Publication

Strategy To Tether Organometallic Ruthenium-Arene Anticancer Compounds to Recombinant Human Serum Albumin

Paul Joseph Dyson, Wee Han Ang
2007
Journal Articles

Abstract

In order to utilize macromols. for drug targeting and delivery, a strategy to tether organometallic ruthenium-arene drugs to carrier protein mols. was developed. The approach involves the design of a drug fragment capable of conjugating to linker mols. on a modified carrier protein via hydrazone bond formation. The proof-of-concept using recombinant human serum albumin is described.

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Strategy To Tether Organometallic Ruthenium-Arene Anticancer Compounds to Recombinant Human Serum Albumin

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