Home

Person

Hilal Lashuel

About
Privacy
Disclaimer

Graph Chatbot

Related publications (155)

Parkinson-related parkin reduces α-Synuclein phosphorylation in a gene transfer model

α-Synuclein aggregates in Lewy bodies and plays a central role in the pathogenesis of a group of neurodegenerative disorders, known as "Synucleinopathies", including Parkinson's disease. Parkin mutations result in loss of parkin E3-ubiquitin ligase activit ...

2010

Role of post-translational modifications in modulating the structure, function and toxicity of alpha-synuclein: implications for Parkinson's disease pathogenesis and therapies

Hilal Lashuel, Abid Oueslati

A better understanding of the molecular and cellular determinants that influence the pathology of Parkinson's disease (PD) is essential for developing effective diagnostic, preventative and therapeutic strategies to treat this devastating disease. A number ...

Elsevier2010

Amyloidogenic protein-membrane interactions: mechanistic insight from model systems

Hilal Lashuel

The toxicity of amyloid-forming proteins is correlated with their interactions with cell membranes. Binding events between amyloidogenic proteins and membranes result in mutually disruptive structural perturbations, which are associated with toxicity. Memb ...

2010

Stable -Synuclein Oligomers Strongly Inhibit Chaperone Activity of the Hsp70 System by Weak Interactions with J-domain Co-chaperones

Giovanni Dietler, Mounir Driss Mensi, Hilal Lashuel, Pierre Goloubinoff

alpha-Synuclein aggregation and accumulation in Lewy bodies are implicated in progressive loss of dopaminergic neurons in Parkinson disease and related disorders. In neurons, the Hsp70s and their Hsp40-like J-domain co-chaperones are the only known compone ...

2010

A new class of isothiocyanate-based irreversible inhibitors of macrophage migration inhibitory factor

Bruno Claude Daniel Fauvet, Hilal Lashuel, Hajer Ouertatani-Sakouhi, Farah El Turk, Magdalena Zweckstetter

Macrophage migration inhibitory factor (MIF) is a homotrimeric multifunctional proinflammatory cytokine that has been implicated in the pathogenesis of several inflammatory and autoimmune diseases. Current therapeutic strategies for targeting MIF focus on ...

American Chemical Society2009

Amyloid-Beta Modifies Astrocytic Metabolic Phenotype

Pierre Magistretti, Hilal Lashuel, Igor Allaman, David Viertl

2009

Structure and function of the molecular chaperone Hsp104 from yeast

Hilal Lashuel

The molecular chaperone Hsp104 plays a central role in the clearance of aggregates after heat shock and the propagation of yeast prions. Hsp104's disaggregation activity and prion propagation have been linked to its ability to resolubilize or remodel prote ...

Wiley-Blackwell2009

The role of post-translational modification (phosphorylation) in modulating alpha-synuclein, structure, aggregation and toxicity

Hilal Lashuel

2009

Structural properties of pore-forming oligomers of alpha-synuclein

Hilal Lashuel, Min Kyu Cho, Magdalena Zweckstetter, Ajay Kumar

Soluble oligomers are potent toxins in many neurodegenerative diseases, but little is known about the structure of soluble oligomers and their structure-toxicity relationship. Here we prepared on-pathway oligomers of the 140-residue protein alpha-synuclein ...

American Chemical Society2009

The conformational flexibility of the carboxy terminal residues 105-114 is a key modulator of the catalytic activity and stability of macrophage migration inhibitory factor

Ursula Röthlisberger, Hilal Lashuel, Hajer Ouertatani-Sakouhi, Michele Cascella, Farah El Turk, Magdalena Zweckstetter

Macrophage migration inhibitory factor (MIF) is a multifunctional protein and a major mediator of innate immunity. Although X-ray crystallography revealed that MIF exists as a homotrimer, its oligomerization state in vivo and the factors governing its olig ...

American Chemical Society2008

Disruption of amyloid-derived peptide assemblies through the controlled induction of a beta-sheet to alpha-helix transformation: application of the switch concept

Richard Alan Mimna, Marie-Stéphanie Camus, Hilal Lashuel, Adrian Schmid

Reversal of amyloid formation through a controlled induced transformation from beta-sheet to sol. alpha-helix structures through the use of a switch element S could have an important consequences understanding the mechanisms of amyloid formation and cleara ...

Wiley-VCH Verlag GmbH2007

Switch-peptides as folding precursors in self-assembling peptides and amyloid fibrillogenesis

Karine Murat, Jérémy Bérard, Richard Alan Mimna, Marie-Stéphanie Camus, Hilal Lashuel, Adrian Schmid

The study of conformational transitions of peptides has obtained considerable attention recently because of their importance as a mol. key event in a variety of degenerative diseases. However, the study of peptide self-assembly into beta-sheets and amyloid ...

2007

Switch-peptides: from conformational studies to Alzheimer's disease

Jacques Dubochet, Sonia Dos Santos, Karine Murat, Jérémy Bérard, Lydiane Jeanine Saucède, Richard Alan Mimna, Marie-Stéphanie Camus, Hilal Lashuel

A review. Studies on designed peptides that exhibit high tendencies for medium-induced conformational transitions have recently attracted much attention because structural changes are considered as mol. key processes in degenerative diseases. The exptl. ac ...

2006

Are amyloid diseases caused by protein aggregates that mimic bacterial pore-forming toxins?

Hilal Lashuel

Protein fibrillization is implicated in the pathogenesis of most, if not all, age-associated neurodegenerative diseases, but the mechanism(s) by which it triggers neuronal death is unknown. Reductionist in vitro studies suggest that the amyloid protofibril ...

Cambridge University Press2006

A century-old debate on protein aggregation and neurodegeneration enters the clinic

Hilal Lashuel

The correlation between neurodegenerative disease and protein aggregation in the brain has long been recognized, but a causal relationship has not been unequivocally established, in part because a discrete pathogenic aggregate has not been identified. The ...

2006

Page 8 of 8