Rodrigo de Campos Perin

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Previous studies based on the 'Quantal Model' for synaptic transmission suggest that neurotransmitter release is mediated by a single release site at individual synaptic contacts in the neocortex. However, recent studies seem to contradict this hypothesis ...

Copyright © 2024 Meystre, Jacquemier, Burri, Zsolnai, Frank, Vieira, Shi, Perin, Keller and Markram.Nissl histology underpins our understanding of brain anatomy and architecture. Despite its importance, no high-resolution datasets are currently available i ...

Despite decades of extracellular action potential (EAP) recordings monitoring brain activity, the biophysical origin and inherent variability of these signals remains enigmatic. We performed whole-cell patch recordings of excitatory and inhibitory neurons ...

The electrochemical processes that underlie neural function manifest themselves in ceaseless spatiotemporal field fluctuations. However, extracellular fields feed back onto the electric potential across the neuronal membrane via ephaptic coupling, independ ...

The lack of a formal link between neural network structure and its emergent function has hampered our understanding of how the brain processes information. We have now come closer to describing such a link by taking the direction of synaptic transmission i ...

The structure in cortical microcircuits deviates from what would be expected in a purely random network, which has been seen as evidence of clustering. To address this issue, we sought to reproduce the nonrandom features of cortical circuits by considering ...

A consensus on the number of morphologically different types of pyramidal cells (PCs) in the neocortex has not yet been reached, despite over a century of anatomical studies, due to the lack of agreement on the subjective classifications of neuron types, w ...

The general structure of the mammalian neocortex is remarkably similar across different cortical areas. Despite certain cytoarchitectural specializations and deviations from the general blueprint, the principal organization of the neocortex is relatively u ...

The patch-clamp technique is today the most well-established method for recording electrical activity from individual neurons or their subcellular compartments. Nevertheless, achieving stable recordings, even from individual cells, remains a time-consuming ...

The organizational principles that distinguish the human brain from other species have been a long-standing enigma in neuroscience. Focusing on the uniquely evolved human cortical layers 2 and 3, we computationally reconstruct the cortical architecture for ...

Pyramidal cells (PCs) form the backbone of the layered structure of the neocortex, and plasticity of their synapses is thought to underlie learning in the brain. However, such long-term synaptic changes have been experimentally characterized between only a ...

Brain activity generates extracellular voltage fluctuations recorded as local field potentials (LFPs). It is known that the relevant microvariables, the ionic currents across membranes, jointly generate the macrovariables, the extracellular voltage, but ne ...

We present a first-draft digital reconstruction of the microcircuitry of somatosensory cortex of juvenile rat. The reconstruction uses cellular and synaptic organizing principles to algorithmically reconstruct detailed anatomy and physiology from sparse ex ...

Inhibitory pathways are an essential component in the function of the neocortical microcircuitry. Despite the relatively small fraction of inhibitory neurons in the neocortex, these neurons are strongly activated due to their high connectivity rate and the ...

Neuronal circuitry is often considered a clean slate that can be dynamically and arbitrarily molded by experience. However, when we investigated synaptic connectivity in groups of pyramidal neurons in the neocortex, we found that both connectivity and syna ...

Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for organizing trained and untrained neural networks. In one aspect, a neural network device includes a collection of node assemblies interconnected by betwe ...

Interactions among neurons can take place in a wide variety of forms. It is the goal of this thesis to investigate the properties and implications of a number of these interactions that we believe are relevant for information processing in the brain. Neuro ...

The lateral amygdala (LA) encodes fear memories by potentiating sensory inputs associated with threats and, in the process, recruits 10-30% of its neurons per fear memory engram. However, how the local network within the LA processes this information and w ...

The organization of connectivity in neuronal networks is fundamental to understanding the activity and function of neural networks and information processing in the brain. Recent studies show that the neocortex is not only organized in columns and layers b ...

Rodrigo de Campos Perin

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Estimating the Readily-Releasable Vesicle Pool Size at Synaptic Connections in the Neocortex

Cell density quantification of high resolution Nissl images of the juvenile rat brain

Cell-type- and activity-dependent extracellular correlates of intracellular spiking

Ephaptic coupling of cortical neurons

Cliques of Neurons Bound into Cavities Provide a Missing Link between Structure and Function

On the Structure of Cortical Microcircuits Inferred from Small Sample Sizes

Objective Morphological Classification of Neocortical Pyramidal Cells

Frequency-dependent disynaptic inhibition in the pyramidal network: a ubiquitous pathway in the developing rat neocortex

A computer-assisted multi-electrode patch-clamp system

Of mice and men: Dendritic architecture differentiates human from mouse neuronal networks

A calcium-based plasticity model for predicting long-term potentiation and depression in the neocortex

A Biophysically Detailed Model of Neocortical Local Field Potentials Predicts the Critical Role of Active Membrane Currents

Reconstruction and Simulation of Neocortical Microcircuitry

Brief Bursts Self-Inhibit and Correlate the Pyramidal Network

A synaptic organizing principle for cortical neuronal groups

Organizing neural networks

Emergent Dynamics in Neocortical Microcircuits

Fear learning induces synaptic potentiation between engram neurons in the rat lateral amygdala

Computing the size and number of neuronal clusters in local circuits

Innate neural assemblies for lego memory