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Wee Han Ang

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Related publications (42)

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A structure-based mechanism of cisplatin resistance mediated by glutathione transferase P1-1

Paul Joseph Dyson, Wee Han Ang, Laure Menin

Cisplatin [cis-diamminedichloroplatinum(II) (cis-DDP)] is one of the most successful anticancer agents effective against a wide range of solid tumors. However, its use is restricted by side effects and/or by intrinsic or acquired drug resistance. Here, we ...

National Academy of Sciences2019

Investigation into the formation of heteronuclear clusters of formula [ Ru6C(CO)16Ag2X 2]2- (X = Cl, Br or I)

Paul Joseph Dyson, Rosario Scopelliti, Wee Han Ang

Reaction of [Ru6C(CO)16]2− with an excess of AgX (X = Cl, Br or I) affords heteronuclear clusters of formula [{Ru6C(CO)16Ag2X}2]2− in 80% yield, which for X = I and X = ...

2007

Development of Organometallic Ruthenium-Arene Anticancer Drugs That Resist Hydrolysis

Paul Joseph Dyson, Rosario Scopelliti, Wee Han Ang, Claudine Scolaro

With a view to develop drugs that could resist hydrolysis in aq. media,organometallic arene-capped ruthenium(II) 1,3,5-triaza-7-phosphatricyclo[3.3.1.1]decane (RAPTA) complexes bearing chelating carboxylate ligands have been prepd. and studied. The new com ...

2006

Synthesis of new aminophosphine complexes and their catalytic activities in C-C coupling reactions

Rosario Scopelliti, Zhaofu Fei, Wee Han Ang

Two new aminophosphines, benzyl-N(Ph2P)(2) and 2-picolyl-N(Ph2P)(2), have been synthesized. Oxidation of the aminophosphines with either hydrogen peroxide, elemental sulfur and selenium gave the corresponding oxides, sulfides and selenides benzyl-N(Ph2P=E) ...

2008

Strategy To Tether Organometallic Ruthenium-Arene Anticancer Compounds to Recombinant Human Serum Albumin

Paul Joseph Dyson, Wee Han Ang

In order to utilize macromols. for drug targeting and delivery, a strategy to tether organometallic ruthenium-arene drugs to carrier protein mols. was developed. The approach involves the design of a drug fragment capable of conjugating to linker mols. on ...

2007

Remarkable Anticancer Activity of Triruthenium-Arene Clusters Compared to Tetraruthenium-Arene Clusters

Paul Joseph Dyson, Wee Han Ang

The in vitro activity of a series of ruthenium clusters, [(η6-C6H6)(η6-C6Me6)2Ru3(μ-H)3(μ3-O)][BF4], [(η6-C6H6)(η6-1,4-iPrC6H4Me)(η6-C6Me6)Ru3(μ-H)3(μ3-O)][BF4], [(η6-C6H6)4Ru4(μ-H)4][BF4]2, [(η6-C6H5Me)4Ru4(μ-H)4][BF4]2 and [(η6-C6H6)4Ru4(μ-H)3(μ-OH)][Cl] ...

Springer US2007

Ligand substitutions between ruthenium-cymene compounds can control protein versus DNA targeting and anticancer activity

Paul Joseph Dyson, Ursula Röthlisberger, Wee Han Ang, Alexey Nazarov, Pablo Campomanes Ramos, Catherine Marie Amélie Clavel, Michael Groessl

Ruthenium compounds have become promising alternatives to platinum drugs by displaying specific activities against different cancers and favourable toxicity and clearance properties. Nonetheless, their molecular targeting and mechanism of action are poorly ...

Nature Research2014

Palladium nanoparticles stabilized by an ionic polymer and ionic liquid: A versatile system for C-C cross-coupling reactions

Paul Joseph Dyson, Zhaofu Fei, Wee Han Ang, Dongbin Zhao, Xuemei Yang

Highly stable palladium nanoparticles 5 nm diam., protected by an imidazolium-based ionic polymer in a nitrile-functionalized ionic liq., have been prepd. and characterized by TEM. These Pd nanoparticles are excellent precatalysts for Suzuki, Heck, and Sti ...

2008

Development of nitrile-functionalized ionic liquids for C-C coupling reactions: implication of carbene and nanoparticle catalysts

Paul Joseph Dyson, Rosario Scopelliti, Zhaofu Fei, Wee Han Ang, Dongbin Zhao

A series of nitrile-functionalized imidazolium salts (many of which are liquid at room temperature) have been prepared. The reactivity of these salts with PdCl2 has been studied, resulting in salts containing a tetrachloropalladate dianion or co ...

