAB-ZFPs/KAP1 and ESET

Didier Trono, Sonia Verp, Helen Mary Rowe, Marc Samuel Friedli, Sandra Eloise Kjeldsen

Endogenous retroviruses (ERVs) undergo de novo DNA methylation during the first few days of mammalian embryogenesis, although the factors that control the targeting of this process are largely unknown. We asked whether KAP1 (KRAB-associated protein 1) is i ...

Company Of Biologists Ltd2013

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