2007

Anthracene-Tethered Ruthenium(II) Arene Complexes as Tools To Visualize the Cellular Localization of Putative Organometallic Anticancer Compounds

Paul Joseph Dyson, Rosario Scopelliti, Christian Hartinger, Wee Han Ang, Alexey Nazarov, Olivier Pierre Zava, Michael Groessl, Albert Ruggi, Frédéric Schmitt, Julie Risse

Anthracene derivatives of ruthenium(II) arene compounds with 1,3,5-triaza-7-phosphatricyclo[3.3.1.1]decane (pta) or a sugar phosphite ligand, viz., 3,5,6-bicyclophosphite1,2-O-isopropylidene-alpha-D-glucofuranoside, were prepared in order to evaluate their ...

2012

Development of organometallic ruthenium(II) anticancer (RAPTA) drugs

Wee Han Ang

A review. The systematic development of the RAPTA family of organometallic ruthenium(II) anticancer drugs contg. a monodentate 1,3,5-triaza-7-phosphatricyclo-[3.3.1.1]decane ligand and a h6-arene ligand is described. ...

2007

Application of N,N-bis(diphenylphosphino)aniline palladium(II) complexes as pre-catalysts in Heck coupling reactions

Paul Joseph Dyson, Wee Han Ang

Palladium(II) complexes with N,N-bis(diphenylphosphino)aniline ligands catalyze the Heck reaction between styrene and aryl bromides, affording stilbenes in good yield. The structures of two of the complexes used as pre-catalysts have been detd. by single-c ...

2007

A Supercooled Imidazolium Iodide Ionic Liquid as a Low-Viscosity Electrolyte for Dye-Sensitized Solar Cells

Michael Graetzel, Paul Joseph Dyson, Shaik Mohammed Zakeeruddin, Zhaofu Fei, Wee Han Ang, Dongbin Zhao

A series of allyl-functionalized imidazolium salts are reported, including 1-allyl-3-ethylimidazolium iodide and 1-allyl-3-propylimidazolium iodide, which have m.ps. close to room temp. and show typical properties of supercooled fluids if heated above thei ...

2006

Development of an Efficient Dual-Action GST-Inhibiting Anticancer Platinum(IV) Prodrug

Paul Joseph Dyson, Patrycja Nowak-Sliwinska, Wee Han Ang

The cytotoxicity of cisplatin (cDDP) is enhanced when co-administered with ethacrynic acid (EA), a glutathione S-transferase (GST) inhibito r. A Pt-lV EA conjugate containing a cDDP core and two axial ethacrynate ligands (compound 1) was shown to be an ex ...

2018

Rational design of platinum(IV) compounds to overcome glutathione-S-transferase mediated drug resistance

Paul Joseph Dyson, Wee Han Ang, Claire Samantha Allardyce

2005

In Vitro Evaluation of Rhodium and Osmium RAPTA Analogues: The Case for Organometallic Anticancer Drugs Not Based on Ruthenium

Paul Joseph Dyson, Gabor Laurenczy, Wee Han Ang, Andrew Douglas Phillips, Antoine Dorcier

Reaction of the dimer [(η5-C5Me5)RhCl(μ2-Cl)]2 with 2 or 4 equiv of the water-soluble phosphine 1,3,5-triaza-7-phosphatricyclo[3.3.1.1]decane (pta) affords [Rh(η5-C5Me< ...

2006

Revisiting Ether-Derivatized Imidazolium-Based Ionic Liquids

Paul Joseph Dyson, Rosario Scopelliti, Zhaofu Fei, Wee Han Ang, Dongbin Zhao

A series of ether-derivatized imidazolium halides have been prepd. and characterized. Contrary to literature reports, they are all cryst. solids and have m.ps. well above room temp. (50-100 °C). Single crystals of the imidazolium salts, obtained in situ by ...

2007

Thiocyanate functionalised ionic liquids: synthesis, characterisation and reactivity

Paul Joseph Dyson, Rosario Scopelliti, Zhaofu Fei, Wee Han Ang, Dongbin Zhao

The reaction of chloromethyl thiocyanate with 1-methylimidazole affords the imidazolium salt, 1-thiocyanomethyl-3-methylimidazolium chloride, [C1SCNmim]Cl (1a). Exchange of the chloride anion in 1a by [PF6] ...

2007

Complexation associated rearrangement of iminobiphosphines to diphosphinoamines

Paul Joseph Dyson, Rosario Scopelliti, Zhaofu Fei, Wee Han Ang, Dongbin Zhao

The reaction of the iminobiphosphines RN[dbnd]>PPh2-PPh2, where R = C6H4(p-CN), C6H4(m-CN), C6H4(o-C6H5), C6F5 or C6

2006

ESI-MS characterisation of protein adducts of anticancer ruthenium(II)-arene PTA (RAPTA) complexes

Paul Joseph Dyson, Wee Han Ang, Angela Casini

Electrospray ionization mass spectrometry allows a rapid characterization of the adducts formed between three novel anticancer ruthenium(II)-arene PTA compds. and horse heart cytochrome c or hen egg white lysozyme. Specific information on the nature of the ...

2007